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Princeton research: In the early life of an embryo, a monster lurks
Date:8/22/2011

oped additional mechanisms that we don't know about. It would be interesting to know what those mechanisms are," Wieschaus said.

"From my own standpoint, the paper makes me want to check back through mutant lines that disrupt development and have never been fully described or understood, but might be affected in this process. This model gives a sense of what to look for, and that is always valuable."

Just as the experiment-based models developed by Stanford's Ferrell fueled Wingreen's work, Wingreen hopes his models can guide further study of embryo development in the laboratory. He said the next steps are to reproduce the simulations in actual embryos, and to test the limits of calcium-wave synchronization to learn if it holds up when development on one side of an embryo is slowed, or if the two halves of a split embryo would remain coordinated.

"These are all experimental steps," Wingreen said. "My group does theory and modeling, so our hope is that we've put the ball back in the experimentalists' court."


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Contact: Morgan Kelly
mgnkelly@princeton.edu
609-258-5729
Princeton University
Source:Eurekalert

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