Navigation Links
Princeton research: In the early life of an embryo, a monster lurks
Date:8/22/2011

ing something would happen if we ran these formulas in a spatially extended system."

The initial simulation tested how cell activity would spread through the embryo solely by diffusion. Oscillation indeed found its way across the cell, but disorder took root almost instantly. Cells divided at different speeds, with many left undeveloped by the end of the cycle. As the simulation went on for 200 minutes, the mayhem grew worse. A real embryo would not survive this breakdown, or would at least be left with severe developmental problems, Wingreen said.

Wingreen and McIsaac began to suspect that the calcium wave had a role in keeping the cellular peace. Although known to spark cell cycles, the full purpose of the calcium wave had previously had some shadow of mystery, Wingreen said. But once the team ruled out that cell activity could self-regulate, they knew something else brought order to the developing embryo. The calcium wave -- which spreads across the embryo rapidly following fertilization -- seemed a likely candidate.

The researchers then simulated cell division with fast and slow calcium waves. Slow waves creeping at 1 millimeter every 10 minutes opened the door for havoc. However, when sped up in the simulation to travel a millimeter in four minutes, the calcium wave synchronized cell activity, and the embryo developed normally. The simulation exposed the calcium wave as not only an initiator of embryo development but also a regulator of that activity.

If the calcium wave doubles as a regulator, then it could have other functions. Moreover, other mechanisms that seemingly serve one purpose may also have others. These possible extra duties could be behind other happenings in embryo cells that are not well understood, said Eric Wieschaus, the Squibb Professor of Molecular Biology at Princeton and a 1995 Nobel Prize winner.

"The fact that the system generally doesn't devolve into chaos might mean that embryos have devel
'/>"/>

Contact: Morgan Kelly
mgnkelly@princeton.edu
609-258-5729
Princeton University
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. Princeton scientists construct synthetic proteins that sustain life
2. Princeton researchers find that high-fructose corn syrup prompts considerably more weight gain
3. Princeton scientists find way to catalog all that goes wrong in a cancer cell
4. NCI awards $15.2 million to create Princeton Physical Sciences -- Oncology Center
5. Princeton team learns why some drugs pack such a punch
6. Princeton teams analysis of flu virus could lead to better vaccines
7. Princeton geoscientist offers new evidence that meteorite did not wipe out dinosaurs
8. Princeton researchers discover new type of laser
9. Princeton-led team finds secret ingredient for the health of tropical rainforests
10. MS research: Myelin influences how brain cells send signals
11. USC research: Cancer cells and stem cells share same origin
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/17/2015)... , March 17, 2015  MecklerMedia Corporation (OTCQX: ... exhibition for service robots ever held in ... place on May 11-13, 2015 at the Javits ... for the event include: Acorn Product Development; Axis ... Infranor; Kinova Robotics; Littler; NewBotic Corporation; Neya Systems ...
(Date:3/12/2015)... , March 12, 2015 IriTech, a ... a member of the Texas Instruments Design Network, announced ... has demonstrated its IriShield USB MK2120U device during ... facility for pension distribution. The iris ... to be marketed in India ...
(Date:3/12/2015)... , March 12, 2015 ... standardized identity and access management (IAM) solution for ... schedule. With Beta System,s new IAM package, customers ... practices gleaned from multiple IAM implementations across different ... software as well as any necessary services and ...
Breaking Biology News(10 mins):MecklerMedia's RoboUniverse New York Announces Sponsors and Exhibitors, May 11-13, 2015 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 3Beta Systems Fast Forward IAM Available Now: a Standardized IAM Package at a Fixed Price 2
... (Aug. 8, 2013) Female mice who were growth restricted in ... less active and prone to obesity as adults, said researchers from ... Nutrition Research Center (CNRC) at BCM and Texas Children,s ... International Journal of Obesity . "Given that ...
... In a world full of hungry predators, prey animals ... face a particular challenge when it comes to defending themselves. ... interesting is that they can,t run away," says John Orrock, ... run, you can,t necessarily hide, so what can you do? ...
... recovery efforts following the devastating effects of the 2011 tsunami ... within the reactor,s core. A study in the journal ... Alamos National Laboratory (LANL) shows that muon imaging may offer ... and locating the melted fuel. Muon imaging, which utilizes ...
Cached Biology News:Kids born small should get moving 2Eavesdropping plants prepare to be attacked 2Getting to the core of Fukushima 2
(Date:3/25/2015)... SHANGHAI , CAMBRIDGE, Mass. and ... -- WuXi NextCODE, which provides comprehensive capabilities for using the ... deCODE genetics on their publication of the largest studies of ... published today online in Nature Genetics ... date of sequence variation, authored by a team of deCODE ...
(Date:3/25/2015)... Fla. , March 25, 2015  Point-of-Care ... and management consulting firm, has launched the ePrescribing ... to simplify tracking of ePrescribing regulatory requirements in ... "The ePrescribing regulatory landscape continues to change rapidly, ... deliver what the industry, and ultimately patients, need," ...
(Date:3/25/2015)... (PRWEB) March 25, 2015 Having added ... the latter part of 2014, ITRA Global proudly announced ... the International Tenant Representative Alliance, based in the United ... representing tenants and occupiers of commercial real estate. , ... advisory firm in Poland that exclusively advises occupiers of ...
(Date:3/25/2015)... HAGUE, Netherlands , March 25, 2015  EndoStim ... for chronic gastro-esophageal reflux disease (GERD) in the March ... Surgery . 2015; 157(3):556-567 ], establishing the long term ... The study included 25 patients with severe GERD ... prescribed daily proton pump inhibitor (PPI) medication for an ...
Breaking Biology Technology:Landmark deCODE Studies Demonstrate the Power of Truly Big Genomics for Improving Medicine Worldwide 2Point-of-Care Partners Launches the ePrescribing State Law Capsule 2International Organization Expands its Global Reach to Warsaw, Poland 2EndoStim LES Stimulation therapy demonstrates long term safety and efficacy results in treating reflux patients 2EndoStim LES Stimulation therapy demonstrates long term safety and efficacy results in treating reflux patients 3
... got turned on its head again last week, as British ... aircraft. For the vast majority of U.S. travelers, new regulations ... have toothpaste and shampoo when they arrive at their destinations ... at airport arrivals terminals). For the sake of security, well ...
... according to schedule, the newest multimillion-dollar research institution at ... sometime after 2010. , ,But even as architects design ... leaders are busy forging its identity. , ,Marsha Seltzer, ... as interim director of WID, a $375 million multidisciplinary ...
... After months of speculation, North Prairie Productions, LLC , ... site for a biodiesel plant that will produce 45 million ... construction on the $42 million facility next spring on about ... it will relocate its Waterloo offices. , ,The site ...
Cached Biology Technology:Opportunities rise from travel chaos 2Waisman director leading early stages of the Wisconsin Institutes for Discovery 2Waisman director leading early stages of the Wisconsin Institutes for Discovery 3Evansville site chosen for biodiesel plant 2
... shaker flask clips, purpose-designed to firmly retain ... clips are equipped with a top retainer ... a bottom retainer spring, and silicon tubing ... glassware. Clips include the required mounting ...
RABBIT ANTI HUMAN ALPHA-2-ANTIPLASMIN...
... Bullseye Red Taq DNA Polymerase ... exhibits very high activity in primer extension ... contains a red dye which provides easy ... enzyme was added and allows confirmation of ...
RNA oligomers from 10 to 50 bases purified by PAGE and MS-checked. RNAs are supplied dried and fully deprotected....
Biology Products: