Navigation Links
Princeton research: In the early life of an embryo, a monster lurks
Date:8/22/2011

ing something would happen if we ran these formulas in a spatially extended system."

The initial simulation tested how cell activity would spread through the embryo solely by diffusion. Oscillation indeed found its way across the cell, but disorder took root almost instantly. Cells divided at different speeds, with many left undeveloped by the end of the cycle. As the simulation went on for 200 minutes, the mayhem grew worse. A real embryo would not survive this breakdown, or would at least be left with severe developmental problems, Wingreen said.

Wingreen and McIsaac began to suspect that the calcium wave had a role in keeping the cellular peace. Although known to spark cell cycles, the full purpose of the calcium wave had previously had some shadow of mystery, Wingreen said. But once the team ruled out that cell activity could self-regulate, they knew something else brought order to the developing embryo. The calcium wave -- which spreads across the embryo rapidly following fertilization -- seemed a likely candidate.

The researchers then simulated cell division with fast and slow calcium waves. Slow waves creeping at 1 millimeter every 10 minutes opened the door for havoc. However, when sped up in the simulation to travel a millimeter in four minutes, the calcium wave synchronized cell activity, and the embryo developed normally. The simulation exposed the calcium wave as not only an initiator of embryo development but also a regulator of that activity.

If the calcium wave doubles as a regulator, then it could have other functions. Moreover, other mechanisms that seemingly serve one purpose may also have others. These possible extra duties could be behind other happenings in embryo cells that are not well understood, said Eric Wieschaus, the Squibb Professor of Molecular Biology at Princeton and a 1995 Nobel Prize winner.

"The fact that the system generally doesn't devolve into chaos might mean that embryos have devel
'/>"/>

Contact: Morgan Kelly
mgnkelly@princeton.edu
609-258-5729
Princeton University
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. Princeton scientists construct synthetic proteins that sustain life
2. Princeton researchers find that high-fructose corn syrup prompts considerably more weight gain
3. Princeton scientists find way to catalog all that goes wrong in a cancer cell
4. NCI awards $15.2 million to create Princeton Physical Sciences -- Oncology Center
5. Princeton team learns why some drugs pack such a punch
6. Princeton teams analysis of flu virus could lead to better vaccines
7. Princeton geoscientist offers new evidence that meteorite did not wipe out dinosaurs
8. Princeton researchers discover new type of laser
9. Princeton-led team finds secret ingredient for the health of tropical rainforests
10. MS research: Myelin influences how brain cells send signals
11. USC research: Cancer cells and stem cells share same origin
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... BEACH GARDENS, Fla. , March 24, 2015 ... biometric identity management solutions, today announced that its ... premium clothing accessory retailer Goorin Bros . ... The Crossmatch biometrics-based solution secures access to the ... from the increased risk of data breaches. ...
(Date:3/23/2015)... --NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company"), ... market, announces its biometric payment technology, the Wocket® smart wallet, ... March 30 th . The new ... York markets. Gino Pereira ... new ad campaign following the recent initial shipment of Wocket ...
(Date:3/20/2015)... Markets ( http://www.researchandmarkets.com/research/vkzvcs/iris_biometrics ) has announced the addition ... report to their offering. This report analyzes ... report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... . Annual estimates and forecasts are provided for ...
Breaking Biology News(10 mins):Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5
... Satellite tracking of threatened loggerhead sea turtles has revealed ... that are providing important habitat for at least three separate ... in the journal Biological Conservation . The ... of Southwest Florida and the northern tip of the Yucatan ...
... Cleveland Clinic and Case Western Reserve University are ... Consortium (TNC), which will investigate and develop better ... spinal injuries related to sports, military service and ... by researchers who have collaborated on state-of-the-art research ...
... MANHATTAN, KAN. -- Think of it as cooking with ... new ways to create and work with carbon nanotubes ... or string. These carbon nanotubes -- made of ... perfect ingredients for improving laser detectors and rechargeable batteries, ...
Cached Biology News:Satellite tracking reveals sea turtle feeding hotspots 2Satellite tracking reveals sea turtle feeding hotspots 3Cleveland Clinic, Case Western Reserve University form research consortium 2Cleveland Clinic, Case Western Reserve University form research consortium 3The right recipe: Engineering research improves laser detectors, batteries 2The right recipe: Engineering research improves laser detectors, batteries 3
(Date:5/1/2015)... Investor-Edge has initiated coverage ... GENE ), Agilent Technologies Inc. (NYSE: ... TMO ), Sequenom Inc. (NASDAQ: SQNM ), ... research report on Genetic Technologies can be accessed ... 2015, the NASDAQ Composite ended at 4,941.42, down ...
(Date:4/30/2015)... , April 30, 2015  Roka Bioscience, Inc. (NASDAQ: ... providing advanced testing solutions for the detection of foodborne ... the first quarter of 2015 on May 7, 2015 ... Roka Bioscience will also host a conference call at ... discuss its first quarter financial results. During the conference ...
(Date:4/30/2015)... 30, 2015 Oxford Finance LLC ("Oxford"), a ... sciences and healthcare services companies, today announced the closing ... with Celula, Inc., a diagnostic testing company focused on ... patient care and improved outcomes.  Proceeds of the loan ... the commercialization of its products in the U.S. and ...
(Date:4/30/2015)... MENLO PARK, Calif. , April 30, 2015 /PRNewswire/ ... company in the emerging field of regenerative medicine, today ... operating results on Thursday, May 7, 2015 after the ... host a conference call and webcast on Thursday, May ... Pacific to discuss the results and recent corporate developments. ...
Breaking Biology Technology:Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 2Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 3Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 4Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 5Roka Bioscience to Report First Quarter 2015 Financial Results On May 7, 2015 2Oxford Finance Provides $10 Million Debt Financing to Celula 2Asterias Biotherapeutics to Report First Quarter Results on May 7, 2015 2Asterias Biotherapeutics to Report First Quarter Results on May 7, 2015 3
... $5 million in a funding round led by Kegonsa ... funding will allow Jellyfish to ramp up customer adoption of ... funding, retail industry veteran Ralph Dillon, managing member of Clyde ... ,Jellyfish has gained traction in online retailing with a shopping ...
... To perfect a technology that allows researchers to test new ... money. And fortunately for one local company, the federal government ... an endeavor. , ,To improve its technology, InvivoSciences, LLC ... from the National Center for Complementary and Alternative Medicine ...
... Wauwatosa, Wis - A research team at the ... million project grant from the National Heart, Lung, and ... bleeding disorder. , ,The funding, which was awarded to an ... used to improve both the molecular and clinical understanding of ...
Cached Biology Technology:Online retailer Jellyfish.com lands $5M in funding 2Online retailer Jellyfish.com lands $5M in funding 3InvivoSciences receives NIH grant for heart technology 2Medical College secures $9.7M research grant 2
... The antiserum has been tested on tissue ... staining pattern obtained with AB1773 corresponds to ... with probes to GLYT2 mRNA and to ... Preabsorption of the antiserum with the immunogen ...
Mouse monoclonal [RIZ1723] to PRDM2/RIZ...
... OA-Hy cis- 9-Octadecenoyl-N-hydroxylamide ... LIGHT. PACKAGED UNDER INERT GAS. A potent ... dose-dependent manner (K i = 1.7 ... Soluble in EtOH or DMSO. Unstable in ...
... Reacts with an early protein. ... 3 hours post-infection exhibiting an ... peak intensity between 6-24 hours. ... intense coarsely granular staining. ...
Biology Products: