Navigation Links
Princeton research: In the early life of an embryo, a monster lurks
Date:8/22/2011

Research based at Princeton University has revealed that newly fertilized cells only narrowly avoid degenerating into fatal chaos. At the same time, scientists have discovered that embryos have acquired a mechanism to contain this dangerous instability, a finding that could help biologists unravel other mysteries about the first hours of life.

A team led by Princeton Professor of Molecular Biology Ned Wingreen reported recently in the journal PLoS Computational Biology that contrary to the idea that embryonic cells develop in natural synchrony, they are prone to descend into disarray. Without stabilization, cells develop on different schedules, and many stop developing altogether, which threatens the embryo's survival.

This lurking state of disorder was revealed through computational models the researchers constructed of the embryo cell cycle. The cell cycle is the repeated division and duplication of cells that transforms a single fertilized egg into a full-grown organism. Scientists already knew that embryonic cell cycles are initiated by a swift wave of calcium that emanates from the fertilization site and prompts the embryo's cells to divide and duplicate -- or oscillate, in biological terms.

A natural assumption among scientists had been that once initiated, the impulse to oscillate would ripple across the embryo -- which begins as one big cell that then divides repeatedly -- and set the stage for multiple rounds of cell division to occur in sync. Wingreen and his colleagues found, however, that the natural spread of oscillation is unstable and would result in an erratic patchwork of missed and incomplete cell divisions. They predicted that cell activity instead has to be triggered throughout the embryo at almost exactly the same time.

The researchers' simulation produced the first indication that the fast-moving calcium wave known to spark cell division doubles as a synchronizer that sets cells to the same deve
'/>"/>

Contact: Morgan Kelly
mgnkelly@princeton.edu
609-258-5729
Princeton University
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. Princeton scientists construct synthetic proteins that sustain life
2. Princeton researchers find that high-fructose corn syrup prompts considerably more weight gain
3. Princeton scientists find way to catalog all that goes wrong in a cancer cell
4. NCI awards $15.2 million to create Princeton Physical Sciences -- Oncology Center
5. Princeton team learns why some drugs pack such a punch
6. Princeton teams analysis of flu virus could lead to better vaccines
7. Princeton geoscientist offers new evidence that meteorite did not wipe out dinosaurs
8. Princeton researchers discover new type of laser
9. Princeton-led team finds secret ingredient for the health of tropical rainforests
10. MS research: Myelin influences how brain cells send signals
11. USC research: Cancer cells and stem cells share same origin
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... NEW YORK , Dec. 15, 2014  HITLAB SM ... Practices (GCP) audit to confirm its adherence to current ... enables HITLAB to conduct regulated smart device and smart ... safety and research quality. "HITLAB is determined ...
(Date:12/17/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/9zq33j/global_chemical ) ... Sensor Market 2015-2019" report to their offering. ... major trend upcoming in this market is the increasing ... help in recording of patient data for quick and ...
(Date:12/15/2014)... Dec. 12, 2014 Research and Markets ( ... "Global Facial Recognition Market 2015-2019" report to their ... Facial recognition is a technology used for the ... facial feature of a person such as nose, jaw ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3
... 23, 2011 Employing technology that reads the entire ... Institute (TGen) and the Technical University of Denmark (DTU) ... Haiti that killed more than 6,000 people and sickened ... the billions of chemical bases in DNA, TGen and ...
... have discovered that bacteria like E. coli and Salmonella have ... to boost their chances for infection. It,s a fascinating ... the Aug. 14 issue of Nature Chemical Biology. ... and their proteins to gain strength. ,The team includes ...
... -- Aug. 22, 2011 -- Researchers at the Joslin Diabetes ... of cells is decreased in the skeletal muscle of those ... of drugs to boost the activity of this enzyme in ... published online today in the Proceedings of the National Academy ...
Cached Biology News:TGen and DTU researchers track source of Haitian cholera outbreak 2TGen and DTU researchers track source of Haitian cholera outbreak 3Newfound hijacked proteins linked to salmonella virulence 2Joslin researchers identify new target for treatment of type 2 diabetes and prediabetes 2
(Date:1/22/2015)... (PRWEB) January 22, 2015 Eckert & ... Mass Spectrometry (AMS) services to the pharmaceutical and biotech ... joined the company in the position of Director of ... of broad and valuable experience in drug metabolism and ...
(Date:1/22/2015)... , Jan. 22, 2015  Transwestern | RBJ today announces the ... office space for Shire a leading biopharmaceutical company, at Two ... | RBJ,s Robert Richards , president, and Brian ... for the entire five-floor building at 95 Hayden Ave. ...
(Date:1/22/2015)... 22, 2015  Transwestern | RBJ today announces the firm brokered ... for Shire a leading biopharmaceutical company, at Two Ledgemont Center ... Robert Richards , president, and Brian Cohen , ... entire five-floor building at 95 Hayden Ave. Photo ...
(Date:1/22/2015)... laboratory information management systems market is a rapidly growing ... due to factors such as rising pressure to comply ... and increasing government support for adoption of HCIT solutions ... the market focus on technological advancements to further the ...
Breaking Biology Technology:Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 2Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 3Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 3Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 4
... PARIS and KYOTO, Japan, Oct. 25 Cellectis (Alternext: ... for iPS Cells Research and Application (CiRA) of Kyoto ... started a scientific collaboration to combine Cellectis, genome engineering ... to improve the natural characteristics of iPS cells for ...
... PITTSBURGH, Oct. 22 Mylan Inc. (Nasdaq: MYL ... have awarded a collective $1.25 million to support two prominent ... Arts and Sciences of West Virginia and the State of ... Bresch, Mylan,s president and a member of Mylan Charitable Foundation,s ...
... 700 Companies With 1.400 Participants Attend BioSpain 2010 -- MADRID, October 22, 2010 ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... ""; BitlyCB.alertResponse = function(data) { var s = ,; var first_result; // Results are keyed by longUrl, so we ...
Cached Biology Technology:Cellectis and the Center for iPS Cells Research and Application Enter Collaboration 2Cellectis and the Center for iPS Cells Research and Application Enter Collaboration 3Mylan and Mylan Charitable Foundation Award a Collective $1.25 Million to Prominent West Virginia Cultural Institutions 2700 Companies With 1.400 Participants Attend BioSpain 2010 2700 Companies With 1.400 Participants Attend BioSpain 2010 3700 Companies With 1.400 Participants Attend BioSpain 2010 4700 Companies With 1.400 Participants Attend BioSpain 2010 5700 Companies With 1.400 Participants Attend BioSpain 2010 6700 Companies With 1.400 Participants Attend BioSpain 2010 7