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Priming 'cocktail' shows promise as cardiac stem cell grafting tool
Date:12/5/2013

istic effect."

In the study, Spees and colleagues compared the impact of sending a cardiac stem cell "naked" into a rodent heart with infarction (heart attack) to a cell that instead wore a "backpack" of protective ligands, created by incubating about 125,000 cardiac cells in a "cocktail" of CTGF and insulin on ice for 30 minutes. The team grafted the cells sub-epicardially between the outer layer and the muscle tissue of the heart and found that their priming cocktail resulted in improved graft success.

"We broke the record for engraftment!" exclaims Spees, who adds that the team's priming tool named "Cell-Kro" dramatically increases cell adhesion, proliferation, survival, and migration.

While Spees and his colleagues continue to study grafting with cardiac stem cells from rats, the future could include human cardiac stem cells and human trials.

"There are about 650,000 bypass surgeries annually," says Spees. "These patients could have cells harvested at their first surgery and banked for future application. If they return for another procedure, they could then receive a graft of their own cardiac progenitor cells, primed in Cell-Kro, and potentially re-build part of their injured heart."


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Contact: Jennifer Nachbur
jennifer.nachbur@uvm.edu
802-656-7875
University of Vermont
Source:Eurekalert

Page: 1 2

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