Navigation Links
'Prima donna' protein doesn't work well in pairs
Date:11/5/2010

HOUSTON -- (Nov. 5, 2010) -- A new study by Rice University bioengineers finds that the workhorse proteins that move cargo inside living cells behave like prima donnas. The protein, called kinesin, is a two-legged molecular machine. Rice's scientists invented tools that could measure the pulling power of kinesin both singly and in pairs, and they report this week in Biophysical Journal that kinesins don't work well together -- in part because they are so effective on their own.

"Researchers have been investigating the mechanical properties of individual motor proteins for some time now, but this is the first time anyone's been able to tie a defined number of molecular motors to a cargo and watch them work together," said lead researcher Michael Diehl, assistant professor in bioengineering at Rice. "We know that more than one of these motors is attached to most cargoes, so understanding how they work together -- or fail to -- is a key to better understanding the intracellular transport system."

Cargoes inside cells are hitched to teams of motor proteins and hauled from place to place like horse-drawn wagons. Like stagecoaches or wagons, many cargoes are pulled by several horses. But unlike a wagon, cellular cargoes often also have multiple teams pulling in opposite directions.

"Motor proteins move directionally," Diehl said. "They either move toward the cell's nucleus or they move away from the nucleus toward the periphery. Grouping different types of motors together allows cells to regulate cargo movement. But when there are multiple motors pulling antagonistically in opposite directions, what determines which group wins? What influences the balance? How do they cooperate or compete to get the right packages to the right place? Those are the kinds questions we're trying to answer."

Diehl said intracellular transport has become an increasingly hot topic over the past decade, in part because researchers have found that
'/>"/>

Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Novel antisense therapies protect primates from lethal Ebola and Marburg viruses
2. Fossil find puts a face on early primates
3. Delineating primary and secondary organic carbon in neoproterozoic glacial sediments
4. Odd mosaic of dental features reveals undocumented primate
5. Primary Energy Reports Improved First Quarter Results
6. Discovery of a primate more than 11 million years old
7. Primary cilia formation provides insight into genetic diseases
8. Primary product
9. New theory on the origin of primates
10. Hyenas cooperate, problem-solve better than primates
11. Some skin cancer may be mediated by primary cilia activity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Prima donna' protein doesn't work well in pairs
(Date:12/10/2014)... N.C. , Dec. 9, 2014  Valencell, a ... it is seeing a staggering demand from its licensees ... the Company revealed, is not solely coming from fitness ... as well. "A wearable is only as ... result, accuracy is the ultimate driver in long-term mass ...
(Date:12/5/2014)... Dec. 4, 2014 Increased emphasis on ... in new testing and inspection technologies. The convergence ... to a range of innovative test solutions. This ... Generation Y, which is generally more inclined towards ... product development strategies of test equipment vendors will ...
(Date:11/21/2014)... DALLAS , November 18, 2014 ... Security Systems Market by Systems (Video, RFID, Access Control, ... (SEZ, Factories, Hotels, Banks, Government), Component Service Geography - ... Security Systems Market is projected to be around $25 ... Billion by 2020, growing at a CAGR of 8.69%. ...
Breaking Biology News(10 mins):Wearable Technology Products Demand Highly Accurate Biometric Technology 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3
... German . , Is the vacuum-packed chicken ... tell the whole story. And the "best-before" date is no ... added to the uncertainty, and the customer him- or herself ... is an area in which a sensor film developed by ...
... first indigenous micro-satellite, X-SAT, lifted off on board India,s ... Time (12.42pm, Singapore time) on 20 April 2011. ... Technological University (NTU), in collaboration with DSO National Laboratories, ... Sriharikota in Andhra Pradesh, India. The wholly ...
... The Wistar Institute have found a new way to force ... currently in development, called Gamitrinib, sensitize tumor cells to a ... development as part of an anticancer regimen. ... April issue of the Journal for Clinical Investigation, ...
Cached Biology News:Rotten meat doesn't stand a chance 2Singapore's first locally made satellite launched into space 2Exploiting the stress response to detonate mitochondria in cancer cells 2Exploiting the stress response to detonate mitochondria in cancer cells 3
(Date:12/24/2014)... Fla. , Dec. 23, 2014  Rock Creek ... that it has filed a Clinical Trial Application (CTA) ... Healthcare products Regulatory Agency (MHRA) seeking regulatory approval to ... lead molecule, Anatabine Citrate. Contingent on the ... conduct a Phase I trial to assess the safety, ...
(Date:12/22/2014)... - RepliCel Life Sciences Inc. (OTCQB: REPCF) (TSX.V: RP), ... development of autologous cell therapies, announced today the publication ... in conjunction with co-authors from Kyoto University and the ... ongoing clinical research using dermal sheath cup (DSC) cells ... The paper entitled " Hair Follicle Dermal Stem Cells ...
(Date:12/22/2014)... The American Journal of Hematology/Oncology, ... and editorials addressing developments and pathways related to ... provocative article exploring the role of follicle-stimulating hormone ... of prostate cancer. , The article references ... that there could be a connection to prostate ...
(Date:12/19/2014)... Charm Sciences is pleased to announce that its ... M1 in raw commingled milk is the first lateral ... peer reviewed report of the validation by Technology and ... Fisheries Research (ILVO-T&V) has been published by the Taylor ... toxic aflatoxin and a known carcinogen, can be passed ...
Breaking Biology Technology:Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 2Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 4Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 5Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 2Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 3Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 4Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2
... ... and play" medical camera during an operation he performed for his Discovery Channel television ... ... the Dr. Oz Show used VizVOCUS,s popular "plug and play" medical ...
... CAMBRIDGE, England , May 25, 2010 ... UK ) announced today,an extension of the agreement under which O2h provides ... , , ... Congreve , Head of Chemistry said, "We are happy to have signed,this ...
... China , May 25 /PRNewswire-Asia-FirstCall/ -- Biostar,Pharmaceuticals, Inc. ... a leading over-the-counter Hepatitis B medicine,Xin Aoxing Oleanolic Acid Capsule ("Xin ... that it has,commenced assembly of its production line for its proprietary ... , ...
Cached Biology Technology:VizVOCUS's Digital Camera Used by Dr. Mehmet Oz on Discovery Channel Special 2Heptares Therapeutics Extends Multi-FTE Chemistry Collaboration With Oxygen Healthcare (O2h) 2Heptares Therapeutics Extends Multi-FTE Chemistry Collaboration With Oxygen Healthcare (O2h) 3Biostar Pharmaceuticals, Inc. Begins Assembly of New Production Line 2Biostar Pharmaceuticals, Inc. Begins Assembly of New Production Line 3Biostar Pharmaceuticals, Inc. Begins Assembly of New Production Line 4
PC based system for advanced chemifluorescent, chemiluminescent, fluorescent and colorimetric, microarray and microscope imaging and analysis....
Pendrin (H-195)...
... A thermostable, thermoactive designer enzyme that ... AccuRT RNA PCR enzyme allows reverse ... performed at elevated temperatures (65C), which ... the template and results in highly ...
HLA-DRbeta (DA2)...
Biology Products: