Navigation Links
Preventive detention for oxidizing agents
Date:12/17/2012

Oxidative stress is believed to cause a number of diseases. Up to now, it has been common practice to measure oxidative stress levels by determining the oxidation state of a small molecule called glutathione in cell extracts. Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have been the first to discover that cells under stress deposit their oxidized glutathione in a cellular waste repository. This protects cells from oxidative stress and questions the validity of the conventional measuring method.

Cancer, Alzheimer's, arteriosclerosis the list of diseases which have been linked to oxidative stress is long and even includes the very process of aging. Oxidative stress is caused by so-called reactive oxygen compounds, which include the notorious "free radicals". If a cell is exposed to more reactive oxygen compounds than it can instantly degrade, it is under oxidative stress. As a result, important components such as proteins, DNA and lipids are oxidized and thus get damaged.

To determine whether a cell is under oxidative stress, scientists often analyze the oxidation state of glutathione. Glutathione is a small molecule which gets oxidized to protect the cell from reactive oxygen compounds. In theory, the amount of oxidized glutathione should therefore indicate whether a cell is healthy or under oxidative stress. However, researchers in the team of Associate Professor (PD) Dr. Tobias Dick have demonstrated that this hypothesis, which is the basis of a large number of scientific studies, is deceptive.

"Up to now, it was necessary to destroy the cells in order to measure the amount of oxidized glutathione," Tobias Dick explains. "However, this means that any spatial resolution is lost." Therefore, virtually nothing was known about where exactly oxidized glutathione is found in the cells. Scientists have presumed that it remains in the cytoplasm, where it is formed.

To find out more
'/>"/>

Contact: Dr. Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. Understanding the RNAi Reagents Market Overlap with Drug Discovery and Therapeutic Development is Critical for Pharmaceutical Leaders
2. Boston subway system to be used to test new sensors for biological agents
3. Project MICREAgents: Self-assembling smart microscopic reagents to pioneer pourable electronics
4. Novel non-antibiotic agents against MRSA and common strep infections
5. Production of FRP components without release agents
6. Developing second skin military fabric to repel chemical and biological agents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/18/2013)... been awarded a $394,300 grant from the Tarrant ... flow in the new facilities of the 150-mile ... associate professor of civil engineering, will investigate the ... the water in an effort to eliminate biological ... Adding monochloramine is widely practiced throughout the United ...
(Date:6/18/2013)... National Institutes of Health has awarded $12.7 million ... selection of pharmaceutical industry compounds to explore new ... Alzheimer,s disease, Duchenne muscular dystrophy and schizophrenia. The ... for Existing Molecules, is led by the National ... by the NIH Common Fund. , The process ...
(Date:6/18/2013)... 5% and 10% of breast and ovarian cancers are ... tumours are attributable to inherited mutations from the parents ... with these mutations, PARP inhibitors, which are currently in ... a new option for personalised cancer treatment, an alternative ... a fraction of these patients generate resistance to the ...
Breaking Biology News(10 mins):UT Arlington research to benefit quality, flow in 150-mile Integrated Pipeline 2NIH to fund collaborations with industry to identify new uses for existing compounds 2NIH to fund collaborations with industry to identify new uses for existing compounds 3NIH to fund collaborations with industry to identify new uses for existing compounds 4An article in 'Cell' reveals a new resistance mechanism to chemotherapy in breast and ovarian cancer 2
... demonstrated the role of a gene important to the ... requires coordination of differentiation of immature neural cells with ... Until now, the mechanisms regulating these distinct cellular activities ... be published in the Feb. 15 issue of Development. ...
... hunting among chimpanzees is a group effort, key males, known ... are more likely to initiate a hunt, and hunts rarely ... The findings, which appear in the current issue of Animal ... to hunt for food, and how individual variation among chimpanzees ...
... more sensitive and more accurate than conventional imaging methods ... to a UCLA study that is among the first ... study has important implications for patients. If conventional imaging ... that in fact are working and study participants may ...
Cached Biology News:Trainor Lab characterizes gene essential for prenatal development of nervous system 2Key 'impact hunters' catalyze hunting among male chimpanzees 2Key 'impact hunters' catalyze hunting among male chimpanzees 3Positron emission tomography superior to standard evaluation tools in measuring treatment response 2Positron emission tomography superior to standard evaluation tools in measuring treatment response 3
(Date:6/18/2013)... (Monday, June 17, 2013) A million electric cars could ... the decade with the help of research by the United ... University of Waterloo. , Professor Zhongwei Chen is part of ... to develop non-precious materials to replace the expensive platinum catalysts ... the adoption of fuel cells in vehicles is the cost ...
(Date:6/18/2013)... (PRWEB) June 18, 2013 (PRWEB) June 18, 2013 ... time and attendance system in North America, has ... shares employee data and payroll records between ExakTime’s ... Plus automates ExakTime software setup and keeps ... imports employee data from a business’ current payroll ...
(Date:6/18/2013)... The human skin is the largest organ, yet ... body part. Similar to the liver, or heart, the skin ... and grow. Recent reports from the mankatofreepress.com explained how caring ... important as other life supporting organs. The article suggests several ... reproduction, increase the appearance of skin, and fight off acne ...
(Date:6/18/2013)... , June 18, 2013 ... using the company,s  proprietary AMCA Guided Bone Regeneration (GBR) Dental ... implants. A common problem encountered when patients have ... of sufficient bone volume to house the implant. Consequently there ... bone substitute until the natural bone regenerates. The bone substitute ...
Breaking Biology Technology:US and Canadian researchers drive towards cheaper fuel cells for electric cars 2ExakTime Introduces AccountLinx Plus 2Natural Acne Remedies Through Diet, Probiotic Action Shares New Insight on What Foods May Help Lead to Clear Skin 2RegeneCure Starts Clinical Study Using Polymeric Bone Stimulating Membrane for Dental Implants 2RegeneCure Starts Clinical Study Using Polymeric Bone Stimulating Membrane for Dental Implants 3
... CITY, June 24 /PRNewswire-FirstCall/ - AEterna Zentaris Inc. ... global biopharmaceutical company focused on endocrine therapy and ... previously announced registered direct offering of US$10 million ... share purchase warrants to certain institutional investors. AEterna ...
... June 24 International Products Corporation,s ( ... performing filter membrane compatibility and performance ... the ability to evaluate any type of membrane media, from ... President, Kathy Wyrofsky. "Our goal is to be able ...
... ... that it provided the Helsinn Group with the transaction advisory support for the successful ... on Monday. Full details of this transaction can be found at http://www.prnewswire.co.uk/cgi/news/release?id=259822 . ... Oxford, UK ...
Cached Biology Technology:AEterna Zentaris Receives US$10 Million from Institutional Investors 2AEterna Zentaris Receives US$10 Million from Institutional Investors 3International Products Corp.'s Lab Offers Filter Membrane Compatibility and Studies 2PharmaVentures Assists Helsinn in the Successful Sale of Helsinn Chemicals Ireland to the Medinco C.F.M. Group 2
... Microarrays designed for proteomic scale kinase ... activities, and drug discovery research built ... microfluidic on-chip synthesis platform. These microarrays ... comprehensive Protein Kinase Substrate - Peptide ...
... Western blotting is a commonly used technique ... protein samples are electrophoresed on SDS-PAGE and ... or nylon, where they are probed with ... which allow reuse of Southern and Northern ...
... for immunological studies, vaccine development, and ... and powerful Paraflo microfluidic on-chip synthesis ... part of our comprehensive Epitope Peptide ... Content Probe content is completely ...
... built on the flexible and powerful ... microarrays are available as part of ... Custom Probe Content ... Thousands of customer specified peptide sequences ...
Biology Products: