Navigation Links
Preventing prostate cancer through androgen deprivation may have harmful effects
Date:12/20/2012

PHILADELPHIA The use of androgen deprivation therapies to prevent precancerous prostate abnormalities developing into aggressive prostate cancer may have adverse effects in men with precancers with specific genetic alterations, according to data from a preclinical study recently published in Cancer Discovery, a journal of the American Association for Cancer Research.

"The growth and survival of prostate cancer cells are very dependent on signals that the cancer cells receive from a group of hormones, called androgens, which includes testosterone," said Thomas R. Roberts, Ph.D., co-chair of the Department of Cancer Biology at the Dana-Farber Cancer Institute and professor of biological chemistry and molecular pharmacology at Harvard Medical School in Boston, Mass.

Previous findings from two major randomized, placebo-controlled prostate cancer chemoprevention trials revealed that androgen deprivation therapy reduced the overall risk for low-grade prostate cancer. However, both trials also revealed a high cumulative risk for high-grade prostate cancers that has caused concern among experts.

High-grade prostatic intraepithelial neoplasia is a prostate abnormality that is considered to be a major precursor to prostate cancer. Loss of the tumor suppressor PTEN is detected in 9 to 45 percent of clinical cases.

Using a mouse model of PTEN-driven high-grade prostatic intraepithelial neoplasia, Roberts and his colleagues investigated whether surgical or chemical androgen deprivation could prevent the cancer precursor from progressing to more aggressive disease.

"When we castrated the animals, we thought the tumors would shrink and they did initially," Roberts said. "However, they then grew back and became invasive."

The results of this preclinical study suggest that prophylactic reduction of the most active form of androgen, or blocking androgen receptor function, might have unintended consequences in so
'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Preventing home invasions means fighting side-by-side for coral-dwelling crabs and shrimp
2. Preventing the immune system from going haywire during sepsis
3. Limiting TV time -- Effective strategy for preventing weight gain in children
4. New study to examine ecological tipping points in hopes of preventing them
5. Microscopic packets of stem cell factors could be key to preventing lung disease in babies
6. Marshall University study may lead to new treatments for prostate cancer
7. Interventional radiology: Potential breakthrough to treat mens enlarged prostate
8. Tokai Pharmaceuticals galeterone well-tolerated in patients with advanced prostate cancer
9. Study shows botanical formula fights prostate cancer
10. New diagnostic tool determines aggressiveness of prostate cancer
11. Beehive extract shows potential as prostate cancer treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... A new report from the Wildlife Conservation Society ... only help economically valuable species such as lobster, ... also help re-colonize nearby reef areas. , The ... a systematic review of research literature from no-take ... by Dr. Craig Dahlgren, a recognized expert in ...
(Date:7/11/2014)... 11, 2014--Researchers at the Department of Energy,s Oak ... awards, presented by R&D Magazine in recognition of ... awards recognize the tremendous value of our National ... and development at the National Labs continues to ... pursue the scientific and technological innovations necessary to ...
(Date:7/11/2014)... in eastern New South Wales, Australia when NASA,s Aqua ... UTC on July 11 (12:35 p.m. local time/11:35 p.m. ... New South Wales (NSW), the Moderate Resolution Imaging Spectroradiometer ... region and spotted smoke (light brown) from various fires. ... outlined in red. , The New South Wales, Australia ...
Breaking Biology News(10 mins):Belize's lobster, conch, and fish populations rebuild in no-take zones 2ORNL wins eight R&D 100s 2ORNL wins eight R&D 100s 3ORNL wins eight R&D 100s 4
... researchers have discovered that a recently identified protein critical ... keep its repairs accurate. , The protein, called ... proteins known as DNA polymerases that are vital for ... other DNA-repair proteins insure their accuracy with the help ...
... sheds light on the molecular mechanisms underlying axon growth ... a study published today in the open access journal ... UNC-69, required for proper locomotion . They show that ... to be involved in the trafficking of vesicles along ...
... Portabella and crimini mushrooms rank with carrots, green beans, ... antioxidants, Penn State researchers say. , Dr. N. Joy ... at Penn State, measured the activity of two antioxidants, ... assay and HPLC instrumentation, as part of her dissertation ...
Cached Biology News:Unusual mechanism keeps repair protein accurate 2Unusual mechanism keeps repair protein accurate 3Newly identified protein complex sheds light on axon growth mechanism 2Mushrooms as good an antioxidant source as more colorful veggies 2
(Date:7/11/2014)... Cayenne Medical, Inc., a privately ... soft tissue reconstruction segment, announced the worldwide launch ... involving the shoulder and extremities. The SureLock System ... deployment method. The unique delivery eliminates manual tensioning ... or anchor displacement (also commonly know as anchor ...
(Date:7/10/2014)... 2014 Terascala, the industry leader in ... Swahn, a former vice president of product management for ... president of marketing. Terascala’s software when combined with leading ... the highest performance and most reliable solutions for processing ... Terascala’s channel expansion and broaden its product portfolio. His ...
(Date:7/10/2014)... CA (PRWEB) July 10, 2014 Senior ... institutions and professional associations, addressed the challenges of “Reducing ... Medical Device Industries” through strategic sourcing. Describing the partnership ... with the Supply Chain Management Institute ( SCMI) ... event on June 24 at the Kroc Institute of ...
(Date:7/10/2014)... , July 10, 2014 Research and ... of the "International Photonic Integrated Circuit (Monolithic ... to 2019" report to their offering. ... The concept of photonic integration traces its roots ... The promise of photonic integration went unexplored and ...
Breaking Biology Technology:Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 3Terascala Expands Executive Team 2Terascala Expands Executive Team 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2
... body of an ordinary family car consists of 193 different ... car has been carefully selected and optimised. It is important, ... because of the fuel consumption, whereas other parts of the ... passengers in a collision. Super strong nanostructured metals ...
... 21, 2011 ViroPharma Incorporated,s (Nasdaq: VPHM ) ... released on Thursday, July 28, 2011 before the open of ... a conference call and live audio webcast at 9:00 a.m. ... ViroPharma management will discuss the 2011 second quarter financial results ...
... Inc. (OTC/BB: GNBP), a biotechnology company developing targeted cancer ... Merrill A. McPeak to its Board of Directors.  General ... Force and was USAF chief of staff from 1990 ... 7 members, including 5 independent directors. "General ...
Cached Biology Technology:A new discovery paves the way for using super strong nanostructured metals in cars 2A new discovery paves the way for using super strong nanostructured metals in cars 3ViroPharma to Release 2011 Second Quarter Financial Results on July 28, 2011 2Genesis Biopharma Names Former Member of the Joint Chiefs of Staff General Merrill McPeak to Board of Directors 2
... scientists developed the Easy-Titer Human IgM Assay ... simple, sensitive, and easy-to-perform assay for Human ... ELISA. This kit incorporates a simple mix-and-read ... IgM concentration from 15-500 ng/ml in approximately ...
... clarification reagent; Ideal for clarifying many ... proteins, nucleic acids, & proteoglycans; Contains ... improves downstream processing; Utilizes a reagent ... supplied as a suspension in saline; ...
A simple, sensitive and reliable method for determining free sulfhydryl content in peptides, protein...
... true benchtop incubator-shaker, has the smallest footprint of ... of 540 x 680 mm (W x D) ... x 505 x 510mm). Available in 25 mm ... ideal for shaking applications requiring controlled speed and ...
Biology Products: