Navigation Links
Preventing or reversing inflammation after heart attack, stroke may require 2-pronged approach
Date:2/28/2010

ese findings suggest other pathways are needed for Src to change permeability and open the door to future studies to determine what these other signals are."

There are many "adhesion molecules" involved in holding endothelial cells together and many signaling molecules that tell the adhesion molecules when to hold onto or release each other. Vincent's team is moving forward with what he calls a "two-hit model" the idea that endothelial cells require two different signals to open up cell-cell connections and allow the passage of fluids.

"Many factors lead to a complex array of signals inside the endothelial cells to promote this loss of barrier function," Adam said. "A two-hit model would explain much better than a single-hit model the regulation of the vascular permeability. On the pharmacological side, it would allow us to propose other drug targets to prevent or reverse inflammation and edema."

By being named a "Paper of the Week" by the Journal of Biological Chemistry, the article by Adam and Vincent, graduate student Amy L. Sharenko and associate professor Kevin Pumiglia has been categorized in the top 1 percent of papers reviewed by the journal's editorial board in terms of significance and overall importance.


'/>"/>

Contact: Angela Hopp
ahopp@asbmb.org
301-634-7389
American Society for Biochemistry and Molecular Biology
Source:Eurekalert  

Page: 1 2

Related biology news :

1. New finding in cell migration may be key to preventing clots, cancer spread
2. UC Davis research confirms benefits of calcium and vitamin D in preventing fractures
3. New study suggests minke whales are not preventing recovery of larger whales
4. Mango effective in preventing, stopping certain colon, breast cancer cells
5. Preventing allergies
6. Climate change poker: The barriers which are preventing a global agreement
7. NIH funds work at WPI on regenerating heart tissue and preventing urinary tract infections
8. Preventing ear infections in the future: Delivering vaccine through the skin
9. Bacteria play role in preventing spread of malaria
10. ORNL, Southern Cal set sights on preventing blindness
11. Preventing rangeland erosion: Developing better management practices in Iran
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Preventing or reversing inflammation after heart attack, stroke may require 2-pronged approach
(Date:7/24/2014)... molecules, which have similar counterparts in humans, affect the ... nerve signals into the hippocampus, an area of the ... and the creation of memories. The results of the ... . , Brain function depends on the active communication ... neurons are woven together into a dense network where ...
(Date:7/24/2014)... biodiversity and one of the most species richness biome ... However, current levels of diversity might be still underestimated. ... in the description of new endemic species of this ... availability of samples for DNA analysis. , Using ... morphological analysis, researchers from the University of Richmond ...
(Date:7/24/2014)... 24, 2014) For years, researchers and patients have ... any cell type in the bodycould provide insight into ... Yet progress has been hampered by the inability to ... their human counterparts, in part because human ESCs are ... , Now Thorold Theunissen, Benjamin Powell, and Haoyi Wang, ...
Breaking Biology News(10 mins):A protein couple controls flow of information into the brain's memory center 2A protein couple controls flow of information into the brain's memory center 3A protein couple controls flow of information into the brain's memory center 4A tiny new species of frog from Brazil with a heroic name 2Whitehead Institute researchers create 'naïve' pluripotent human embryonic stem cells 2
... YORK (Embargoed until September 14, 2010: 5:00 p.m. U.S. ... Conservation Society and other groups reveals an ominous finding: ... overhunting, logging, and wildlife tradeare now clustered in just ... identifies 42 ,source sites, scattered across Asia that are ...
... Maryland biologists have identified how changes in both ... the Mexican blind cavefish ( Astyanax mexicanus ) ... in the August 12, 2010 online edition of ... with postdoctoral associates Masato Yoshizawa, and pela Gorički, ...
... RICHMOND, Va. (Sept. 14, 2010) An ... gene for schizophrenia, including a potentially causative mutation, ... The results of the research, led by ... human and molecular genetics in Virginia Commonwealth University,s ...
Cached Biology News:Last strongholds for tigers identified in new study 2Last strongholds for tigers identified in new study 3Adapting to darkness: How behavioral and genetic changes helped cavefish survive extreme environment 2Adapting to darkness: How behavioral and genetic changes helped cavefish survive extreme environment 3VCU study: Team uncovers possible risk gene for schizophrenia 2
(Date:7/24/2014)... 2014 Deep Research Report on ... professional and in-depth research report on Potassium Sulphate ... basic information, including its definition, classification, application, and ... covers the international market analysis, including China’s domestic ... macroeconomic environment & economic situation analysis, the influence ...
(Date:7/24/2014)... 2014 1000 balances – 4 steps ... customers’ weighing needs and expertly narrows down the mass ... scales or even terminals. , First, select the ... (or select readability instead) and define the accuracy – ... criteria narrows down the list to models that fit ...
(Date:7/24/2014)... BETHESDA, Md. , July 24, 2014  Spherix ... to the fostering and monetization of intellectual property, today ... for the period ending June 30, 2014 on Monday, ... conference call at 10 a.m. ET on Monday, August ... to be led by the company,s CEO, Anthony ...
(Date:7/24/2014)... The patent provides substantially greater ... results. It also enables true sample ID and ... reporting of high profile assays such as those ... growing area of biotechnology that includes DNA based ... companion diagnostics in personalized medicine. The new patent ...
Breaking Biology Technology:Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 4Spherix Schedules Shareholder Update Call 2New DNA-barcode Patent Virtually Eliminates False Test Results and Sample Mix-up 2
... SAN DIEGO, Oct. 24 Anadys Pharmaceuticals,Inc. (Nasdaq: ... by developing novel medicines in the areas of hepatitis ... quarter 2007 financial,results on Thursday, November 1, 2007, after ... conference call and webcast to discuss its third,quarter financial ...
... Key Factors, MUNDELEIN, Ill., Oct. 24 ... company has been awarded a hematology contract ... Systems. The,extension agreement provides MedAssets, customers access ... effective October,1, 2007, said John Kershaw, President, ...
... Oct. 24 Gene Codes Corporation, a,leading ... the next version of Sequencher, its award-winning,Deoxyribonucleic ... Researchers in academic labs and pharmaceutical ... the essential genetic instructions key to,an organism,s ...
Cached Biology Technology:Anadys Pharmaceuticals to Report Third Quarter 2007 Financial Results 2Sysmex America Awarded MedAssets Supply Chain Systems Hematology Contract Extension 2Gene Codes Corporation Announces Version 4.8 of Sequencher Software for DNA Sequence Assembly & Analysis 2
...
... licensed, high throughput, water bath thermal cycler capable ... microplates. This equates to 9,216 reactions per run ... arm rapidly transfers a basket of plates between ... that are considerably faster than those of peltier ...
anti-Yan 8B12H9...
Proliferin (N-14)...
Biology Products: