Navigation Links
Preventing ear infections in the future: Delivering vaccine through the skin
Date:5/21/2009

An experimental vaccine applied the surface of the skin appears to protect against certain types of ear infections. Scientists from the Research Institute at Nationwide Children's Hospital in Columbus, Ohio, report their findings today at the 109th General Meeting of the American Society for Microbiology in Philadelphia.

"Our data are the first to show that transcutaneous immunization is an effective way to prevent experimental ear infections and lays the foundation for an effective, yet simple, inexpensive and potentially transformative way to deliver vaccines," says Laura Novotny, one of the study researchers.

Nontypeable Haemophilus influenzae (NTHi) is one of the three main bacterial causes of otitis media (OM), an infection or inflammation of the middle ear. OM is one of the most significant health problems for children in the United States, costing approximately $5 billion annually. It is estimated that 83% of all children will experience at least one ear infection prior to 3 years of age.

Currently infections are managed with antibiotics; however, the emergence of antibiotic-resistant microorganisms is of concern. Surgery to insert tubes through the tympanic membrane relieves painful symptoms, but the procedure is invasive and requires the child to be under general anesthesia. Thus, it is necessary to develop different ways to treat or preferably prevent this disease.

"We have designed several vaccine candidates which target proteins on the outer surface of this bacterium. Previous work in our lab showed that after immunization by injection, each of the three vaccine candidates prevented experimental ear infections caused by NTHi. In this study, we now wanted to test an alternative but potentially equally effective method to deliver a vaccine," says Novotny.

The method, known as transcutaneous immunization, involved placing a droplet of each vaccine onto the ear and rubbing it into the skin.


'/>"/>
Contact: Jim Sliwa
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Preventing tuberculosis reactivation
2. Environmental epigenetics has potential for preventing and treating disease
3. Streams remove significant amounts of nitrogen, preventing downstream dead zones
4. Scientists demonstrate feasibility of preventing malaria parasite from becoming sexually mature
5. MIT: Preventing forest fires with tree power
6. Kazak apple research key to preventing blue mold
7. Preventing a broken heart: Research aims to reduce scarring from heart attacks
8. Preventing soil erosion in continuous corn
9. Fast-food diet cancels out benefits of breastfeeding in preventing asthma
10. New vaccine developed for preventing uncommon cold virus
11. Preventing rangeland erosion: Developing better management practices in Iran
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... Peru found that 28 percent of the batches ... Many pills released the active ingredient too slowly. ... had no active ingredient at all. , ... Georgia Institute of Technology developed a sophisticated approach ... drugs and then characterize their chemical composition. The ...
(Date:4/18/2014)... URBANA, Ill. For the past 20 years, researchers ... of the research findings have suggested that soil organic ... or conventional tillage systems to no-till systems. However, there ... no-till systems in corn and soybean rotations without cover ... soil organic carbon stocks at the published rates. , ...
(Date:4/18/2014)... Asteroid and comet impacts can cause widespread ecological ... even global scales. But new research from Brown University ... ancient life at the time of an impact. , ... has found fragments of leaves and preserved organic compounds ... in Argentina. The material could provide a snapshot of ...
Breaking Biology News(10 mins):Counterfeit contraceptives found in South America 2Counterfeit contraceptives found in South America 3Researchers question published no-till soil organic carbon sequestration rates 2Researchers question published no-till soil organic carbon sequestration rates 3Researchers question published no-till soil organic carbon sequestration rates 4Impact glass stores biodata for millions of years 2Impact glass stores biodata for millions of years 3
... Cincinnati, OH, April 14, 2011 -- The number of couples ... often use assisted reproductive technologies, like in vitro fertilization (IVF), ... can also increase the risk of multiple pregnancies (i.e., twins ... one embryo. Twins and triplets are likely to be ...
... hormone known to inhibit aging can also protect kidneys against ... Scientists led by Dr. Makoto Kuro-o, associate professor of pathology, ... renal fibrosis a common complication of chronic kidney disease ... online in the Journal of Biological Chemistry . ...
... and economic security concerns have triggered interest in using algae-derived ... or any other biofuel source can require a ... smart about where we grow algae can drastically reduce how ... biofuel, while being water-wise, could also help meet congressionally mandated ...
Cached Biology News:New study finds stronger regulations of in vitro fertilization may save lives 2Anti-aging hormone Klotho inhibits renal fibrosis, cancer growth 2Study: Algae could replace 17 percent of US oil imports 2Study: Algae could replace 17 percent of US oil imports 3Study: Algae could replace 17 percent of US oil imports 4
(Date:1/14/2014)... (PRWEB) January 14, 2014 Carahsoft and ... Thursday, January 23, 2014 at 2pm EST (11am PST), ... The topic focuses on how technology can turn raw, ... decisions for government agencies. The online webinar will last ...
(Date:1/14/2014)... EquitiesIQ, a leading informational research provider, has ... an emerging biomedical company acquiring, developing, manufacturing, and marketing ... Free report download: http://equitiesiq.com/reports/alliqua/ , In late ... and Board, which launched the company’s new strategy to ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 In recent ... motives and methods in product development and promotion has ... industry. This mistrust, fueled by concerns about the insidious ... by reports of spectacular fines to the world’s biggest ...
(Date:1/14/2014)... 13, 2014 Bob Hainsey, a semiconductor ... 20 years in the industry, has joined SPIE, ... will serve as the society’s Science and Technology Strategist. ... SPIE as our Technology Strategist, further strengthening the technical ...
Breaking Biology Technology:Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2
... Aoxing Pharmaceutical,Company, Inc. (OTC Bulletin Board: CAXG), which ... highly regulated narcotic,medicines and pain medication in China, ... fiscal 2008 ended September 30, 2007. China ... first quarter of fiscal 2008, a 33% sequential ...
... Convergence and New Opportunities, NEW BRUNSWICK, N.J., Nov. ... organizational changes to sharpen its,focus on opportunities outside its ... health care. These include the creation of a new,strategy ... The,changes are designed to accelerate growth for Johnson & ...
... 14 Advanced Life Sciences,Holdings, Inc. (Nasdaq: ... development and commercialization of novel drugs in the,therapeutic ... its financial results for the third quarter ended ... The net loss for the three months ended ...
Cached Biology Technology:China Aoxing Pharmaceutical Reports Financial Results for the First Quarter of Fiscal 2008 2China Aoxing Pharmaceutical Reports Financial Results for the First Quarter of Fiscal 2008 3China Aoxing Pharmaceutical Reports Financial Results for the First Quarter of Fiscal 2008 4China Aoxing Pharmaceutical Reports Financial Results for the First Quarter of Fiscal 2008 5Johnson & Johnson Announces Changes to Accelerate Growth 2Johnson & Johnson Announces Changes to Accelerate Growth 3Advanced Life Sciences Announces Third Quarter 2007 Financial Results 2Advanced Life Sciences Announces Third Quarter 2007 Financial Results 3Advanced Life Sciences Announces Third Quarter 2007 Financial Results 4Advanced Life Sciences Announces Third Quarter 2007 Financial Results 5Advanced Life Sciences Announces Third Quarter 2007 Financial Results 6Advanced Life Sciences Announces Third Quarter 2007 Financial Results 7Advanced Life Sciences Announces Third Quarter 2007 Financial Results 8Advanced Life Sciences Announces Third Quarter 2007 Financial Results 9
...
... Signet offers the most comprehensive, cost-effective ... We have incorporated unprecedented quality into ... This includes proven detection chemistries and ... the TechMate protocol. It also includes ...
... Signets Xylene Resistant (X/R) Red System ... X/R Red Activator and X/R Red ... with alkaline phosphatase to produce red ... ,Kit Contains:, , Buffer, 100 ...
Human Cell Line Slides...
Biology Products: