Navigation Links
Preventing a broken heart: Research aims to reduce scarring from heart attacks
Date:12/14/2008

MADISON A heart damaged by heart attack is usually broken, at least partially, for good. The injury causes excessive scar tissue to form, and this plays a role in permanently keeping heart muscle from working at full capacity.

Now researchers have identified a key molecule involved in controlling excessive scar tissue formation in mice following a heart attack. When they stopped the scarring from occurring, the scientists found that the animals' heart function greatly improved following the injury.

The study, by scientists at the University of Wisconsin-Madison and Cornell University, appears in Nature Cell Biology online Dec. 14, 2008.

The findings offer heartening news for the millions who have heart attacks each year and suffer from the resulting poor heart function. The study raises the hope that the outlook for people with this major disability might be markedly improved.

The scientists studied a protein, sFRP2, which they unexpectedly found to be involved in the formation of collagen, the main component of scar tissue.

"With many injuries and diseases, large amounts of collagen are formed and deposited in tissues, leading to scarring and a condition called fibrosis," explains co-author Daniel S. Greenspan, professor of pathology and laboratory medicine at the UW School of Medicine and Public Health. "Fibrosis can seriously affect the functioning of heart, lung, liver and other tissues."

Greenspan, an expert on collagen, joined with Thomas Sato of Weill Cornell Medical College to study mice that don't produce sFRP2 to understand how the protein works. When the scientists restricted blood flow to the animals' hearts, mimicking a heart attack, they found that scarring was significantly reduced in these sFRP2-free animals.

"Importantly, we found that when we reduced the level of fibrosis, heart function significantly improved in the mice," says Greenspan, also a professor of pharmacol
'/>"/>

Contact: Dian Land
dj.land@hosp.wisc.edu
608-261-1034
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2

Related biology news :

1. Kazak apple research key to preventing blue mold
2. MIT: Preventing forest fires with tree power
3. Scientists demonstrate feasibility of preventing malaria parasite from becoming sexually mature
4. Streams remove significant amounts of nitrogen, preventing downstream dead zones
5. Environmental epigenetics has potential for preventing and treating disease
6. Preventing tuberculosis reactivation
7. New journal shows half-broken gene is enough to cause cancer
8. MIT: Mending broken hearts with tissue engineering
9. Mayo Clinic research on tamoxifen leads to recommendation for CYP2D6 gene test
10. Ireland Cancer Center researcher finds most triple-negative breast cancers express muc-1 target
11. Pitt, NETL researchers report molecular chain reaction thought to be impossible
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... MD FASEB MARC (Maximizing Access to Research ... for the American College of Sports Medicine,s Conference ... 2014 in Miami, Florida. These awards are ... doctorates and scientists from underrepresented groups into the ... encourage the participation of young scientists at the ...
(Date:8/28/2014)... PA, August 28, 2014 Dyslexia, the most ... is a neurological reading disability that occurs when ... language don,t function normally. , The use of ... brain activity is disrupted in dyslexia. However, most ... number of brain regions, leaving a gap in ...
(Date:8/28/2014)... and mould in homes could pose a significant health risk ... in the Journal of Allergy and Clinical Immunology . ... eight different countries, the research has found that the presence ... in asthma sufferers, as well as increasing the likelihood of ... a team at the University of Exeter Medical School and ...
Breaking Biology News(10 mins):Dyslexic readers have disrupted network connections in the brain 2Indoor mold poses health risk to asthma sufferers 2
... HOUSTON -- (Aug. 16, 2010) -- A new ... and other human activity has completely obscured the natural ... "The natural factors that influence carbon dioxide cycling ... the radiocarbon signature of the river to reflect those ...
... of some of the most repugnant smells on earth, but ... has a sense of smell of its own. A team ... first time that bacteria have a molecular "nose" that is ... today in Biotechnology Journal , their study shows how ...
... infrared laser can make a heart beat faster. Scientists ... pulsed light can pace contractions in an avian embryonic heart, ... pacing of the embryonic heart," will be published in the ... 15, 2010. According to the scientists, this non-invasive device ...
Cached Biology News:A river flipped: Humans trump nature on Texas river 2A river flipped: Humans trump nature on Texas river 3Bacteria breakthrough is heaven scent 2A heart beats to a different drummer 2
(Date:8/28/2014)... Best Sanitizers, Inc., a leader in hand ... is asking industry professionals to prepare for fall harvest ... soap they’re currently using to the Best Sanitizers’ ... hygiene is critical to fighting cross-contamination and the spread ... criteria are identified to evaluate the effectiveness of an ...
(Date:8/28/2014)... Ind. A new research platform uses ... of tiny structures undergoing stress and heating, ... improve designs for microelectronics and batteries., This ... information about how heating and the surface ... properties. Researchers have discussed the merits of ...
(Date:8/28/2014)... Willow Grove, PA (PRWEB) August 28, 2014 ... talent, and create a culture that will allow individuals ... that are becoming increasingly important for employers looking to ... life science industries are embracing this trend, as the ... the fabric of a company, which will have real ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 Sterlitech is ... polymeric membranes to its stable of products . ... molecular weight cut-offs and include membrane filters with surface ... increase in customer demand for our membrane process testing ... variety of flat sheet membranes,” explains Sterlitech President Mark ...
Breaking Biology Technology:Best Sanitizers, Inc. Asks Food Industry Professionals: With Fall Harvest On the Way, Is Your E2 Hand Soap Up to the Task? 2New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3Sterlitech Corporation Enhances Its Selection of Flat Sheet Membrane Filters 2
... July 15 Amsterdam,Molecular Therapeutics (Euronext: AMT), a ... announced the start of a collaboration with St. ... the development,of a gene therapy treatment for Hemophilia ... commercial rights to the final product. The,combination of ...
... A report published in the July 8 issue of ... Sciences ( PNAS ) is the first to ... of tiny nanoclusters of metallic gold. The study, which ... the work of researchers at four universities on two ...
... HealthSonix, Inc.,(Pink Sheets: HSXI)(FWB:H7S) today announced that ... purchased two wholly owned,subsidiaries of HealthSonix, Inc. ... "Selling the two operating companies to Innovative ... the companies to,resume full operations and get ...
Cached Biology Technology:AMT Starts Collaboration With St. Jude Children's Research Hospital on Gene Therapy for Hemophilia B. Company Accesses Exclusive Commercial Rights to Final Therapy 2AMT Starts Collaboration With St. Jude Children's Research Hospital on Gene Therapy for Hemophilia B. Company Accesses Exclusive Commercial Rights to Final Therapy 3AMT Starts Collaboration With St. Jude Children's Research Hospital on Gene Therapy for Hemophilia B. Company Accesses Exclusive Commercial Rights to Final Therapy 4Study reveals principles behind stability and electronic properties of gold nanoclusters 2Study reveals principles behind stability and electronic properties of gold nanoclusters 3Study reveals principles behind stability and electronic properties of gold nanoclusters 4HealthSonix Sells Operating Subsidiaries to Innovative Health Sciences 2
Recognizes the 41 and 43 kDa G-proteins present in liver plasma membranes and Gq/11alpha expressed in the Sf9 insect cell expression system. Negative for recombinant G(I)alpha subtypes....
Pancreatic Cell Cryopreservation Medium (2X) is intended for the cryopreservation of LT2 Immortalized Pancreatic Mesenchymal Cells (SCR013) and VIT1 Primary Pancreatic Mesenchymal Cells (SCR014)....
LAB/Probe Mouse-Rabbit DAB Kit...
Mouse monoclonal [SH-A1] to S100 alpha ( Abpromise for all tested applications). entrezGeneID: 6271 SwissProtID: P23297...
Biology Products: