Navigation Links
Pretreatment with SSTF prevents hippocampal neuronal apoptosis due to cerebral infarction
Date:3/10/2014

Focal cerebral ischemia-reperfusion may lead to neuronal loss in the hippocampus, which is regarded as one of the basic pathological mechanisms underlying cognitive impairment. The neuronal apoptosis plays an important role in cerebral infarction, determining the number of loss of neurons and infarct volume. Growing evidence has suggested that Chinese herbs can inhibit hippocampal apoptosis caused by ischemia-reperfusion. Prof. Shumin Zhao and team from Chengde Medical College in China pretreated rats with scutellaria baicalensis stem-leaf total flavonoid (SSTF) intragastrically for 7 days before focal cerebral ischemia-reperfusion injury models were established using the suture method. The researchers found that scutellaria baicalensis stem-leaf total flavonoids reduced the infarct volume and apoptosis in hippocampal neurons, restored neurological deficits, and improved the integrity of the blood-brain barrier in rats with cerebral ischemia-reperfusion injury. Meanwhile, SSTF increased the expression of the anti-apoptotic protein Bcl-2 and decreased the expression of the pro-apoptotic protein Bax, but could not prevent apoptosis. These findings, published in the Neural Regeneration Research (Vol. 8, No. 34, 2013), exhibit that SSTF may act on multiple areas and pathways to protect rat hippocampal tissue from ischemia-reperfusion injury, and thus may be useful for the clinical prevention and treatment of ischemic brain injury.


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert  

Page: 1

Related biology news :

1. Stay-at-home transcription factor prevents neurodegeneration
2. Inhibition of enzyme NOX4 prevents liver fibrosis
3. How the tilt of a cell-surface receptor prevents cancer
4. Study pinpoints, prevents stress-induced drug relapse in rats
5. University of Montreal researchers discover how drug prevents aging and cancer progression
6. Moderate exercise not only treats, but prevents depression
7. Low-frequency rTMS prevents chronic epileptic seizure
8. Novel noninvasive therapy prevents breast cancer formation in mice
9. BUSM researchers identify genes that influence hippocampal volume
10. Study finds Western diet detrimental to fetal hippocampal tissue transplants
11. Gene transduction inhibits post-epileptic hippocampal synaptic reconstruction
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Pretreatment with SSTF prevents hippocampal neuronal apoptosis due to cerebral infarction
(Date:4/19/2017)... April 19, 2017 The global ... landscape is marked by the presence of several large ... held by five major players - 3M Cogent, NEC ... accounted for nearly 61% of the global military biometric ... in the global military biometrics market boast global presence, ...
(Date:4/11/2017)... , April 11, 2017 Crossmatch®, ... secure authentication solutions, today announced that it has ... Advanced Research Projects Activity (IARPA) to develop next-generation ... program. "Innovation has been a driving ... Thor program will allow us to innovate and ...
(Date:4/5/2017)... April 5, 2017  The Allen Institute for Cell ... Explorer: a one-of-a-kind portal and dynamic digital window into ... data, the first application of deep learning to create ... cell lines and a growing suite of powerful tools. ... these and future publicly available resources created and shared ...
Breaking Biology News(10 mins):
(Date:9/21/2017)... Norwood, MA (PRWEB) , ... September 21, 2017 ... ... its proprietary clinical client portal. Each relaunch of the portal includes new features ... biotechnology and medical device companies seek to remain at the forefront of medical ...
(Date:9/21/2017)... ... September 21, 2017 , ... ... announced the election of Paul Hermes, Entrepreneur in Residence at Medtronic, Inc., to ... has developed a proprietary, tissue-engineered scaffold for anterior cruciate ligament (ACL) reconstruction that ...
(Date:9/20/2017)... MD (PRWEB) , ... September 20, 2017 , ... ... digital pathology, and Huron Digital Pathology , a provider of whole slide ... 2017 Pathology Visions conference . The workshop, entitled “Successfully Deploying a Best-in-Class Strategy ...
(Date:9/19/2017)... SC (PRWEB) , ... September 19, 2017 , ... ... safely and accurately automates the most dangerous step of sample prep for metals ... system to provide automation at an affordable price. The system is ideal for ...
Breaking Biology Technology: