Navigation Links
Pressurized virus blasts its infectious DNA into human cells

The virus that causes those painful lip blisters known as cold sores has an internal pressure eight times higher than a car tire, and uses it to literally blast its infectious DNA into human cells, scientists are reporting in a new study. Discovery of the pressure-driven infection mechanism the first in a human virus opens the door to new treatments for viral infections, they add in a study in the Journal of the American Chemical Society.

Alex Evilevitch and colleagues point out that the viruses responsible for influenza, AIDS and other infections that affect millions of people annually are quick to develop resistance to drugs that target viral proteins. Through genetic mutations, these proteins can quickly disguise themselves and evade anti-viral drugs. That has led to a search for vulnerabilities that don't involve viral proteins. Evilevitch's team looked at the pressure inside the herpes simplex virus 1 (HSV-1), the virus that causes cold sores.

They describe how HSV-1 enters cells, docks with portals on the nucleus and injects DNA with high pressure caused by tight packing of the capsid, the tough shell that houses the viral genome. Researchers already knew that several viruses that infect bacteria, called bacteriophages, use the same high-pressure mechanism to shoot their DNA into bacteria nuclei. Evilevitch and colleagues conclude that evolution has preserved this effective technique as a key step in viral infection making it a desirable target for future treatments to defeat HSV-1 and other viruses that work the same way. The same mechanism exists in eight related viruses, including those responsible for mononucleosis and chickenpox in children, and shingles in adults. Drugs that interfere with it thus could limit "the potential for development of drug resistance that can occur due to rapid adaptive mutations of viral genomes," the scientists state.


Contact: Michael Bernstein
American Chemical Society

Page: 1

Related biology news :

1. Studies reveal structure of EV71, a virus causing childhood illnesses
2. Discovery provides blueprint for new drugs that can inhibit hepatitis C virus
3. To drive infections, a hijacking virus mimics a cells signaling system
4. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
5. Harmless human virus may be able to boost the effects of chemotherapy
6. Researchers identify Achilles heel of dengue virus, target for future vaccines
7. Recapitulation of the entire hepatitis C virus life in engineered mouse cell lines
8. BGI, GMU, Mass. Eye and Ear and OUHSC announce agreement to sequence 100 human adenoviruses
9. Berkeley Lab scientists generate electricity from viruses
10. Virus barcodes offer rapid detection of mutated strains
11. Army study: DNA vaccine and duck eggs protect against hantavirus disease
Post Your Comments:
(Date:6/15/2016)... , June 15, 2016 ... market report titled "Gesture Recognition Market by Application Market - Global ... 2016 - 2024". According to the report, the  global ... billion in 2015 and is estimated to grow ... 48.56 billion by 2024.  Increasing application ...
(Date:6/3/2016)... LONDON , June 3, 2016 /PRNewswire/ ... Transport Management) von Nepal ... ,Angebot und Lieferung hochsicherer geprägter Kennzeichen, einschließlich ... weltweit führend in der Produktion und Implementierung ... an der Ausschreibung im Januar teilgenommen, aber ...
(Date:6/1/2016)... June 1, 2016 Favorable Government ... Administration and Criminal Identification to Boost Global Biometrics System ... released TechSci Research report, " Global Biometrics Market ... Forecast and Opportunities, 2011 - 2021", the global biometrics ... 2021, on account of growing security concerns across various ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016 A person commits a ... crime scene to track the criminal down. An ... Food and Drug Administration (FDA) uses DNA evidence to track ... Sound far-fetched? It,s not. The FDA has increasingly ... support investigations of foodborne illnesses. Put as simply as possible, ...
(Date:6/23/2016)... , June, 23, 2016  The Biodesign Challenge ... envision new ways to harness living systems and biotechnology, ... Art (MoMA) in New York City ... 130 participating students, showcased projects at MoMA,s Celeste Bartos ... Paola Antonelli , MoMA,s senior curator of architecture and ...
(Date:6/23/2016)... ... ... In a new case report published today in STEM CELLS Translational Medicine, doctors ... being treated for breast cancer benefitted from an injection of stem cells derived from ... frequent side effect of cancer treatment. , Lymphedema refers to the swelling ...
(Date:6/23/2016)... On Wednesday, June 22, 2016, the ... the Dow Jones Industrial Average edged 0.27% lower to finish ... 0.17%. has initiated coverage on the following equities: Infinity ... NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ... ). Learn more about these stocks by accessing their free ...
Breaking Biology Technology: