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Presidential keynote address and new research highlights from the American Society of Pediatric Otolaryngology meeting
Date:4/24/2011

ification for tonsillectomy to improve swallowing in some pediatric patients."

Dysphagia related to tonsillar hypertrophy may be more common than previously recognized. When tonsillar hypertrophy is present in the setting of pediatric dysphagia, tonsillectomy may significantly improve swallowing-related quality of life.

Bluestone Lecture - New Breath: New Approaches to Airway Replacement and Regeneration

Presenter: Martin Birchall, MD, FRCS
Date: Saturday, April 30, 2011
Time: 9:10 9:45am

Chicago, IL The loss of a normal airway is devastating. The first stem-cell based tissue engineered airway replacement was performed in an adult in 2008 and in a child in 2010.

Following successful preclinical work by a consortium of European clinical and scientific groups, a bioreactor-based, tissue engineering protocol was developed. A cyclic detergent-enzymatic method was used to remove donor cells from human trachea, re-colonized by epithelial cells and mesenchymal stem cell (MSC)-derived chondrocytes cultured from autologous biopsies or directly by MSCs.

Segments of critical broncho and tracheo-malacia were excised from recipients, and replaced by our tissue engineered implants. Different protocols were applied in the two cases. Our adult patient remains fully active, working fulltime and caring for her two children at three years. Her lung function tests are normal for her age, and the graft has a normal appearance, mucous clearance and mechanical properties at two years. There is no serological or biopsy sign of rejection and she is without immunosuppression. At one year, our child recipient is back at school, playing and growing.

"There are many conditions in children that are not easily treated by conventional therapies. Regenerative medicine is a rapidly growing field, which offers a wide range of new approaches for these 'orphan disorders'," said study author Martin Birchall, MD. "We have used ste
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Contact: Mary Stewart
mstewart@entnet.org
703-535-3762
American Academy of Otolaryngology - Head and Neck Surgery
Source:Eurekalert

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