Navigation Links
Presence of certain antibodies signals healthier teeth and gums
Date:4/23/2008

ANN ARBOR, Mich.---Antibodies present in people with good oral health could become the first tool for dental professionals to assess a patient's probable response to periodontal disease treatments, say researchers at the University of Michigan.

The antibody is to a protein called HtpG, the bug that makes it is Porphyromonas gingivalis, an important pathogen in periodontal disease. The antibody also has potential as a vaccine candidate, according to Charles Shelburne, assistant research scientist at the U-M School of Dentistry.

Researchers discovered that the HtpG antibodies were present in much lower amounts in people with periodontal disease, and in much higher concentrations in those with healthier teeth and gums. Typically, antibodies are elevated in people with disease, because they help fight the disease.

"What has been seen in periodontal disease over the last 30-40 years is that patients with periodontal disease have higher levels of antibodies to the bacteria associated with periodontal disease, but what we know is that those antibodies aren't usually protective," said Dennis Lopatin, principal investigator and senior associate dean of the School of Dentistry. "It's like being vaccinated against the wrong strain of the flu. The healthy patient makes high levels of the antibodies but to the right part of the bug."

Not only were the HtpG antibodies present in higher amounts in people with healthier gums, those patients with the antibodies responded better to periodontal treatment, the researchers say.

"We're in a position now where we have a potential tool that gives insight as to how the patient will respond to treatment," Lopatin said. "In the United States we spend $8 billion to $12 billion a year caring for people with serious periodontal disease. From a public health standpoint, it's very important to identify those people who not only need therapy but will actually respond to a specific type of therapy."

In the long run, this could lead to early interventional therapy to prevent periodontal disease from advancing, or even starting, he says.

The other part of the question is why people with periodontal disease don't make a good immune response to HtpG, and this could connect back to current thinking that oral health influences general health.

"We want to understand how unique this mechanism is in other types of chronic infections," Lopatin said. "We'd like to think it's not a mechanism unique to just this pathogen, if it is a more common mechanism, it makes it even more interesting."


'/>"/>

Contact: Laura Bailey
baileylm@umich.edu
734-764-1552
University of Michigan
Source:Eurekalert

Related biology news :

1. Presence of gene mutation helps guide thyroid cancer treatment
2. EPFL Research Day 2008, in the presence of Al Gore
3. Uncertainty drives the evolution of cooperative breeding in birds
4. Bilberry extract -- can it help prevent certain cancers?
5. Certain diseases, birth defects may be linked to failure of protein recycling system
6. Managing uncertainty important in ecological balance: ASU researcher
7. Can certain metals repel sharks from fishing gear?
8. Synthetic molecules may be less expensive alternative to therapeutic antibodies, researchers find
9. Cell response to stress signals predicts tumors in women with common pre-breast cancer
10. Surprise in the organic orchard -- a healthier worm in the apple
11. Alternative food networks connect ethical producers and consumers and can lead to healthier eating
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... June 22, 2016 On Monday, the Department ... industry to share solutions for the Biometric Exit Program. ... and Border Protection (CBP), explains that CBP intends to ... the United States , in order ... defeat imposters. Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/20/2016)... June 20, 2016 Securus Technologies, a ... solutions for public safety, investigation, corrections and monitoring ... involved, it has secured the final acceptance by ... for Managed Access Systems (MAS) installed. Furthermore, Securus ... to be installed by October, 2016. MAS distinguishes ...
(Date:6/15/2016)... York , June 15, 2016 ... new market report titled "Gesture Recognition Market by Application ... Forecast, 2016 - 2024". According to the report, the  ... 11.60 billion in 2015 and is estimated to ... USD 48.56 billion by 2024.  Increasing ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... NEW YORK , June, 23, 2016  The ... students to envision new ways to harness living systems ... of Modern Art (MoMA) in New York ... more than 130 participating students, showcased projects at MoMA,s ... included Paola Antonelli , MoMA,s senior curator of ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample tracking software company, ... Crime Laboratory, has joined STACS DNA as a Field Application Specialist. , “I ... President and COO of STACS DNA. “In further expanding our capacity as a scientific ...
(Date:6/23/2016)... NEWPORT BEACH, Calif. , June 23, 2016 /PRNewswire/ ... offering new biological discoveries to the medical community, has ... and co-founder Matthew Nunez . "We ... provide us with the capital we need to meet ... funding will essentially provide us the runway to complete ...
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the only free validated ... will showcase its product’s latest features from June 26 to June 30, 2016 ... on Disrupting Clinical Trials in The Cloud during the conference. DIA (Drug ...
Breaking Biology Technology: