Navigation Links
Presence of certain antibodies signals healthier teeth and gums

ANN ARBOR, Mich.---Antibodies present in people with good oral health could become the first tool for dental professionals to assess a patient's probable response to periodontal disease treatments, say researchers at the University of Michigan.

The antibody is to a protein called HtpG, the bug that makes it is Porphyromonas gingivalis, an important pathogen in periodontal disease. The antibody also has potential as a vaccine candidate, according to Charles Shelburne, assistant research scientist at the U-M School of Dentistry.

Researchers discovered that the HtpG antibodies were present in much lower amounts in people with periodontal disease, and in much higher concentrations in those with healthier teeth and gums. Typically, antibodies are elevated in people with disease, because they help fight the disease.

"What has been seen in periodontal disease over the last 30-40 years is that patients with periodontal disease have higher levels of antibodies to the bacteria associated with periodontal disease, but what we know is that those antibodies aren't usually protective," said Dennis Lopatin, principal investigator and senior associate dean of the School of Dentistry. "It's like being vaccinated against the wrong strain of the flu. The healthy patient makes high levels of the antibodies but to the right part of the bug."

Not only were the HtpG antibodies present in higher amounts in people with healthier gums, those patients with the antibodies responded better to periodontal treatment, the researchers say.

"We're in a position now where we have a potential tool that gives insight as to how the patient will respond to treatment," Lopatin said. "In the United States we spend $8 billion to $12 billion a year caring for people with serious periodontal disease. From a public health standpoint, it's very important to identify those people who not only need therapy but will actually respond to a specific type of therapy."

In the long run, this could lead to early interventional therapy to prevent periodontal disease from advancing, or even starting, he says.

The other part of the question is why people with periodontal disease don't make a good immune response to HtpG, and this could connect back to current thinking that oral health influences general health.

"We want to understand how unique this mechanism is in other types of chronic infections," Lopatin said. "We'd like to think it's not a mechanism unique to just this pathogen, if it is a more common mechanism, it makes it even more interesting."


Contact: Laura Bailey
University of Michigan

Related biology news :

1. Presence of gene mutation helps guide thyroid cancer treatment
2. EPFL Research Day 2008, in the presence of Al Gore
3. Uncertainty drives the evolution of cooperative breeding in birds
4. Bilberry extract -- can it help prevent certain cancers?
5. Certain diseases, birth defects may be linked to failure of protein recycling system
6. Managing uncertainty important in ecological balance: ASU researcher
7. Can certain metals repel sharks from fishing gear?
8. Synthetic molecules may be less expensive alternative to therapeutic antibodies, researchers find
9. Cell response to stress signals predicts tumors in women with common pre-breast cancer
10. Surprise in the organic orchard -- a healthier worm in the apple
11. Alternative food networks connect ethical producers and consumers and can lead to healthier eating
Post Your Comments:
(Date:11/17/2015)... , November 17, 2015 Paris ...   --> Paris from 17 th ... DERMALOG, the biometrics innovation leader, has invented the first combined ... on the same scanning surface. Until now two different scanners ... one scanner can capture both on the same surface. ...
(Date:11/16/2015)... SAN JOSE, Calif. , Nov 16, 2015 ... leading developer of human interface solutions, today announced ... new Synaptics TouchView ™ touch controller and ... the architectural revolution of smartphones. These new TDDI ... and include TD4100 (HD resolution), TD4302 (WQHD resolution), ...
(Date:11/11/2015)... 2015   MedNet Solutions , an innovative SaaS-based eClinical ... is pleased to announce that it will be a Sponsor ... event, to be held November 17-19 in Hamburg ... demonstrations of iMedNet , MedNet,s easy-to-use, proven ... has been able to deliver time and cost savings ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... -- --> --> ... Market by Product & Services (Primer, Probe, Custom Oligos, ... End-User (Research, Pharmaceutical & Biotech, Diagnostic Labs) - Global ... expected to reach USD 1,918.6 Million by 2020 from ... 10.1% during the forecast period. Browse 183 ...
(Date:11/24/2015)... ... 24, 2015 , ... The Academy of Model Aeronautics (AMA), led by its ... as Multirotor Grand Prix, to represent the First–Person View (FPV) racing community. , FPV ... embraced this type of racing and several new model aviation pilots have joined the ...
(Date:11/24/2015)... York , November 24, 2015 ... a recent market research report released by Transparency Market ... to expand at a CAGR of 17.5% during the ... Prenatal Testing Market - Global Industry Analysis, Size, Volume, ... the global non-invasive prenatal testing market to reach a ...
(Date:11/24/2015)... , Nov. 24, 2015 /PRNewswire/ - Aeterna Zentaris ... today that the remaining 11,000 post-share consolidation (or ... Warrants (the "Series B Warrants") subject to the ... on November 23, 2015, which will result in ... giving effect to the issuance of such shares, ...
Breaking Biology Technology: