Navigation Links
Prescription drug could boost effects of vaccines for HIV and other diseases
Date:5/5/2010

A prescription drug already approved to treat genital warts and skin cancer may have a new use in boosting the effectiveness of future vaccines for bacterial and viral diseases, such as hepatitis C and HIV (the AIDS virus). These findings appear in ACS' Molecular Pharmaceutics, a bi-monthly journal.

John Pesce and colleagues at the Naval Medical Research Center and UC-Berkeley note that vaccines prepared from weakened or inactivated viruses or bacteria have had enormous success in preventing polio, influenza, and other diseases. However, vaccines containing living or weakened viruses cannot be used for HIV, hepatitis C, and other devastating diseases due to safety concerns. Scientists are instead trying to develop a new generation of vaccines, made with DNA or proteins from infectious agents that can prevent illness without carrying a risk of causing the diseases. These vaccines will be weaker than conventional vaccines and require a new generation of "adjuvants," ingredients that boost a vaccine's immunogenicity.

The report identifies a promising candidate in the form of imiquimod, an immune-boosting drug already in general use. The scientists coated imiquimod with dextran-based microparticles in hopes of increasing the efficiency of cellular uptake by cells associated with immune response initiation. Sure enough, the coated drug significantly boosted levels of inflammatory cytokines in laboratory cultures of immune cells from mice. The findings have "broad significance" and open the door to more extensive testing of the approach, they indicate.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert  

Page: 1

Related biology news :

1. Fancier fakes: Makers of bogus prescription drugs pose new challenges
2. Some prescription meds can harm fetus
3. MEDNET Launches MedSafe to Prevent Teenage Prescription Drug Abuse
4. MEDNET Launches MedSafe to Prevent Teenage Prescription Drug Abuse
5. Physical activity and health: Finding the right prescription
6. Trends in prescription medication sharing among reproductive-aged women
7. Roots meshed in waste materials could clean dirty water
8. Bionic coating could help ships to economize on fuel
9. Glaucomas unique protein expression could enhance diagnosis and treatment
10. Ben-Gurion U researchers isolate microalgal strain that could reduce cholesterol
11. Olive oil could guard against developing ulcerative colitis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Prescription drug could boost effects of vaccines for HIV and other diseases
(Date:7/28/2014)... of Medicine have pinpointed a mechanism in part of the ... blood, linking it to both type 1 and type 2 ... of Proceedings of the National Academies of Sciences . ... located in a part of the hypothalamus known as the ... that control glucose levels in the blood," said lead author ...
(Date:7/28/2014)... the top 10 U.S. cities that have seen an ... as frequent road closures, overwhelmed storm drains and compromised ... NOAA technical report. , This nuisance flooding, caused by ... coasts, between 300 and 925 percent since the 1960s. ... Frequency Changes around the United States, also finds Annapolis ...
(Date:7/28/2014)... has identified areas of the Earth that are high ... , Europe is particularly vulnerable, as it has the ... cent, of any continent in ,refugia, areas of ... conditions remain relatively constant during times of great environmental ... mostly in Scandinavia and Scotland. , The biggest ...
Breaking Biology News(10 mins):Glucose 'control switch' in the brain key to both types of diabetes 2NOAA: 'Nuisance flooding' an increasing problem as coastal sea levels rise 2NOAA: 'Nuisance flooding' an increasing problem as coastal sea levels rise 3Study finds Europe's habitat and wildlife is vulnerable to climate change 2
... CHAPEL HILL, N.C. -- There has been controversy about ... about whether enough time has elapsed for life to have ... the University of North Carolina at Chapel Hill investigating the ... the time required for evolution on a warm earth is ...
... OH, December 2, 2010 -- Managing diabetes in a child ... Buying essential medical supplies, such as needles and testing strips, ... new study soon to be published in The Journal ... the financial burden of diabetes management increases a child,s risk ...
... December 1, 2010 The versatile organism Lactococcus ... into cheese, may also be valuable in the understanding ... biofuels. New research from Concordia University, published ... the bacterium can be engineered to transform plant material ...
Cached Biology News:Heat helped hasten life's beginnings 2New study calls for greater awareness of food supply for children with diabetes 2
(Date:7/29/2014)... Tenn. (PRWEB) July 29, 2014 ... in biomass feedstock supply innovation and supply chain ... proprietary feedstock management systems, Energy Grange™ and Supply ... of R&D and in-the-field testing aimed at consolidating ... offering benefits to landowners, farmers and feedstock end ...
(Date:7/29/2014)... 29, 2014 Quorum Review IRB, ... been awarded accreditation by the International Association ... Lean Six Sigma Deployment Program. The citation recognizes ... performance. , Quorum’s Lean Six Sigma program was ... Program designation. The designation is a public statement ...
(Date:7/29/2014)... 29, 2014 The first product launch ... generation approach to robotics. What sets Droidles completely apart ... technology that allows them to communicate, share code with ... the internet. , “The invention is the system,” said ... Droidles a life of their own, both physically and ...
(Date:7/29/2014)... Jason Wendel – recipient of a Regional Top Doctor Award ... Plastic Surgeon Specialists for Nashville, TN – has released a ... a Hydration Booster, Retexturing Night Crème, and Anti-aging C Complex, ... more radiant appearance while protecting them from the sun’s harmful ... at Dr. J. J. Wendel Plastic Surgery, we have developed ...
Breaking Biology Technology:Genera Energy Introduces Proprietary Feedstock Management Systems 2Genera Energy Introduces Proprietary Feedstock Management Systems 3Genera Energy Introduces Proprietary Feedstock Management Systems 4Quorum Review IRB Accredited by IASSC for Lean Six Sigma Deployment Program 2Quorum Review IRB Accredited by IASSC for Lean Six Sigma Deployment Program 3Droidles, the Social Network of Robots and Open Source Platform for the Internet of Things, Launches for Crowd Funding on IndieGoGo.com 2Dr. J. J. Wendel Launches New Line of Skin Care Products 2
... have developed the first functional oxide thin films that ... to an array of new high-power devices and smart ... been able to produce positively charged (p-type) conduction and ... launching a new era in oxide electronics. To ...
... California, San Diego electrical engineers are building a forest of ... without using fossil fuels and harvest it for hydrogen fuel ... said nanowires, which are made from abundant natural materials like ... deliver hydrogen fuel on a mass scale. "This ...
... Eye Research Institute, a subsidiary of Mass. Eye and Ear ... first time that a bacterial pathogen can literally mow down ... and infect a part of the body. Their landmark study, ... , describes how they discovered that an "epidemic" strain ...
Cached Biology Technology:Functional oxide thin films create new field of oxide electronics 2Nanotrees harvest the sun's energy to turn water into hydrogen fuel 2Scientists Discover How a Bacterial Pathogen Breaks Down Barriers to Enter and Infect Cells 2Scientists Discover How a Bacterial Pathogen Breaks Down Barriers to Enter and Infect Cells 3
Sheep polyclonal to Streptomycin ( Abpromise for all tested applications). Antigen: Chemical / Small Molecule: Streptomycin conjugated to BSA....
Rabbit polyclonal to MAL ( Abpromise for all tested applications). entrezGeneID: 4118 SwissProtID: P21145...
Glutamate Receptor 5/1a...
Mouse monoclonal [3G8] to MDMA ( Abpromise for all tested applications)....
Biology Products: