Navigation Links
Prenatal exposure to BPA and DES may increase breast cancer risk
Date:5/28/2010

Exposure in the womb to chemicals like Bisphenol-A (BPA) and Diethylstilbestrol (DES) can increase an offspring's risk of breast cancer, researchers at Yale School of Medicine report in a study published in current issue of Hormones and Cancer, a journal of The Endocrine Society.

BPA, DES and similar compounds are known as endocrine-disrupting chemicals, which are substances in the environment that interfere with the proper functioning of hormones. This disruption results in adverse developmental, reproductive, neurological and immune effects in both humans and wildlife.

BPA is a weak estrogen and DES is a strong estrogen, but both have a profound effect on gene expression in the breast throughout life, according to lead author of the study Hugh S. Taylor, M.D., professor in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale School of Medicine. Taylor and his colleagues treated pregnant mice with BPA or DES and then studied the adult offspring. They found that the mammary glands in these offspring produce higher levels of EZH2, a protein that controls the expression of all genes. Higher EZH2 levels are associated with an increased risk of breast cancer in humans. The team demonstrated a mechanism by which endocrine-disrupting chemicals regulate developmental programming in the breast.

"These results show that all estrogens, even weak ones can alter the development of the breast and place our children at risk," said Taylor, who is also a member of Yale Cancer Center. "We many not be able to see the final effects of these exposures until our children reach the age when breast cancers start to appear."

"The data, coupled with our data on DES and BPA effects on the uterus, clearly demonstrate a lasting effect of prenatal exposure to estrogens on the breast and uterus," Taylor added. "This study generates important safety concerns about exposures to environmental endocrine disruptors such as BPA and suggests a potential need to monitor women exposed to these chemicals for the development of breast lesions as adults."


'/>"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
Source:Eurekalert

Related biology news :

1. Rapid prenatal test for alpha-thalassemia
2. Prenatal health-care providers inconsistent in weight-gain counseling
3. Is prenatal screening for rare diseases like spinal muscular atrophy too costly?
4. Good parenting triumphs over prenatal stress
5. Sex-based prenatal brain differences found
6. How to deliver the news? New advice for doctors diagnosing prenatal Down syndrome
7. Prenatal meth exposure linked to abnormal brain development
8. Microarray analysis improves prenatal diagnosis
9. Low sperm count may be associated with prenatal testosterone excess
10. Moderate prenatal exposure to alcohol and stress in monkeys can cause touch sensitivity
11. Trainor Lab characterizes gene essential for prenatal development of nervous system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/7/2016)...  Syngrafii Inc. and San Antonio Credit Union ... integrating Syngrafii,s patented LongPen™ eSignature "Wet" solution into ... result in greater convenience for SACU members and ... existing document workflow and compliance requirements. ... Highlights: ...
(Date:6/1/2016)... -- Favorable Government Initiatives Coupled With Implementation ... to Boost Global Biometrics System Market Through 2021  ... " Global Biometrics Market By Type, By End ... - 2021", the global biometrics market is projected to ... growing security concerns across various end use sectors such ...
(Date:5/9/2016)... , UAE, May 9, 2016 ... when it comes to expanding freedom for high net ... Even in today,s globally connected world, there is ... conferencing system could ever duplicate sealing your deal with ... obtaining second passports by taking advantage of citizenship via ...
Breaking Biology News(10 mins):
(Date:6/22/2016)... 22, 2016 Cell Applications, Inc. and ... to produce up to one billion human induced ... one week. These high-quality, consistent stem cells enable ... and spend more time doing meaningful, relevant research. ... high-volume manufacturing process that produces affordable, reliable HiPSC ...
(Date:6/22/2016)... ANGELES , June 22, 2016   StockNewsNow.com ... SNNLive Video Interview with Dr. Nader Pourhassan , ... biotechnology company focused on the clinical development and potential ... prevention of HIV infection, according to the company,s website ... recorded on Tuesday, June 7 th , 2016, at ...
(Date:6/22/2016)... ... June 21, 2016 , ... New light-based technologies that facilitate ... tissue — promise to enable both compact, wearable devices for point-of-care diagnostics as well ... the skin. , Recent work and visionary future directions are detailed in a new ...
(Date:6/22/2016)... and ALBANY, N.Y. ... Corporation (Teewinot) and Albany Molecular Research, Inc. (NASDAQ: ... has licensed Teewinot,s technology to produce and sell ... standard. The CBCA analytical standard is manufactured using ... the expression of cannabinoid biosynthetic genes in microorganisms ...
Breaking Biology Technology: