Navigation Links
Premature babies at risk of ill health in later life, research suggests

Young adults who were born prematurely show multiple biological signs of risks to future health, research from Imperial College London has found. The scientists, reporting their findings tomorrow in the journal Pediatric Research, say that the research indicates that urgent work is now needed to monitor preterm babies into adulthood to improve the detection of early signs of disease.

The study of 48 volunteers aged 18-27 found that those who were born at 33 weeks of gestation or less had higher blood pressure, more fat tissue despite having a normal Body Mass Index, and more fat in their muscle and liver. These traits are linked to heart and circulatory disease and type 2 diabetes. The differences in fat around the abdomen were most marked in men.

The number of preterm babies born each year is rising, and in developed countries, around 2 per cent of babies are born before 33 weeks of gestation.

Medical advances mean that a higher proportion of babies born early are surviving: 90 per cent of infants born before 33 weeks will go home. However, a few studies have suggested that the impact of preterm birth persists into adulthood, putting premature babies at risk of ill health in later life. The biological pathways involved are unknown.

"This was only a small study but the differences we found were quite striking," said Professor Neena Modi, the lead investigator in the study from the Department of Medicine at Imperial College London. "The results suggest that we need to monitor the health of premature babies beyond infancy and childhood. Preterm men and women might be at greater risk of cardiovascular and metabolic diseases but if we look out for the warning signs, we can help them to stay healthy with lifestyle interventions, and treatment where appropriate."

Professor Neena Modi and her colleagues used whole body magnetic resonance imaging (MRI) and advanced chemical profiling techniques to investigate what biological differences might be present in young adults who were born prematurely.

They found that even though the preterm subjects did not have a higher Body Mass Index (BMI), they did have more fat tissue around their abdomens and in their muscle and liver.

Nuclear magnetic resonance (NMR) spectroscopy revealed differences in the chemical makeup of their urine, with preterm subjects producing more metabolites associated with inflammation, which is in keeping with the higher blood pressure and greater fat found in the preterm subjects.

The study involved 23 healthy men and women born before 33 weeks and 25 healthy men and women born at full term. The preterm volunteers were recruited with the help of Bliss, a national UK premature and sick baby charity.


Contact: Colin Smith
Imperial College London

Related biology news :

1. Researchers find hormone that predicts premature death in kidney patients
2. Socioeconomic class and smoking linked to premature menopause
3. Premature aging caused by some HIV drugs, study shows
4. Scripps Research scientists create new genetic model of premature aging diseases
5. Major breakthrough in preventing premature birth announced by NIH/WSU
6. Tiny RNA molecules control labor, may be key to blocking premature birth
7. Students design early labor detector to prevent premature births
8. Probiotics help extremely premature infants gain weight
9. Periodic heart rate decelerations in premature infants
10. Prevention is key research goal for premature babies, scientists say
11. Women with endometriosis need special care during pregnancy to avoid risk of premature birth
Post Your Comments:
(Date:11/9/2015)... , Nov. 09, 2015 ... addition of the "Global Law Enforcement ... offering. --> ) has ... Law Enforcement Biometrics Market 2015-2019" report ... and Markets ( ) has announced ...
(Date:11/4/2015)... November 4, 2015 --> ... report published by Transparency Market Research "Home Security Solutions Market ... Forecast 2015 - 2022", the global home security solutions market is ... by 2022. The market is estimated to expand at ... 2015 to 2022. Rising security needs among customers at ...
(Date:10/29/2015)... , Oct. 29, 2015   MedNet Solutions , ... entire spectrum of clinical research, is pleased to announce ... Tech Association (MHTA) as one of only three finalists ... "Software – Small and Growing" category. The Tekne Awards honor ... have shown superior technology innovation and leadership. ...
Breaking Biology News(10 mins):
(Date:11/23/2015)... ... ... Noblis, Inc., a leading provider of science, technology, and strategy services, announced ... (NGA), has joined the Noblis NSP team as President of the organization. , ... the private sector,” said L. Roger Mason, Jr., Ph.D. , Senior VP, National ...
(Date:11/23/2015)... and PISCATAWAY, New Jersey ... Cambridge Crystallographic Data Centre (CCDC) announces the ... Structural Database (CSD) and the CSD-System, now complemented ... worldwide: CSD-Discovery to support the discovery of new ... and CSD-Enterprise, the complete set of the CCDC,s ...
(Date:11/23/2015)... , Nov. 23, 2015  CryoLife, Inc. (NYSE: ... focused on cardiac and vascular surgery, announced today that it ... Jaffray Healthcare Conference on Wednesday, December 2, 2015 at The ... . Pat Mackin , President and Chief ... and Chief Executive Officer. --> A live ...
(Date:11/23/2015)... Nov. 23, 2015  Oxis Biotech, Inc. (OXIS), ... [OTC: OXIS] and [Euronext Paris: OXI.PA] announced today ... Cancer Center received notification from the U.S. Food ... with their planned combination Phase 1/Phase 2 clinical ... to develop and commercialize OXS-1550, a novel therapy ...
Breaking Biology Technology: