Navigation Links
Premature aging caused by some HIV drugs, study shows
Date:6/26/2011

A class of anti-retroviral drugs commonly used to treat HIV, particularly in Africa and low income countries, can cause premature ageing, according to research published today in the journal Nature Genetics. The study shows that the drugs damage DNA in the patient's mitochondria the 'batteries' which power their cells.

The findings may explain why HIV-infected people treated with antiretroviral drugs sometimes show advanced signs of frailty and age-associated diseases such as cardiovascular disease and dementia at an early age.

Nucleoside analogue reverse-transcriptase inhibitors (NRTIs) of which the most well known is Zidovudine, also known as AZT were the first class of drug developed to treat HIV. They were a major breakthrough in the treatment of the disease, greatly extending lifespan and leading the condition to be seen as a chronic, rather than terminal, condition.

In high income countries, such as Europe and North America, the older NRTIs are used less commonly now due to concerns over toxicity and side-effects when taken over a long period of time. However, as they are now off-licence and hence relatively cheap, the drugs have proved to be an important lifeline for people infected with HIV in Africa and low income countries.

Professor Patrick Chinnery, a Wellcome Senior Fellow in Clinical Science from the Institute of Genetic Medicine at Newcastle University, says: "HIV clinics were seeing patients who had otherwise been successfully treated but who showed signs of being much older than their years. This was a real mystery. But colleagues recognised many similarities with patients affected by mitochondrial diseases conditions that affect energy production in our cells and referred them to our clinic."

Mitochondria are the 'batteries' in our cells which provide them with the energy to carry out their functions. During natural human ageing, these mitochondria acquire mutations, though it is unclear
'/>"/>

Contact: Craig Brierley
c.brierley@wellcome.ac.uk
44-207-611-7329
Wellcome Trust
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scripps Research scientists create new genetic model of premature aging diseases
2. Major breakthrough in preventing premature birth announced by NIH/WSU
3. Tiny RNA molecules control labor, may be key to blocking premature birth
4. Students design early labor detector to prevent premature births
5. Probiotics help extremely premature infants gain weight
6. Periodic heart rate decelerations in premature infants
7. Prevention is key research goal for premature babies, scientists say
8. Women with endometriosis need special care during pregnancy to avoid risk of premature birth
9. Pre-pregnancy depressed mood may heighten risk for premature birth
10. A genetic link to premature ejaculation
11. Tufted bacteria cause infection in premature babies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/11/2014)... , Nov. 11, 2014  Forensicon, Inc., a ... is pleased to announce the promotion of Yaniv ... of Digital Forensics. In Schiff,s new role as Director, ... team of digital forensics examiners and provide leadership within ... Photo - http://photos.prnewswire.com/prnh/20141110/157719 Schiff ...
(Date:11/7/2014)... Auguste, associate professor, biomedical engineering, in the Grove ... New York, have identified a molecule that could ... most aggressive forms of breast cancer. , Triple ... rate owing to aggressive proliferation and metastasis and ... Auguste,s team, discovered the overexpression of intercellular adhesion ...
(Date:11/7/2014)... , November 6, 2014 Leading ... for better mobile security revolutionizing online transactions.  Companies in focus ... Holdings Ltd. (NYSE: BABA ), Google Inc. (NASDAQ: ... ), eBay Inc. (NASDAQ: EBAY ) and MasterCard ... NXTD and NXTDW), a biometric authentication company focused on ...
Breaking Biology News(10 mins):Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6
... cultivated for the food sector, are accessible marine resources ... by 7.5% on average every year and have become ... of demand for products based on macroalgae for bioenergy, ... deduced from a study led by the Spanish National ...
... working in diverse settings in the US and beyond ... Biology in Baltimore on Thursday July 25 on what ... difference such integrated management efforts are making, and what ... should be. "Ecosystem-scale restoration efforts, particularly in ...
... Infants who get their first solid food before 4 months ... risk of developing Type 1 diabetes, University of Colorado researchers ... Public Health and the CU School of Medicine,s Barbara Davis ... if the mother is still breast-feeding the baby when solid ...
Cached Biology News:Japan, China and South Korea account for 84 percent of the macroalgae patents 2ICCB symposium to examine ecosystem management 2Infants' food linked to higher, lower Type 1 diabetes risk 2
(Date:11/15/2014)... November 14, 2014 New photonics entrepreneurs ... Startup Challenge 2015 , an opportunity to pitch their ... experts and venture capitalists. The annual competition is held ... Center in San Francisco, running 7-12 February and hosted ... photonics . , Cash prizes, including $10,000 for first ...
(Date:11/15/2014)... Algenol Biofuels will present at CleanEquity Monaco 2015 ... Monaco . Logo - ... invitation-only event hosted by Innovator Capital, the London ... and sponsors include Prince Albert II of ... PR Newswire, the Monte-Carlo SBM, Oceanographic Museum of ...
(Date:11/15/2014)... HAYWARD, Calif., Nov. 14, 2014 Anthera Pharmaceuticals, ... results and operational update for the third quarter ended ... the three months ended September 30, 2014 was $7.0 ... in 2013. The increase in net loss is mainly ... result of continued enrollment progress in both our Phase ...
(Date:11/12/2014)... The “Pen Needles Market by by Needle Length (4mm, ... Hormones, Glucagon-like peptide) & by Type (Standard and Safety) ... studies the major market drivers, threats, opportunities, and challenges. ... figures spread through 185 pages and in-depth TOC on ... Needle Length (4mm, 5mm, 6mm, 8mm, 10mm, and 12mm), ...
Breaking Biology Technology:New Photonics Entrepreneurs Need to Apply Now for SPIE Startup Challenge 2015 2New Photonics Entrepreneurs Need to Apply Now for SPIE Startup Challenge 2015 3Algenol Biofuels Selected to Present at CleanEquity Monaco 2015 2Anthera Pharmaceuticals Reports 2014 Third Quarter Financial Results and Operational Update 2Anthera Pharmaceuticals Reports 2014 Third Quarter Financial Results and Operational Update 3Anthera Pharmaceuticals Reports 2014 Third Quarter Financial Results and Operational Update 4Anthera Pharmaceuticals Reports 2014 Third Quarter Financial Results and Operational Update 5Anthera Pharmaceuticals Reports 2014 Third Quarter Financial Results and Operational Update 6Pen Needles Market worth $2,105 Million by 2019 - New Report by MarketsandMarkets 2Pen Needles Market worth $2,105 Million by 2019 - New Report by MarketsandMarkets 3Pen Needles Market worth $2,105 Million by 2019 - New Report by MarketsandMarkets 4
... LLC , a local company that makes voice software, has ... slip into their characters' roles in computer games or chat. ... a troll, giant, dwarf or dark lord," said Mark Ramirez, ... company's MorphVox software is made to be used with existing ...
... year ago, I wrote a column criticizing an "advice article" ... notices when leaving a company. ( Ready to leave? ... was published both on ePrairie and with the Wisconsin Technology ... Since then, there have been many comments and personal stories ...
... Corporation says its scientists have developed a way ... naturally part of the immune system, are manufactured both ... research. Mirus' new technique, described in the February issue ... immune systems produce the antibodies that are harvested and ...
Cached Biology Technology:Employees debate ethics of giving two weeks' notice 2Employees debate ethics of giving two weeks' notice 3Employees debate ethics of giving two weeks' notice 4Employees debate ethics of giving two weeks' notice 5
... Leptin is a proteohormone with a molecular weight of ... the ob gene and produced by adipocytes [1,2]. ... the regulation of body weight [1-3]. In the ... both men and women [4]. A relationship between ...
Request Info...
... DNA preparations are prepared from customers ... 1mg to multi-gram scales. Small-scale ... preparations are made according to customer ... according to customer needs, and glycerol ...
... can operate as a Voltage Clamp, as ... Clamp in electrophysiology research applications. Performance in ... analog equipment. This amazing instrument is made ... of Digital Signal Processing (DSP) integrated circuit chips. ...
Biology Products: