Navigation Links
Premature aging caused by some HIV drugs, study shows
Date:6/26/2011

A class of anti-retroviral drugs commonly used to treat HIV, particularly in Africa and low income countries, can cause premature ageing, according to research published today in the journal Nature Genetics. The study shows that the drugs damage DNA in the patient's mitochondria the 'batteries' which power their cells.

The findings may explain why HIV-infected people treated with antiretroviral drugs sometimes show advanced signs of frailty and age-associated diseases such as cardiovascular disease and dementia at an early age.

Nucleoside analogue reverse-transcriptase inhibitors (NRTIs) of which the most well known is Zidovudine, also known as AZT were the first class of drug developed to treat HIV. They were a major breakthrough in the treatment of the disease, greatly extending lifespan and leading the condition to be seen as a chronic, rather than terminal, condition.

In high income countries, such as Europe and North America, the older NRTIs are used less commonly now due to concerns over toxicity and side-effects when taken over a long period of time. However, as they are now off-licence and hence relatively cheap, the drugs have proved to be an important lifeline for people infected with HIV in Africa and low income countries.

Professor Patrick Chinnery, a Wellcome Senior Fellow in Clinical Science from the Institute of Genetic Medicine at Newcastle University, says: "HIV clinics were seeing patients who had otherwise been successfully treated but who showed signs of being much older than their years. This was a real mystery. But colleagues recognised many similarities with patients affected by mitochondrial diseases conditions that affect energy production in our cells and referred them to our clinic."

Mitochondria are the 'batteries' in our cells which provide them with the energy to carry out their functions. During natural human ageing, these mitochondria acquire mutations, though it is unclear
'/>"/>

Contact: Craig Brierley
c.brierley@wellcome.ac.uk
44-207-611-7329
Wellcome Trust
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scripps Research scientists create new genetic model of premature aging diseases
2. Major breakthrough in preventing premature birth announced by NIH/WSU
3. Tiny RNA molecules control labor, may be key to blocking premature birth
4. Students design early labor detector to prevent premature births
5. Probiotics help extremely premature infants gain weight
6. Periodic heart rate decelerations in premature infants
7. Prevention is key research goal for premature babies, scientists say
8. Women with endometriosis need special care during pregnancy to avoid risk of premature birth
9. Pre-pregnancy depressed mood may heighten risk for premature birth
10. A genetic link to premature ejaculation
11. Tufted bacteria cause infection in premature babies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... SALEM, N.C. , Dec. 10, 2014  That blood ... for quite a while. Hypertension – the medical term for ... in the early 1800s, and the inflatable cuff that,s used ... That doesn,t, however, mean there,s nothing new about hypertension, its ... some long-held beliefs about the condition and the best ways ...
(Date:12/10/2014)...  Wake Forest Baptist Medical Center today announced plans for ... Medicine. Funding for this $50 million capital project is ... publicly launched next summer. The medical ... series R.J. Reynolds Tobacco Company complex, adjacent to 525@vine ... with plans to be ready to welcome medical students ...
(Date:12/5/2014)... 4, 2014 Increased emphasis on product ... new testing and inspection technologies. The convergence of ... a range of innovative test solutions. This trend ... Y, which is generally more inclined towards communication, ... development strategies of test equipment vendors will cater ...
Breaking Biology News(10 mins):Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4
... programmable "molecular robot" a sub-microscopic molecular machine made ... by 6nm. The robot, a short strand of DNA, ... determining its destination, for example, to turn left or ... which represents a step toward futuristic nanomachines and nanofactories, ...
... comforting tuck-them-in-words "Sleep tight, don,t let the bedbugs ... people as the world experiences a resurgence of an ... and the risk of exposure to potentially toxic materials. ... current edition of Chemical & Engineering News (C&EN), ACS, ...
... The European Society for Clinical and Economic ... International Osteoporosis Foundation (IOF) have announced that Professor ... is to be awarded the first Herbert A. ... researcher whose groundbreaking work contributed to the development ...
Cached Biology News:Inaugural Herbert A. Fleisch ESCEO-IOF Medal is awarded to Professor Gerard Karsenty 2
(Date:12/24/2014)... PharmaBoardroom,s new report, , Healthcare and Life ... free download , digs deep into this vibrant market, speaking ... today. One area where Algeria ... homegrown pharmaceutical manufacturing base, even if the government,s ambitious target ... A cursory comparison with neighboring Morocco ...
(Date:12/24/2014)... Dec. 23, 2014  Rock Creek Pharmaceuticals, Inc., (NASDAQ: ... filed a Clinical Trial Application (CTA) with the ... Agency (MHRA) seeking regulatory approval to initiate clinical trials ... Citrate. Contingent on the Company receiving CTA ... I trial to assess the safety, tolerability and dose ...
(Date:12/22/2014)... Malvern, PA & Brussels (PRWEB) December 22, 2014 ... Education (CfPIE), the global leader of technical training ... Society for Clinical Data Management (SCDM) to ... training and certification programs —providing access to the ... The partnership extends SCDM members with 10% off when ...
(Date:12/22/2014)... , Dec. 22, 2014 /PRNewswire/ - RepliCel Life ... regenerative medicine company focused on the development of autologous ... out of the University of Calgary in conjunction with ... Carolina, which further validates the company,s ongoing clinical research ... effects of pattern baldness. The paper entitled ...
Breaking Biology Technology:PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 3CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 2Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 4Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 5
... Sonic Foundry reported revenue up 86 percent and a narrowed ... presentation hardware and software for business, government and education. , ... $4.4 million. The company still had a $4.2 million net ... , ,All of this is the effect of the firm's ...
... financing of health care in the United States are enough ... About one in seven Americans (15.7 percent) lack health insurance. ... to the latest federal figures, health spending accounts for 15.3 ... trillion in 2003 works out to $5,670 for each American. ...
... New Year and time for pundits everywhere to predict every possibility ... the more I looked at it, the more it became obvious ... share this with a minor tremor of trepidation. I worked in ... with increasing certainty as the "Year of the LAN." ...
Cached Biology Technology:Health care economics make definition of 'cost' problems difficult 2Health care economics make definition of 'cost' problems difficult 3The year of working together (really!) 2The year of working together (really!) 3
MOUSE ANTI SIMIAN VIRUS 5 Immunogen: Simian virus 5...
MOUSE ANTI SIMIAN VIRUS 5:FITC Immunogen: Simian virus 5...
MOUSE ANTI HUMAN MBP (67-74) Immunogen: Human myelin basic protein...
... Purification Kit is designed to purify double-stranded DNA ... synthesis and PCR. The process is simple and ... 3 g can be efficiently purified and concentrated. ... DNA is bound to the Microfilter Cartridge in ...
Biology Products: