Navigation Links
Preimplantation genetic diagnosis may pose neurological risks
Date:7/21/2009

Preimplantation genetic diagnosis (PGD) has helped many couples conceive healthy children and is generally considered a safe practice. However, a new long-term analysis of PGD in mice suggests that this procedure may increase risks of weight gain and memory decline in adulthood.

PGD is used alongside assisted reproduction technologies to ensure couples that may be carriers of genetic disease (e.g. Ashkenazi Jews who have a high incidence of Tay-Sachs among their population) don't pass on defective genes to their children. While PGD is not believed to pose any serious health risks, the procedure does involve manipulating the developing embryo and no rigorous long-term studies have been carried out.

Ran Huo, Qi Zhou and colleagues used a mouse model to examine how a blastomere biopsy, as the key manipulation during the PGD procedure, could affect fetal, neonatal and adult development.

They found that there were no differences in embryo development prior to uterine implantation in the biopsied and control groups, which is consistent with results found in humans. However, following implantation, successful births from biopsied embryos were significantly lower than in controls.

Following birth, the authors tracked many physical and behavioral properties; the two groups of mice were similar in many respects, though mice in the biopsied group on average had higher body weight and poorer memory in maze tests. To get a more detailed picture of these memory defects, the authors performed a proteomic analysis of adult mouse brains; 36 proteins displayed significant differences between biopsied and control groups, 17 of which are closely associated with neurodegenerative disorders like Alzheimers and Down Syndrome.

The authors suggest that the developing nervous system may be sensitive to blastomere biopsy, and that more studies should be performed to address any possible long-term adverse effects of PGD to ensure its safety.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Related biology news :

1. Attitudes towards assisted reproduction and preimplantation genetic diagnosis
2. New research finds possible genetic link to cause of pregnancy loss and disorders
3. Iowa State University researchers develop process for surgical genetic changes
4. LincRNAs serve as genetic air-traffic controllers
5. Genetic factors implicated in survival gap for breast, ovarian or prostate cancer
6. Genetically engineered mice yield clues to knocking out cancer
7. New test can detect both genetic and chromosomal abnormalities in embryos
8. New, less invasive genetic test greatly improves pregnancy rates in older women with poor prognosis
9. T-STAR grant funds genetic studies on shrimp and papaya and endangered cycad rescue
10. Genetic finding could lead to targeted therapy for neuroblastoma
11. New piece found in the puzzle of epigenetics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... 2016   Acuant , the leading ... has partnered with RightCrowd ® to ... Management, Self-Service Kiosks and Continuous Workforce Assurance. ... functional enhancements to existing physical access control ... with an automated ID verification and authentication ...
(Date:6/16/2016)... The global Biometric ... USD 1.83 billion by 2024, according to a ... proliferation and increasing demand in commercial buildings, consumer ... the market growth.      (Logo: ... of advanced multimodal techniques for biometric authentication and ...
(Date:6/7/2016)... , June 7, 2016  Syngrafii Inc. ... a business relationship that includes integrating Syngrafii,s patented ... branch project. This collaboration will result in greater ... the credit union, while maintaining existing document workflow ... http://photos.prnewswire.com/prnh/20160606/375871LOGO ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf ... join the faculty of the University of North Carolina Kenan-Flagler Business School ... and entrepreneurship at UNC Kenan-Flagler, with a focus on the school’s international efforts, ...
(Date:6/24/2016)... ... ... While the majority of commercial spectrophotometers and fluorometers use the z-dimension of ... higher end machines that use the more unconventional z-dimension of 20mm. Z-dimension ... of the cuvette holder. , FireflySci has developed several Agilent flow cell product ...
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT has ... Ontario biotechnology company, Propellon Therapeutics Inc. ... and commercialization of a portfolio of first-in-class WDR5 ... targets such as WDR5 represent an exciting class ... in precision medicine for cancer patients. Substantial advances ...
(Date:6/23/2016)... 23, 2016  The Biodesign Challenge (BDC), a university ... to harness living systems and biotechnology, announced its winning ... New York City . ... showcased projects at MoMA,s Celeste Bartos Theater during the ... MoMA,s senior curator of architecture and design, and ...
Breaking Biology Technology: