Navigation Links
Preimplantation genetic diagnosis may pose neurological risks
Date:7/21/2009

Preimplantation genetic diagnosis (PGD) has helped many couples conceive healthy children and is generally considered a safe practice. However, a new long-term analysis of PGD in mice suggests that this procedure may increase risks of weight gain and memory decline in adulthood.

PGD is used alongside assisted reproduction technologies to ensure couples that may be carriers of genetic disease (e.g. Ashkenazi Jews who have a high incidence of Tay-Sachs among their population) don't pass on defective genes to their children. While PGD is not believed to pose any serious health risks, the procedure does involve manipulating the developing embryo and no rigorous long-term studies have been carried out.

Ran Huo, Qi Zhou and colleagues used a mouse model to examine how a blastomere biopsy, as the key manipulation during the PGD procedure, could affect fetal, neonatal and adult development.

They found that there were no differences in embryo development prior to uterine implantation in the biopsied and control groups, which is consistent with results found in humans. However, following implantation, successful births from biopsied embryos were significantly lower than in controls.

Following birth, the authors tracked many physical and behavioral properties; the two groups of mice were similar in many respects, though mice in the biopsied group on average had higher body weight and poorer memory in maze tests. To get a more detailed picture of these memory defects, the authors performed a proteomic analysis of adult mouse brains; 36 proteins displayed significant differences between biopsied and control groups, 17 of which are closely associated with neurodegenerative disorders like Alzheimers and Down Syndrome.

The authors suggest that the developing nervous system may be sensitive to blastomere biopsy, and that more studies should be performed to address any possible long-term adverse effects of PGD to ensure its safety.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Related biology news :

1. Attitudes towards assisted reproduction and preimplantation genetic diagnosis
2. New research finds possible genetic link to cause of pregnancy loss and disorders
3. Iowa State University researchers develop process for surgical genetic changes
4. LincRNAs serve as genetic air-traffic controllers
5. Genetic factors implicated in survival gap for breast, ovarian or prostate cancer
6. Genetically engineered mice yield clues to knocking out cancer
7. New test can detect both genetic and chromosomal abnormalities in embryos
8. New, less invasive genetic test greatly improves pregnancy rates in older women with poor prognosis
9. T-STAR grant funds genetic studies on shrimp and papaya and endangered cycad rescue
10. Genetic finding could lead to targeted therapy for neuroblastoma
11. New piece found in the puzzle of epigenetics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... April 11, 2017 NXT-ID, Inc. (NASDAQ: ... company, announces the appointment of independent Directors Mr. Robin ... its Board of Directors, furthering the company,s corporate governance and ... Gino Pereira ... look forward to their guidance and benefiting from their considerable ...
(Date:4/5/2017)... 4, 2017 KEY FINDINGS The ... at a CAGR of 25.76% during the forecast period ... primary factor for the growth of the stem cell ... MARKET INSIGHTS The global stem cell market ... and geography. The stem cell market of the product ...
(Date:3/30/2017)... HONG KONG , March 30, 2017 ... developed a system for three-dimensional (3D) fingerprint identification by adopting ground ... technology into a new realm of speed and accuracy for use ... applications at an affordable cost. ... ...
Breaking Biology News(10 mins):
(Date:6/19/2017)... , ... June 19, 2017 , ... ... for clinical development reported today that it is launching two new additions of ... will be demonstrating new capabilities at the DIA 2017 Annual Meeting in Chicago, ...
(Date:6/16/2017)... ... 2017 , ... Cognition Corporation , a software company ... of its “From the Helm” Webinar Series. , The next two free ... design control exercises. Led by David Cronin, Cognition’s CEO, the half-hour public webinars ...
(Date:6/15/2017)... ... 2017 , ... New resistant soybean and cotton cropping systems ... amaranth and other broadleaf weeds resistant to glyphosate. But scientists with the Weed ... known to drift and to cause harm to sensitive, off-target broadleaf plants. , ...
(Date:6/15/2017)... (PRWEB) , ... June 15, 2017 , ... ... Saranas, a promising new medical device startup. Dan Parsley, angelMD’s SVP of Corporate ... angelMD members, and this angelMD syndicate is part of Saranas’ recently announced $4 ...
Breaking Biology Technology: