Navigation Links
Preimplantation genetic diagnosis may pose neurological risks
Date:7/21/2009

Preimplantation genetic diagnosis (PGD) has helped many couples conceive healthy children and is generally considered a safe practice. However, a new long-term analysis of PGD in mice suggests that this procedure may increase risks of weight gain and memory decline in adulthood.

PGD is used alongside assisted reproduction technologies to ensure couples that may be carriers of genetic disease (e.g. Ashkenazi Jews who have a high incidence of Tay-Sachs among their population) don't pass on defective genes to their children. While PGD is not believed to pose any serious health risks, the procedure does involve manipulating the developing embryo and no rigorous long-term studies have been carried out.

Ran Huo, Qi Zhou and colleagues used a mouse model to examine how a blastomere biopsy, as the key manipulation during the PGD procedure, could affect fetal, neonatal and adult development.

They found that there were no differences in embryo development prior to uterine implantation in the biopsied and control groups, which is consistent with results found in humans. However, following implantation, successful births from biopsied embryos were significantly lower than in controls.

Following birth, the authors tracked many physical and behavioral properties; the two groups of mice were similar in many respects, though mice in the biopsied group on average had higher body weight and poorer memory in maze tests. To get a more detailed picture of these memory defects, the authors performed a proteomic analysis of adult mouse brains; 36 proteins displayed significant differences between biopsied and control groups, 17 of which are closely associated with neurodegenerative disorders like Alzheimers and Down Syndrome.

The authors suggest that the developing nervous system may be sensitive to blastomere biopsy, and that more studies should be performed to address any possible long-term adverse effects of PGD to ensure its sa
'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Attitudes towards assisted reproduction and preimplantation genetic diagnosis
2. New research finds possible genetic link to cause of pregnancy loss and disorders
3. Iowa State University researchers develop process for surgical genetic changes
4. LincRNAs serve as genetic air-traffic controllers
5. Genetic factors implicated in survival gap for breast, ovarian or prostate cancer
6. Genetically engineered mice yield clues to knocking out cancer
7. New test can detect both genetic and chromosomal abnormalities in embryos
8. New, less invasive genetic test greatly improves pregnancy rates in older women with poor prognosis
9. T-STAR grant funds genetic studies on shrimp and papaya and endangered cycad rescue
10. Genetic finding could lead to targeted therapy for neuroblastoma
11. New piece found in the puzzle of epigenetics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... scientists were instrumental in the creation of the Santa ... classify the fire threat potential of the powerful, hot, ... into an inferno. The index was introduced Sept. 17 ... and San Diego Gas and Electric. , The index ... that will be used to help fire agencies and ...
(Date:9/17/2014)... (Sept. 17, 2014) A rare genetic disorder known as ... a recent joint investigation by researchers at San Diego ... In addition to suggesting better treatment options for people ... into the genetic underpinnings of autism., Jacobsen syndrome affects ... Institutes of Health. It occurs in a person when ...
(Date:9/17/2014)... IMIM (Hospital del Mar Medical Research Institute) and at ... a study in eLife showing that RNA ... evolution of new proteins, some of which could have ... proteins from the instructions found in an RNA molecule. ... containing information for the synthesis of proteins, meaning it ...
Breaking Biology News(10 mins):UCLA scientists play key role in developing new Santa Ana Wildfire Threat Index 2A link between Jacobsen syndrome and autism 2Parts of genome without a known function may play a key role in the birth of new proteins 2
... video games can help to train the brain to become ... Queen Mary University of London and University College London (UCL). ... flexibility, described as a person,s ability to adapt and switch ... time to solve problems. Two groups of volunteers were ...
... drug and dietary supplement manufacturers are updating the tests used ... impurities, and the stringent new requirements, instruments and costs are ... of Chemical & Engineering News . C&EN is the ... scientific society. Ann Thayer, C&EN senior correspondent, explains that ...
... role in how people,s taste receptors send signals, leading ... Penn State food scientists. These varied, genetically influenced responses ... a range of artificial sweeteners to accommodate different consumer ... respond to tastes of foods," said John Hayes, assistant ...
Cached Biology News:Playing video games can boost brain power 2Multiple genes manage how people taste sweeteners 2
(Date:9/17/2014)... , Sept. 17, 2014 A ... accelerated partial breast irradiation (APBI) via interstitial brachytherapy ... with positive lymph nodes could be suitable to ... Oncology (ASTRO) guidelines place these patients in the ... at the 2014 ASTRO meeting, Beaumont Health System,s ...
(Date:9/17/2014)... COLUMBIA, Md. (PRWEB) September 17, 2014 ... Nexera-e Comprehensive Two-Dimensional Liquid Chromatograph (2D-LC), which ... most complex sample matrices. The system provides ... of sample analytes, which is beneficial to ... food extracts, and natural products. , Comprehensive ...
(Date:9/17/2014)... 17, 2014 Immunomic Therapeutics, Inc. announced ... (SBIR) grant to support the continued preclinical development of ... with approximately $255,000 over one year to conduct vaccine ... food allergy, affect over one million Americans and are ... Tree nut exposure is also a risk for peanut ...
(Date:9/17/2014)... /PRNewswire/ - SQI Diagnostics Inc. (TSX-V: SQD) (OTCQX: SQIDF), ... technologies and products for advanced microarray diagnostics, today announced ... in the United States on ... on September 17, 2014 on the OTCQX under the ... the TSX Venture Exchange under its existing symbol SQD. ...
Breaking Biology Technology:Partial Breast Irradiation With Interstitial Brachytherapy Appears Appropriate For Women Previously Considered Unsuitable 2Partial Breast Irradiation With Interstitial Brachytherapy Appears Appropriate For Women Previously Considered Unsuitable 3Partial Breast Irradiation With Interstitial Brachytherapy Appears Appropriate For Women Previously Considered Unsuitable 4Shimadzu’s New Nexera-e Two Dimensional Comprehensive Liquid Chromatograph Empowers Laboratories to Separate Even the Most Complex Mixtures 2Immunomic Therapeutics Awarded SBIR Grant to Develop Multi-Nut Allergy Immunotherapy 2Immunomic Therapeutics Awarded SBIR Grant to Develop Multi-Nut Allergy Immunotherapy 3SQI Diagnostics to begin Trading on the OTCQX Marketplace in the United States 2SQI Diagnostics to begin Trading on the OTCQX Marketplace in the United States 3
... Practical Implementation of ... Intra-Operative Imaging, NUREMBERG, Germany, October 13 ... at the beginning of,the year, Ziehm Imaging, provider of mobile x-ray ... provides,training in line with international standards, in order to keep its,partners ...
... SYDNEY, Australia, Oct. 13 /Xinhua-PRNewswire-FirstCall/ -- Pharmaxis,Ltd (AXS: ... Quarterly,Report to Shareholders on the afternoon of Wednesday ... teleconference the following morning to,review the quarter and ... on Thursday 16th October at 8.30am (Sydney),(Wednesday 15th ...
... Oct. 10 Cell Therapeutics, Inc.,(CTI) (Nasdaq and ... to,request a hearing with the NASDAQ Listing Qualifications ... NASDAQ Marketplace Rule 4450(b)(1)(A),which requires a minimum market ... a Staff Determination Letter from The NASDAQ Stock ...
Cached Biology Technology:Ziehm Imaging Extends its Training Offer 2Ziehm Imaging Extends its Training Offer 3Ziehm Imaging Extends its Training Offer 4Cell Therapeutics to Request a Hearing With NASDAQ Following Receipt of Staff Determination Letter 2Cell Therapeutics to Request a Hearing With NASDAQ Following Receipt of Staff Determination Letter 3
Agarose, pulse field, 250 g. Nuclease-free.Gel point (1.5%): 36 1.5 C, EEO (-mr): 1800 g/cm2. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
Agarose, pulse field, 100 g. Nuclease-free.Gel point (1.5%): 36 1.5 C, EEO (-mr): 1800 g/cm2. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
Request Info...
Lentigen's manufacturing platform is sufficiently versatile for use in the manufacture of any HIV-based Lentiviral vector. Lentigen will manufacture your LV of choice to the highest possible titer a...
Biology Products: