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Pregnant women with high celiac disease antibodies are at risk for low birth weight babies
Date:4/29/2013

y pregnancy or whether it reflects a subclinical state of celiac disease that needs follow-up," added Jong.

Further helping to identify the connection between anti-tTG levels and celiac disease, a study in Clinical Gastroenterology and Hepatology reconfirms the recent European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) guidelines, which recognize that the likelihood for celiac disease increases with increasing antibody concentration.

Research from University Hospitals Leuven, Belgium, stresses the importance of also monitoring for relevant symptoms, such as weight loss, failure to thrive, anemia, iron deficiency or fatigue, when diagnosing patients, and notes that physicians should not rely solely on anti-tTG testing to make a diagnosis.

The study found that there is a 50 to 75 percent chance that persons without symptoms, but with anti-tTG levels more than 10 times the cutoff value, as defined in the ESPGHAN guidelines, will have celiac disease. The probability that a patient has celiac disease rises to 95 percent or higher when, in addition to high anti-tTG levels, the patient expresses complaints that can be associated with celiac disease.


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Contact: Rachel Steigerwald
media@gastro.org
301-272-1603
American Gastroenterological Association
Source:Eurekalert

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