Navigation Links
Pregnant patients lose out in breast cancer treatment; a new approach is needed
Date:4/16/2008

Berlin, Germany: Pregnant breast cancer patients can be treated as closely as possible to existing guidelines for non-pregnant patients, with few ill effects, a scientist told the 6th European Breast Cancer Conference (EBCC-6) today (Wednesday 16 April).

Dr. Sibylle Loibl, Assistant Professor in Obstetrics and Gynaecology at University of Frankfurt, Germany, and a member of the German Breast Group, said that until now, evidence upon which decisions on treatment for pregnant patients could be made was limited, and that a cautious approach by doctors meant that many women did not get the best treatment for their cancer. We realised that there are hardly any data on this subject, she said, and therefore set out to collect information from patients in Germany and throughout Europe.

The German Breast Group launched a data-collection exercise in 2003. Information on 122 pregnant patients diagnosed with breast cancer between April 2003 and December 2007 was analysed for a number of factors foetal outcome four weeks after delivery, maternal outcome of pregnancy, stage and biological characteristics of the breast cancer, breast cancer therapy, sensitivity and specificity of diagnostic procedures, outcome of the child five years later, and outcome of the breast cancer five years after diagnosis.

The median gestational age at the time of diagnosis was 21 weeks, and the median age of the women 33 years. Some patients chose not to continue the pregnancy on learning of their diagnosis, but of those who did, 33.3% received surgery only, 43.2% were treated by surgery and chemotherapy, 5.4% by chemotherapy alone, and 2.7% had no treatment at all. The median time for delivery was 36 weeks, slightly earlier than that which is normal in healthy women. Although there were some health problems among the newborn babies, they were generally minor, and the foetal outcome in babies whose mothers received chemotherapy was not different to those whose mothers did not.

We are still analysing some of the data, said Dr. Loibl, but in terms of our primary endpoint, foetal outcome four weeks after delivery, we are able to say that this shows that pregnant patients can benefit from the same breast cancer treatment that is given to non-pregnant women, and that this should be done in standardised multidisciplinary teams. Later this year we hope to have collected 200 patients in the dataset. This will be the largest ever data collection concerning breast cancer during pregnancy, and we intend to follow up these women and their children over a long period of time to produce further information. We are grateful to all collaborating doctors in Germany and neighbouring countries who are helping us to gain data on this important issue.

The training of doctors to deal with pregnant breast cancer patients and the centralisation of information on such patients will help raise awareness of the issues involved, says Dr. Loibl. We hope that in the future we may be able to conduct trials in such patients and gain further important data. Treatments are improving all the time, and new drugs are on the horizon waiting to be implemented into the adjuvant therapy of breast cancer.

However, in order to conduct trials in such a group there are considerable difficulties, said Dr. Loibl. Insurance for a study in pregnant patients is almost impossible to get, and, additionally, because the group to be studied will be small, it would be necessary to enrol patients from several hundred clinics in order to achieve a statistically valid result. We need some kind of fast-tracking to be able to get such a trial underway, but, in the meantime, pregnant patients should not lose out just because the data on their treatment are limited, she said.


'/>"/>

Contact: Mary Rice
mary@mrcommunication.org
ECCO-the European CanCer Organisation
Source:Eurekalert

Related biology news :

1. Humans unknowing midwives for pregnant moose
2. Pregnant women at risk for unnecessary operations due to misdiagnosis of appendicitis
3. Abnormal fat metabolism underlies heart problems in diabetic patients
4. A new radiation therapy treatment developed for head and neck cancer patients
5. Device helps patients survive, regain function til transplant
6. Diet support helps chronic kidney patients
7. Cystic fibrosis patients may breathe easier, thanks to bioengineered antimicrobials
8. Doctors learn to control their own brains pain responses to better treat patients
9. Jefferson urologists studying regenerated neo-bladder to help spinal cord injury patients
10. Israeli scientists identify: Genes that affect responses of multiple sclerosis patients to copaxone
11. New class of drug offers hope to treatment-resistant AIDS patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/4/2017)... , Oct. 4, 2017  GCE Solutions, a global clinical ... data and document anonymization solution on October 4, 2017. Shadow is ... field to comply with policy 0070 of the European Medicines Agency ... data. ... GCE Solutions ...
(Date:8/15/2017)... 2017   ivWatch LLC , a medical device company focused ... announced receipt of its ISO 13485 Certification, the global standard for ... for Standardization (ISO┬«). ... 400 Continuous Monitoring device for the early detection of IV infiltrations. ... "This is an important milestone for ivWatch, ...
(Date:6/30/2017)... 2017 Today, American Trucking Associations announced ... face and eye tracking software, became the newest ... "Artificial intelligence and advanced sensing ... a driver,s attentiveness levels while on the road.  ... detect fatigue and prevent potential accidents, which could ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , ... of Cancer Research, London (ICR) and ... with SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple ... as MUK nine . The University of ... is partly funded by Myeloma UK, and ICR will perform ...
(Date:10/10/2017)... ... October 10, 2017 , ... San Diego-based team building and cooking events company, ... today. The bold new look is part of a transformation to increase awareness, ... significant growth period. , It will also expand its service offering from its signature ...
(Date:10/10/2017)... Parks Associates announced today that Tom Kerber , Director ... , October 11 in Scottsdale, Arizona . Kerber will ... safety and security products impact the competitive landscape. ... Parks Associates: Smart Home Devices: Main Purchase Driver ... "The residential security market has experienced continued growth, and the introduction of ...
(Date:10/9/2017)... , Oct. 9, 2017  BioTech Holdings announced ... by which its ProCell stem cell therapy prevents ... ischemia.  The Company, demonstrated that treatment with ProCell ... limbs saved as compared to standard bone marrow ... HGF resulted in reduction of therapeutic effect.  ...
Breaking Biology Technology: