Navigation Links
Preferable treatment for MS found in allogenic bone marrow stem cells
Date:12/18/2013

Putnam Valley, NY. (Dec. 18, 2013) Multiple sclerosis (MS), an inflammatory autoimmune disease affecting more than one million people worldwide, is caused by an immune reaction to myelin proteins, the proteins that help form the myelin insulating substance around nerves. Demyelination and MS are a consequence of this immune reaction. Bone marrow mesenchymal stem cells (MSCs) have been considered as an important source for cell therapy for autoimmune diseases such as MS because of their immunosuppressive properties.

Now, a research team in Brazil has compared MSCs isolated from MS patients and from healthy donors to determine if the MSCs from MS patients are normal or defective. The study will be published in a future issue of Cell Transplantation but is currently freely available on-line as an unedited early e-pub at: http://www.ingentaconnect.com/content/cog/ct/pre-prints/content-ct1131.

"The ability of MSCs to modulate the immune response suggests a possible role of these cells in tolerance induction in patients with autoimmune diseases, and also supports the rationale for MSC application in the treatment of MS," said study corresponding author Dr. Gislane Lelis Vilela de Oliveira of the Center for Cell-Based Research at the University of Sao Paulo. "We found that MS patient-derived MSCs present higher senescence, or biological aging, and decreased expression of important immune system markers as well as a different transcriptional profile when compared to their healthy counterparts."

The researchers suggested that further clinical studies should be conducted using transplanted allogenic (other-donated) MSCs derived from healthy donors to determine if the MSCs have a therapeutic effect over transplanted autologous (self-donated) MSCs from patients.

"Several reports have shown that bone marrow-derived MSCs are able to modulate innate and adaptive immunity cell responses and induce tolerance, thus supporting the rationale for their application in treating autoimmune diseases, " said the researchers.

They also noted that studies have shown that transplanted MSCs migrate to demyelinated areas as well as induce generation and expansion of regulatory T cells, important in immunity.

"We found that the transcriptional profile of patient MSCs after transplantation was closer to that of their pre-transplant MSC samples than those from their healthy counterparts, suggesting that treatment with patient self-donated MSCs does not reverse the alterations we observed in MSCs from MS patients," they concluded.

The researchers further noted that their results might not be representative of "typical" MS patients because their study included only patients who were refractory to conventional treatments.

"This study highlights one of the potential problems with autologous stem cell transplants" said Dr. Paul R. Sanberg, distinguished professor at the Center of Excellence for Aging and Brain Repair, Morsani College of Medicine, University of South Florida, Tampa, FL. "Autologous cells are frequently affected by the disease etiology thus reducing their ability to be effective, meaning that allogenic transplants maybe preferable to maximize their potential benefit if other concerns such as rejection can be overcome."


'/>"/>

Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related biology news :

1. Packaging insulin into a pill-friendly form for diabetes treatment
2. Physicians awarded $4 million to study effects of fertility treatments and obstetric care
3. U-M tinnitus discovery opens door to possible new treatment avenues
4. Wayne State discovers potential treatment for skin and corneal wound healing in diabetics
5. New gene therapy proves promising as hemophilia treatment
6. Picturing pain could help unlock its mysteries and lead to better treatments
7. Scientists identified T372R mutation as potential target for diagnosis and treatment of insulinoma
8. Targeted treatment can significantly reduce relapse in children with AML leukemia
9. Columbias 2013 Horwitz Prize awarded for discoveries that could lead to new Alzheimers treatments
10. MassBiologics receives orphan drug status from FDA for hepatitis C treatment
11. New compound for slowing the aging process can lead to novel treatments for brain diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/6/2017)... , April 6, 2017 Forecasts ... ANPR, Document Readers, by End-Use (Transportation & Logistics, Government ... Oil, Gas & Fossil Generation Facility, Nuclear Power), Industrial, ... Other) Are you looking for a definitive ... ...
(Date:4/4/2017)... YORK , April 4, 2017   EyeLock ... today announced that the United States Patent and Trademark ... patent broadly covers the linking of an iris image ... same transaction) and represents the company,s 45 th ... latest patent is very timely given the multi-modal biometric ...
(Date:3/30/2017)... , March 30, 2017 Trends, opportunities and ... and behavioral), by technology (fingerprint, AFIS, iris recognition, facial ... and others), by end use industry (government and law ... financial and banking, and others), and by region ( ... , Asia Pacific , and the ...
Breaking Biology News(10 mins):
(Date:4/25/2017)... Yorba Linda, Ca (PRWEB) , ... April 25, 2017 , ... ... latest webinar in the series will explore the laboratory testing for DIC in order ... a serious hypercoagulable disorder which can occur in hospitalized patients resulting in a high ...
(Date:4/25/2017)... San Diego, CA (PRWEB) , ... April 25, ... ... (CRO) division of L3 Healthcare, is pleased to announce the company is now ... data management. The iMedNet software certification enables the company’s clinical research team ...
(Date:4/25/2017)... ... April 25, 2017 , ... Dr. Robert ... P.A. , proudly announced today that acclaimed physiatrist Matthew Terzella, MD, has joined ... 15, 2017. , Dr. Terzella completed his residency in Physical Medicine and Rehabilitation ...
(Date:4/25/2017)... (PRWEB) , ... April 25, 2017 , ... Leaders of ... of Quorum, will be featured in multiple sessions at this week’s Association of ... emerging trends to best practices in clinical research. , "We are excited to present ...
Breaking Biology Technology: