Navigation Links
Predictors of cancer disease progression improve patient selection for metastasis-directed therapy
Date:12/11/2012

December 10, 2012, New York, NY Tumor metastasis, the ability of cancer cells to migrate from their tissue of origin and colonize elsewhere in the body, accounts for over 90% of cancer deaths. When patients die from cancer, it is usually caused by distant metastases established by malignant cells that split off from the primary cancer and began growing in new settings.

Scientists from the Ludwig Center at the University of Chicago hypothesized over 15 years ago that an intermediate state of tumor spread or metastasis exists between patients with extensive metastasis and patients whose disease stays confined to one local tumor with no spread. The scientists termed this intermediate state oligometastasis or metastasis limited in number and location. They then demonstrated that some patients with oligometastasis can be cured with therapies including surgery and radiotherapy that are directed locally at the metastasis.

In a paper published December 10 in PLOS ONE, the Ludwig investigators led by Dr. Ralph Weichselbaum in collaboration with Dr. Yves Lussier at the University of Illinois, took their research a step further. They analyzed patients with lung metastasis who underwent surgical resection with curative intent.

What they found was that some patients were cured, some developed rapid metastasis, and some developed metastasis at a very slow rate of progression. They then asked themselves what accounted for these radical differences in patient outcomes.

The answer: microRNAs or small molecules that suppress gene expression or protein synthesis. The investigators had pinpointed the culprit. They identified the microRNAs associated with oligometastatic progression and then found that these microRNAs differ from those associated with patients who developed widespread metastatic disease.

The microRNAs associated with oligometastasis have tumor suppressor characteristics that differ from microRNAs associated with patients who developed widespread metastatic disease. The results demonstrate a biological basis for oligometastasis and a potential for using microRNA expression to identify patients most likely to remain oligometastatic after metastasis-directed treatment.

"With these findings, we are now able to use microRNA expression to characterize oligometastasis and ultimately better select patients with tumor metastasis for curative interventions," said study author Ralph Weichselbaum, MD, director of the Ludwig Center for Metastasis Research at the University of Chicago. "Also understanding the molecular basis of tumor metastasis will allow for the targeting of specific biological processes to treat patients with more advanced tumor spread."


'/>"/>

Contact: Rachel Steinhardt
rsteinhardt@licr.org
212-450-1582
Ludwig Institute for Cancer Research
Source:Eurekalert

Related biology news :

1. Biologists engineer algae to make complex anti-cancer designer drug
2. Fred Hutchinson Cancer Research Center partners with GlaxoSmithKline to develop muscular dystrophy therapeutics
3. Stem cell research provides hope for infertile cancer survivors
4. TGen-US Oncology data guides treatment of metastatic triple-negative breast cancer patients
5. Clinical trial tests rice bran to prevent cancer
6. Nanotechnology drug delivery shows promise for treatment of pediatric cancer
7. Predicting the age at menopause of women having suffered from childhood cancers
8. Research shows immune system response is detrimental to novel brain cancer therapy
9. University of Tennessee researchers find fungus has cancer-fighting power
10. Newly discovered effects of vitamin D on cancer
11. Fruit fly studies guide investigators to misregulated mechanism in human cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/6/2017)... 5, 2017  SomaLogic announced today that it ... established by iCarbonX, the China ... "Global Digital Health Ecosystem that can define each ... individual,s biological, behavioral and psychological data, the Internet ... companies, SomaLogic will provide proteomics data and applications ...
(Date:12/22/2016)...  As part of its longstanding mission to improve genetic ... recently released its latest children,s book, titled The ... the topics of inheritance and variation of traits that are ... elementary school classrooms in the US. The ... Ariana Killoran , whose previous book with 23andMe, ...
(Date:12/16/2016)... , Dec. 16, 2016   IdentyTechSolutions America ... management products and solutions and a cutting-edge manufacturer ... that it is offering seamless, integrated solutions that ... entrance products. The solutions provide IdentyTech,s customers with ... their facilities from crime and theft. ...
Breaking Biology News(10 mins):
(Date:1/24/2017)... ... January 24, 2017 , ... Global Food Safety Resource ... its newly redesigned website, “GFSR 3.0,” which company CEO Tina Brillinger says features a ... more easily as we grow. , “We've spoken to many of our stakeholders and ...
(Date:1/24/2017)... , Jan. 24, 2017  Neogen Corporation (NASDAQ: ... its agreement with SenesTech Incorporated (NASDAQ: SNES ... rodenticide being developed by SenesTech. The two firms had ... when the SenesTech product was approved by the U.S. ... provided that the product could only be used by ...
(Date:1/24/2017)... 2017  Bruker today announced that it ... in the development, manufacture, and sale of ... innovative nanomechanical testing instruments to Bruker,s existing ... profilometers, and tribology and mechanical testing systems, ... research markets. Hysitron,s 2016 revenues were approximately ...
(Date:1/24/2017)... ... January 24, 2017 , ... ... biosensor assays for fragment-based screening, will showcase its proprietary Field ... Laboratory Automation and Screening (SLAS) conference in Washington, D.C. from Feb. 6 to ...
Breaking Biology Technology: