Navigation Links
Predicting risk of stroke from one's genetic blueprint
Date:2/25/2009

Boston, MAA new statistical model could be used to predict an individual's lifetime risk of stroke, finds a study from the Children's Hospital Informatics Program (CHIP). Using genetic information from 569 hospital patients, the researchers showed that their predictive model could estimate an individual's overall risk of cardioembolic stroke -- the most common form of stroke -- with 86 percent accuracy. The findings are reported in the March issue of Stroke.

"For complex diseases like stroke, it's not just a single mutation that will kill you," explains CHIP researcher Marco Ramoni, PhD, the study's senior author, who is also an Associate Professor at Harvard Medical School. "More likely it is an interaction of many factors."

Ramoni, in collaboration with Karen Furie, MD, the director of the stroke unit at Massachusetts General Hospital (MGH), and Rachel Ramoni, DMD, ScD, of the Harvard School of Dental Medicine, identified 569 patients that had presented to MGH's emergency department and outpatient neurology clinics between 2002 and 2005 with symptoms of suspected stroke. They collected genetic information from the 146 patients with confirmed cardioembolic stroke, and 423 controls who were followed and found not to have stroke, and looked for 1,313 genetic variants (called single nucleotide polymorphisms or SNPs) known to correlate with stroke. The SNPs that each patient had were then entered into the model -- known as a Bayesian network which not only identified the genetic variants that correlated with stroke, but also determined how these factors interplayed and the strength of these interactions.

"The model looks for factors, combines them and finds out which are the best predictive factors," explains Ramoni. "It's never one factor at a time, it's always more than one factor. What this technology allows you to do is to generate a network of factors that contribute to stroke."

The researchers found that the mode
'/>"/>

Contact: Keri Stedman
keri.stedman@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert

Page: 1 2

Related biology news :

1. UBC study establishes formula for predicting climate change impact on salmon stocks
2. Predicting acute GVHD by gene expression could improve liver stem cell transplant outcomes
3. Predicting the distribution of creatures great and small
4. Predicting the perfect predator
5. Predicting the radiation risk to ESAs astronauts
6. Predicting growth hormone treatment success
7. Trial seeks genetic fingerprint for predicting drug effectiveness
8. Researchers identify a cell type that limits stroke damage
9. Statins may treat blood vessel disorder that can lead to fatal strokes
10. Stroke Belt deaths tied to non-traditional risk factors
11. Study helps explain connection between sleep apnea, stroke and death
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... University, the Wellcome Trust Sanger Institute and the Swiss ... Mycobacterium pinnipedii from skeletons found in Peru which ... a relative of the TB bacterium that affects seals ... researchers assume that seals carried the pathogens from Africa ... was unexpected" comments Sebastien Gagneux, from the Swiss Tropical ...
(Date:8/20/2014)... melanomas the rare type of skin cancer that caused ... other more common types of skin cancer, according to a ... Cell & Melanoma Research . , Acral melanoma most often ... nail-beds and other hairless parts of the skin. Unlike other ... damage from the sun. , The team, from the Cancer ...
(Date:8/20/2014)... synthetic rugs and plastic bags could one day be ... than petroleum, scientists are now reporting. The novel process ... world deal with its agricultural and plastic waste problems, ... Athanassia Athanassiou, Ilker S. Bayer and colleagues at the ... is constantly growing. In 2012, its production reached 288 ...
Breaking Biology News(10 mins):Scientists learn more about rare skin cancer that killed Bob Marley 2
... made of bamboo now stands in Changsha, Hunan Province, China. ... at the USC Viterbi School of Engineering and also a ... Composite Structures of the Hunan University, China designed and constructed ... world. It uses the GluBam technology invented by ...
... A new therapy for metastatic prostate cancer has shown considerable ... become resistant to current drugs. , Of 30 men ... multisite phase I/II trial designed to evaluate safety, 22 showed ... (PSA) in their blood. Phase III clinical trials are planned ...
... As the U.S. Southwest grew warmer between 18,700 and 10,000 ... Mojave Desert, robbing woodrats of their favorite food. Now ... the rodents eat the toxic creosote bushes that replaced junipers. ... biologist Denise Dearing of the University of Utah, lead author ...
Cached Biology News:A full-sized California-style home made of bamboo 2New medications show promise in treating drug-resistant prostate cancer 2New medications show promise in treating drug-resistant prostate cancer 3New medications show promise in treating drug-resistant prostate cancer 4Desert woodrats switch one dietary poison for another 2
(Date:8/20/2014)... August 20, 2014 GraphDB™ ... today including improvements to the enterprise replication cluster, ... for Lucene, SOLR and Elasticsearch. This release happens ... high performance triplestore – GraphDB™ was formerly known ... deploying the only mature enterprise resilient RDF triplestore ...
(Date:8/19/2014)... 2014 Shimadzu Scientific Instruments has ... and Nexera-i, adding to the company’s extensive line-up ... an intuitive operating environment, and full automation, the ... workflow for conventional to ultra-high-speed analysis. ... intelligent design so users can begin building the ...
(Date:8/19/2014)... , Aug. 19, 2014 A Geisinger ... been nominated for a Centers for Disease Control and ... a major public health concern. Joseph ... is one of a team of researchers nominated for ... C. Shepard Science Award for Data Methods and Study ...
(Date:8/19/2014)... Aug. 19, 2014 Research and Markets  has ... (SOFCs) - Global Strategic Business Report" report to their ... for Solid Oxide Fuel Cells (SOFCs) in US$ Thousands. The ... Canada , Europe , ... forecasts are provided for the period 2012 through 2020. Market ...
Breaking Biology Technology:Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 3Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 4Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 3Geisinger investigator nominated for federal award 2Geisinger investigator nominated for federal award 3Global Solid Oxide Fuel Cells (SOFCs) - Strategic Business Report 2014 2
... Israel, October 15 ,Simbionix USA Corporation is pleased ... of growth capital financing led by River Cities ... and other existing,shareholders, as well as Western Reserve ... investment will enable Simbionix to,accelerate the already rapid ...
... Inc.,(Nasdaq: SUPG ), a pharmaceutical company dedicated ... today announced the company,s plans,to present five posters ... Cancer Therapeutics" on October 23 and 24, 2008., ... advances,in the following compounds: MP-470, SGI-1776 and SGI-1252. ...
... 15 Cepheid (Nasdaq:,CPHD) today announced the ... Xpert(TM) MRSA/SA Skin and Soft Tissue Infection ... Laboratory Improvement Amendments,(CLIA). The new test is ... (MRSA) and Staphylococcus,aureus (SA), (typically Methicillin-sensitive) in ...
Cached Biology Technology:Simbionix Raises Largest Amount in Company's History in Venture Capital to Accelerate Growth 2Simbionix Raises Largest Amount in Company's History in Venture Capital to Accelerate Growth 3SuperGen to Present Data at EORTC-NCI-AACR 2Cepheid Molecular Diagnostic Test for MRSA and S. aureus Categorized 'Moderate Complexity' by FDA 2Cepheid Molecular Diagnostic Test for MRSA and S. aureus Categorized 'Moderate Complexity' by FDA 3Cepheid Molecular Diagnostic Test for MRSA and S. aureus Categorized 'Moderate Complexity' by FDA 4
... variety of environmental and pathophysiological stressful conditions ... proteins known as heat shock proteins (HSPs), ... (SRPs). The Hsp90 family of proteins ... and beta, Grp94, and Trap-1 (Hsp75). It ...
... (AR) Competitor Assay Kits provide a sensitive ... potential AR ligands using fluorescence polarization (FP). ... domain protein tagged with His and GST ... androgen ligand (Fluormone AL Green in the ...
Custom LNA Oligonucleotide synthesis ,High quality Custom LNA Oligonucleotides are available for a variety of different specialty applications and innovative products. ,Please inquire for further...
... - with a modular approach to instrument ... ChemStation Plus NDS family provides modular software ... data management, giving you the flexibility to ... needs now and that can grow as ...
Biology Products: