Navigation Links
Predicting growth hormone treatment success
Date:12/12/2007

Growth hormone treatments work better on some children than on others, but judging which candidates will gain those vital inches in height is no simple task. Now researchers have developed a new mathematical model which predicts the optimal dose of growth hormone to treat children who are abnormally short for a wide range of reasons. A study published in the online open access journal BMC Medical Informatics and Decision Making describes a model that can be more widely applied than previous versions, with greater predictive accuracy.

Jovanna Dahlgren and colleagues at Gothenburg University in Sweden analysed data from 415 short prepubertal children who had undergone GH treatment to develop a model that predicts an individuals response. The team gathered data including the childrens length and weight at birth, height before and during treatment and their parents height. The model was then validated by applying it to a group of 112 different children. The models accuracy was substantially improved by including data on blood levels of growth hormone and other growth-related hormones, such as insulin-like growth factors and leptin.

Dr Dahlgren states, The models presented serve as a practical clinical tool for selecting children for successful growth hormone treatment ... and provide the highest prediction accuracy available.

Growth hormone treatments are expensive, involve daily injections, and are associated with the risk of overdose. To assess whether growth hormone treatment would be appropriate for a particular child, an accurate prediction of how much growth would result from the treatment is crucial. This new research will help clinicians determine the children most likely to benefit from treatment, and the most appropriate dose.


'/>"/>

Contact: Charlotte Webber
press@biomedcentral.com
44-020-763-19980
BioMed Central
Source:Eurekalert

Page: 1

Related biology news :

1. Trial seeks genetic fingerprint for predicting drug effectiveness
2. Circadian clock controls plant growth hormone
3. Population movements and money remittances spur forest regrowth
4. Paracetamol, one of most used analgesics, could slow down bone growth
5. Targeting nerve growth factor may cure liver cancer
6. Study shows vitamin C is essential for plant growth
7. Study reveals a key to blood vessel growth and possible drug target
8. Brain cell growth diminishes long before old age strikes, animal study shows
9. Sea cucumbers fast track organ regrowth by healing their wounds
10. Pourquie Lab demonstrates role of growth factor in vertebrae formation
11. Cold Spring Harbor Protocols highlights a method that captures cell growth and activity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2016)... April 20, 2016 The new ... a compact web-based "all-in-one" system solution for all door ... reader or the door interface with integration authorization management ... control systems. The minimal dimensions of the access control ... the building installations offer considerable freedom of design with ...
(Date:4/15/2016)... Research and Markets has announced ... 2016-2020,"  report to their offering.  , ... global gait biometrics market is expected to grow ... 2016-2020. Gait analysis generates multiple variables ... to compute factors that are not or cannot ...
(Date:4/13/2016)... April 13, 2016  IMPOWER physicians supporting Medicaid patients ... a new clinical standard in telehealth thanks to a ... the higi platform, IMPOWER patients can routinely track key ... body mass index, and, when they opt in, share ... visit to a local retail location at no cost. ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... ... Researchers at the Universita Politecnica delle Marche in Ancona combed medical journal ... Their findings are the subject of a new article on the Surviving Mesothelioma website. ... the blood, lung fluid or tissue of mesothelioma patients that can help point doctors ...
(Date:6/23/2016)... SPRING, Md. , June 23, 2016 A ... collected from the crime scene to track the criminal down. ... and the U.S. Food and Drug Administration (FDA) uses DNA ... Sound far-fetched? It,s not. The ... genome sequencing to support investigations of foodborne illnesses. Put as ...
(Date:6/23/2016)... FRANCISCO , June 23, 2016   EpiBiome ... has secured $1 million in debt financing from Silicon ... ramp up automation and to advance its drug development ... its new facility. "SVB has been an ... beyond the services a traditional bank would provide," said ...
(Date:6/23/2016)... 2016  Blueprint Bio, a company dedicated to identifying, ... community, has closed its Series A funding round, according ... "We have received a commitment from Forentis Fund ... to meet our current goals," stated Matthew Nunez ... to complete validation on the current projects in our ...
Breaking Biology Technology: