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Predicting antibiotic resistance among goals of UH research
Date:12/17/2013

HOUSTON, Dec. 17, 2013 Going back in time to compare evolutionary changes in several thousand generations of E. coli, a University of Houston (UH) biologist hopes to one day be able to isolate a bacterial pathogen and predict the likelihood it will become resistant to a particular antibiotic.

A five-year, $967,431 National Science Foundation CAREER Award is allowing associate professor Timothy Cooper and his team to study the causes and consequences of evolvability in bacterial populations. Better understanding the genetic and physiological bases of evolvability is important in vaccine and antibiotic design, as well as in biotechnology. The ultimate goal is to counter it in the former, while exploiting it in the latter.

"Evolvability is when biological populations have the capacity to adapt to changing conditions," Cooper said. "By studying how generations of bacteria evolve over time, we are learning ways to predict the outcome of the changes and to understand what drives the differences in the way strains of bacteria evolve. We hope this type of evolutionary biology research will impact medical care by contributing to the ability to predict the evolutionary paths of bacterial populations."

Evolvability plays a crucial role in determining evolutionary winners and losers among the many variants that arise in any bacterial population in that they are either improved or become extinct. Through his research, Cooper wants to gain the ability to predict these winners and losers, because this knowledge gives an element of predictability to evolution. This would predict such things as antibiotic resistance.

Cooper's evolvability research with the E. coli began two years ago with the first petri dish of this fast-growing bacteria. He says they are lucky, because the experiments are incredibly simple. His team grew the initial bacteria in a petri dish and took a sample to grow in a test tube with fresh media. That p
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Contact: Lisa Merkl
lkmerkl@uh.edu
713-743-8192
University of Houston
Source:Eurekalert  

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