Navigation Links
Preclinical study shows potential of new technologies to detect response to cancer therapy earlier
Date:2/20/2013

The research was published early in the January issue of the journal Technology in Cancer Research and Treatment. The article describes experiments using ultrasonic molecular imaging (USMI) and Dynamic Contrast Enhanced-Perfusion Imaging (DCE-PI) to measure response to therapy for pancreatic cancer.

Paul Dayton, PhD, senior author says, "What we found is that using two non-invasive technologies, we can detect response to therapy earlier than by relying on tumor volume changes. Having new non-invasive, inexpensive technologies available to measure response to therapy earlier during the course of treatment would be a significant advance in the ability to tailor a person's treatment to improve outcomes."

Dr. Dayton, an Associate Professor of Biomedical Engineering, worked with Jen Jen Yeh, MD, Associate Professor of Surgery and Pharmacology, to evaluate the imaging technologies on human pancreatic cancer in a pre-clinical model. Both faculty are members of the Lineberger Comprehensive Cancer Center.

USMI has the ability to characterize non-invasively the biologic processes at the cellular and molecular levels. It does this through the use of targeted contrast agents, which are markers that bind to specific proteins expressed on cancer cells within the body. These contrast agents enable a standard ultrasound system to detect signals from cancer cells that would otherwise be undetectable.

Ultrasound DCE-PI is a method used to non-invasively monitor the blood flow in the microcirculation. Since growing tumors require abnormally increased blood flow, changes in blood vessel structure or density can provide information regarding tumor malignancy.

The team used a drug that inhibits a protein specific to tumors. They then used the imaging tools to measure the response of two different tumors, one known to respond to the drug therapy, and a second known not to respond. The results indicated that USMI was able to detect molecular signs of tumor response to therapy after only 2 days. A change in blood flow in the tumor was observed to detect response after day 14 using DCE-PI. Over the same period, standard volume measurements were not able to detect therapeutic response, and prior studies suggested that volume measurements do not become indicative of response until approximately 28 days. Thus, these methods showed a notable improvement in the early identification of tumor response to therapy, using contrast enhanced ultrasound imaging.

Although the contrast agents for USMI are not yet available in the United States, they are currently in clinical trials in Europe for cancer imaging.


'/>"/>

Contact: Dianne Shaw
dgs@med.unc.edu
919-966-7834
University of North Carolina Health Care
Source:Eurekalert  

Related biology news :

1. Preclinical studies use specialized ultrasound to detect presence of cancer
2. Collaborative preclinical efficacy studies suggest a new target for drug addiction treatment
3. Virology researcher awarded nearly $2 million to study chronic hepatitis E
4. New study shows how seals sleep with only half their brain at a time
5. Study shows that diet of resistant starch helps the body resist colorectal cancer
6. Breakthrough study opens door to broader biomedical applications for Raman spectroscopy
7. Phosphorus starvation linked to symptoms of citrus disease Huanglongbing in new study
8. Yale Study links common chemicals to osteoarthritis
9. CU-Boulder amphibian study shows how biodiversity can protect against disease
10. Busy beavers give Canada geese a lift, study shows
11. Video study shows which fish clean up coral reefs, showing importance of biodiversity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Preclinical study shows potential of new technologies to detect response to cancer therapy earlier
(Date:4/4/2017)...   EyeLock LLC , a leader of iris-based ... Patent and Trademark Office (USPTO) has issued U.S. Patent ... an iris image with a face image acquired in ... 45 th issued patent. "The ... the multi-modal biometric capabilities that have recently come to ...
(Date:3/30/2017)... KONG , March 30, 2017 The ... a system for three-dimensional (3D) fingerprint identification by adopting ground breaking ... into a new realm of speed and accuracy for use in ... at an affordable cost. ... ...
(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
Breaking Biology News(10 mins):
(Date:5/26/2017)... , ... May 25, 2017 , ... LabRoots , ... engineers, and scientists from around the world, is announcing a new textbook scholarship, the ... both undergraduate and graduate students, 17 years or older, pursuing a degree in one ...
(Date:5/24/2017)... ... May 23, 2017 , ... Federal funding for basic and applied scientific ... life-saving medical and other vital technologies — deserves continued support, say leaders of ... scientific community today in responding to the President’s budget request for Fiscal Year 2018. ...
(Date:5/23/2017)... ... May 23, 2017 , ... A recent survey conducted by ... and difficult to control weed in 12 categories of broadleaf crops, fruits and vegetables, ... scientists across the U.S. and Canada participated in the 2016 survey, the second conducted ...
(Date:5/23/2017)... ... 22, 2017 , ... A new Technology Hot Topics session ... August will feature high-level speakers on quantum devices, graphene electronic tattoo sensors, augmented ... the largest multidisciplinary optical sciences meeting in North America, will run 6-10 August ...
Breaking Biology Technology: