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Precise docking sites for cells
Date:12/11/2013

d. For coating the scaffold, the team of Barner-Kowollik and Martin Bastmeyer uses various bioactive molecules and a photoactive group. Coupling is activated at the points illuminated by the laser beam only. There, bioactive molecules bind chemically to the surface. The physico-chemical properties and parameters, such as the flexibility or three-dimensional arrangement of cell docking sites, can be adjusted with a high local resolution when using these modern photochemical methods.

A whole set of photochemical surface coding methods is now presented by six publications in the latest issues of the magazines Angewandte Chemie, Chemical Science, and Advanced Materials. Using this set of methods, chemical bonds can be produced efficiently and in a locally controlled manner without catalysts or increased temperatures being required. Depending on the application, it is possible to maximize coupling efficiency, to accelerate the photoreaction, to directly couple to unmodified biomarkers, to reduce chemical synthesis work, or to design areas where no cell adhesion can take place.


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Contact: Monika Landgraf
presse@kit.edu
49-721-608-47414
Helmholtz Association
Source:Eurekalert  

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