Navigation Links
Pre-cancerous condition linked to chronic acid reflux faces several hurdles
Date:8/7/2008

A pre-cancerous condition linked to chronic acid reflux often gets overlooked. Can the medical community do a better job intervening? Researchers from the Hutchinson-MRC Research Centre in Cambridge think so.

In a review published in the inaugural issue of Disease Models & Mechanisms (DMM), http://dmm.biologists.org, experts on a disease known as "Barrett's oesophagus" discuss how "Barrett's" presents unique challenges in diagnosis and treatment. They cite key factors which make this illness difficult to detect, and suggest how scientists and doctors can team up to improve the odds of intervention.

Doctors want to understand more about this condition because patients with Barrett's have 30 to 125 times increased risk of an often fatal cancer of the oesophagus. One of the most common indicators of Barrett's is severe and chronic acid reflux. The authors of the review article discuss several reasons why most Barrett's cases are undiagnosed. The wide-spread availability of over-the-counter antacid medications may contribute by suppressing symptoms such that only the most severe and persistent cases of acid reflux are recommended for screening. Additionally, in order to screen for Barrett's, the oesophagus must be examined with a small light and camera (endoscope) which is not a routine procedure.

The biological basis of Barrett's is an abnormal change, or dysplasia, in the oesophagus. Normally, the oesophagus is lined with flat-shaped cells known as squamous cells. However, in patients with Barrett's, the cell lining consists of rectangular-shaped columnar cells. This process of normal cells morphing into abnormal cells is common to several types of cancer, not just oesophageal cancer. Thus, a greater understanding of Barrett's can also lead to potential therapies for similar pre-cancerous conditions.

In order to advance the diagnosis of Barrett's oesophagus, researchers recommend identifying standardized indicators which can be used to identify the presence of Barrett's as well as predict the likelihood that it will progress into cancer. Additionally, they recommend developing less costly screening methods to allow routine checks for Barrett's in patients with acid reflux. They point out the need for developing laboratory animal models of this disease in order to study the underlying molecular mechanisms of Barrett's, as well as to test potential novel therapies.


'/>"/>

Contact: Nick Birch
nick@biologists.com
44-122-342-6164
The Company of Biologists
Source:Eurekalert

Related biology news :

1. Condition of bluefin tuna in gulf of maine is declining
2. Family conditions may affect when girls experience puberty
3. Unfavorable ocean conditions likely cause of low 2007 salmon returns along West Coast
4. Changes in ocean conditions in Sargasso Sea potential cause for decline in eel fishery
5. New study changes conditions for Spanish brown bears
6. Ancient protein offers clues to killer condition
7. Purple extremist thrives under inhospitable conditions
8. NOAA report states half of US coral reefs in poor or fair condition
9. Risk of common vaginal infection linked to preterm birth appears higher for blacks
10. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
11. Protein chatter linked to cancer activation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/4/2017)... , April 4, 2017   EyeLock LLC , ... that the United States Patent and Trademark Office (USPTO) ... covers the linking of an iris image with a ... and represents the company,s 45 th issued patent. ... is very timely given the multi-modal biometric capabilities that ...
(Date:3/30/2017)... March 30, 2017 Trends, opportunities and forecast ... behavioral), by technology (fingerprint, AFIS, iris recognition, facial recognition, ... others), by end use industry (government and law enforcement, ... and banking, and others), and by region ( ... Asia Pacific , and the Rest ...
(Date:3/24/2017)... Controller General of Immigration from Maldives Mr. Mohamed Anwar and ... international IAIR Award for the most innovative high security ePassport and eGates  ... ... Maldives Immigration Controller General, Mr. Mohamed Anwar ... right) have received the IAIR award for the "Most innovative high security ...
Breaking Biology News(10 mins):
(Date:6/26/2017)... ... , ... Third Wave Bioactives, LLC announces the addition of Brett Thompson. Brett ... development and ensuring quality customer experience. , Brett brings to Third Wave ... marketing and sales roles. “Brett’s background working with customers and eye for market opportunities ...
(Date:6/23/2017)... Frederick, MD (PRWEB) , ... June 23, 2017 ... ... laboratory software solutions provider, announced the latest version of LimitLIS®, its rapidly growing ... designed to speed up user adoption, ensure installation integrity, and provide more customization ...
(Date:6/22/2017)... ... June 21, 2017 , ... Beaker, the industry’s pioneer ... the life sciences industry, today announces a strategic partnership with Alcami Corporation, a ... advantage of Beaker’s expertise in executive recruitment solutions, providing Alcami with access to ...
(Date:6/22/2017)... (PRWEB) , ... June 22, 2017 , ... ... health leaders in designating infertility as a disease, bringing new hope for prospective ... at their 2017 annual meeting to back the World Health Organization’s designation in ...
Breaking Biology Technology: