Navigation Links
Poxvirus potency uncovered in new atomic map
Date:2/1/2008

BIRMINGHAM, Ala. Scientists at the University of Alabama at Birmingham (UAB) and Saint Louis University used X-ray crystallography to uncover new details about the infectious potency of poxviruses, furthering the understanding of how one protein in viral infections can subvert the bodys immune system.

Having high-resolution detail of this protein on hand will speed the discovery of new drugs to combat inflammation and immune diseases such as atherosclerosis and rheumatoid arthritis, the researchers said.

The findings are published in the online edition of journal Proceedings of the National Academy of Sciences and will soon appear in a print edition.

Now we have a visual blueprint to guide our future studies on interferon-gamma binding protein, which one day may be used to prevent inflammatory disease, said Mark R. Walter, Ph.D., an associate professor in the UAB Department of Microbiology and senior author on the study.

Interferon-gamma binding protein (IFN-y) is notorious for the role it plays in helping poxviruses replicate. Normally when a virus enters the bloodstream, the immune system fights back by producing IFN-y, which tells surrounding cells to fight the infection.

Remarkably, somewhere during the evolution of the poxvirus, it captured an IFN-y gene from its host and incorporated some of the protein structure into its own. As a result poxvirus has a very efficient blocker of the IFN-y antiviral response, Walter said.

The new study shows this blocking ability through crystallography, the science of mapping the atomic structure of molecules by looking at their interaction with an X-ray beam.

Poxviruses include many classes of the invasive organism such as smallpox, cowpox and monkeypox. Smallpox in particular has played a tragic role in human history: estimates show it caused between 300 million and 500 million deaths in the 20th Century.

Smallpox was declared officially e
'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham
Source:Eurekalert

Page: 1 2

Related biology news :

1. Agent that triggers immune response in plants is uncovered
2. Hemoglobin uncovered
3. Anthrax cellular entry point uncovered
4. Scientists retrace evolution with first atomic structure of an ancient protein
5. Atomic bomb survivor, scientists mark 60 years of long-term radiation study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/15/2014)... , Nov. 13, 2014  While we may still be ... McCoy used in "Star Trek" to gain instant access to ... to work with smartphones and tablets for monitoring and measuring ... healthcare world. This may seem a tad Orwellian to some, ... adopt some of these technological opportunities into their healthcare regime. ...
(Date:11/7/2014)... 7, 2014  In conjunction with the Glendale ... The Community Foundation of the Verdugos has announced the " ... PROJECT," a $250,000 initiative to keep the Verdugo Regional Crime ... first six months of existence, the Lab has processed more ... local law enforcement. "Because our number one priority ...
(Date:11/6/2014)... 6, 2014 - Insilico Medicine, Inc, a Baltimore-based ... age related diseases announced a research collaboration with ... Champions Oncology, Inc (OTC: CSBR). , "There are ... medicine, but Champions Oncology,s TumorGraft technology is unique ... chemotherapy regimen experimentally generating vast amounts of valuable ...
Breaking Biology News(10 mins):Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2
... shady pursuit of endangered bird eggs made international headlines ... most notorious illegal egg collector, died after falling from ... The Royal Society for the Protection of Birds estimates ... are targeted by collectors. Classical economics theory predicts that ...
... world's oceans to land about 415 million years ago, then ... record contains few examples of animals with backbones for the ... again, this time for good. , The mysterious lull in ... for the Yale University paleontologist, Alfred Romer, who first recognized ...
... games this holiday season because the fun of playing ... , Psychologists at the University of Rochester, in collaboration ... 1,000 gamers what motivates them to keep playing. The ... month suggest that people enjoy video games because they ...
Cached Biology News:A human taste for rarity spells disaster for endangered species 2A human taste for rarity spells disaster for endangered species 3Steep oxygen decline halted first land colonization by Earth's sea creatures 2A reason why video games are hard to give up 2
(Date:11/26/2014)... NJ (PRWEB) November 25, 2014 ... has officially joined the Morris County (New Jersey) ... which is a leading business organization in the ... opportunity to further engage some key clients in ... operations in the geographic area. Membership enables Whitehouse ...
(Date:11/26/2014)... The Pittcon marketing department is pleased to announce ... app, Pittcon 2015 . The ... for iOS and Android devices and the Kindle Fire, ... after the event. It acts as an all-inclusive real-time ... Conferee Networking sessions and short courses. , The Pittcon ...
(Date:11/26/2014)... and WILMINGTON, DE (PRWEB) November 26, 2014 ... Annual MPN Heroes recognition reception on December 5, 2014, ... Hematology’s annual meeting. The MPN Heroes event will honor ... in the field of myeloproliferative neoplasms (MPNs). , ... "Nashville," will discuss his family's cancer journey at the ...
(Date:11/26/2014)... TOKYO , 25 novembre 2014 /PRNewswrie/ -- Theravalues ... per il mercato europeo in occasione di Hi Europe ... ). Si tratta della curcumina con ... tecnologia amorfa (senza cristalli) e ingredienti approvati dalle norme ... presente nella spezia della pianta curcumina ( Curcuma longa ...
Breaking Biology Technology:Whitehouse Laboratories Joins Morris County Chamber of Commerce 2Whitehouse Laboratories Joins Morris County Chamber of Commerce 3Pittcon Releases 2015 Mobile App 2CURE Magazine and Incyte to Honor MPN Heroes 2CURE Magazine and Incyte to Honor MPN Heroes 3CURE Magazine and Incyte to Honor MPN Heroes 4La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 3
... October 20 Speaking in Rome, Italy today ... Foundation,(IOF) CEO Patrice McKenney called for individuals and ... osteoporosis. "Osteoporosis is a common but,devastating disease which ... taken to reduce the burden of osteoporotic fractures ...
... Air Force-funded researcher, Dr. scar Custance from the National Institute ... 2009 Feynman Prize for Experimental Work in Nanotechnology for his ... research could someday lead to more effective catalysts for the ... experimental work will be awarded in January 2010 near Palo ...
... Neurobiological Technologies, Inc. (Nasdaq: NTII ) ("NTI") announced ... Market LLC ("NASDAQ") that NTI intends to file a Form ... about October 28, 2009 to effect the voluntary delisting of ... dissolution of the company pursuant to a Plan of Complete ...
Cached Biology Technology:World Osteoporosis Day Call for Immediate Action to Prevent Fractures 2Researcher honored for experimental work in nanotechnology 2
... a DNA sequencing service. We can sequence ... products, BACs, etc. Our DNA sequencing service ... plasmids or purified PCR products. We use ... automated reaction setup and dye terminator removal. ...
... The BD FACSAria cell sorter sets ... cytometry. Based on a revolutionary new ... delivers high-speed sorting and multicolor analysis. The ... sorter that incorporates a fixed-alignment cuvette flow ...
Mouse polyclonal antibody raised against a partial recombinant AGTRAP. NCBI Entrez Gene ID = 57085...
...
Biology Products: