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Powerful sequencing technology decodes DNA folding pattern
Date:4/11/2012

billion base pairs in size," explained lead researcher, Jesse Dixon, a graduate student in Dr. Ren's lab.

In examining the interaction map, Dr. Ren's team discovered that topological domains are the basic unit of folding. The team confirmed their findings by comparing it among different cell types. In each type, the folding of DNA into topological domains was constant.

A parallel study by researchers at Institut Curie and the University of Massachusetts Medical School support Ludwig researchers' findings. By focusing on the mouse X chromosome segment in embryonic stem cells, as well as neuronal cells and fibroblasts, researchers showed that this segment adhered to similar folding patterns as the ones found by Ren's team. They further showed that this organization could be linked to gene regulation.

"This is just the beginning of a very exciting area of research focused on the understanding of nuclear processes from a three-dimensional point of view. We know that some cancers, including many leukemias, are caused by the translocation of two genes. It's not clear how these translocations are regulated or whether they result from random events. It's possible that the spatial structure of the chromosome can provide clues about how these translocations occur and, more importantly, how we can prevent them or at least mitigate their effect," concluded Dr. Ren.


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Contact: Rachel Steinhardt
rsteinhardt@licr.org
212-450-1582
Ludwig Institute for Cancer Research
Source:Eurekalert

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