Navigation Links
Powerful sequencing technology decodes DNA folding pattern
Date:4/11/2012

New York, NY, April 11, 2012 Chromosomes are strands of DNA that contain the blueprint of all living organisms. Humans have 23 pairs of chromosomes that instruct how genes are regulated during development of the human body. While scientists have developed an understanding of the one-dimensional structure of DNA, until today, little was known about how different parts of DNA are folded next to each other inside the nucleus.

Using a powerful DNA sequencing methodology, researchers at the Ludwig Institute for Cancer Research have now investigated the three-dimensional structure of DNA folds in the nucleus of a chromosome. The findings published in the April 11 issue of Nature provide scientists with a greater understanding about the basic principles of DNA folding and its role in gene regulation.

"In any biology textbook, when you look at a diagram of how genes are depicted, it is invariably a one-dimensional line. In reality, genes are arranged in such a way that two parts of the gene may be distal to each other linearly, but very close in 3-D," said Dr. Bing Ren, Member of the Ludwig Institute for Cancer Research and Professor of Cellular and Molecular Medicine at the University of California, San Diego. "With the knowledge of how DNA folds inside the nucleus, we now have a more complete picture of the regulatory process of genes. That is the primary reason we sought to tackle this problem." The spatial organization is intimately linked to its role in the body.

Ludwig researchers used a sequencing-based method called Hi-C to examine the 3-D structure of chromosomes. "With this technology, we were able to build a map of pair-wise interactions from each chromosome, and from that, extrapolate the basic folding pattern of the DNA. What we learned is that they fold into many local domains termed topological domains, which are on average one million base pairs in size. By way of comparison, the whole human genome is just over three
'/>"/>

Contact: Rachel Steinhardt
rsteinhardt@licr.org
212-450-1582
Ludwig Institute for Cancer Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Apelin hormone injections powerfully lower blood sugar
2. Powerful online tool for protein analysis provided pro bono by Stanford geneticist
3. Newly identified gene powerful predictor of colon cancer metastasis
4. Biologists learn structure, mechanism of powerful molecular motor in virus
5. Cancer Genomics Browser gives cancer researchers a powerful new tool
6. Collaboration leads to success: Most powerful computer of its kind in western N.Y. available worldwide
7. InVitria to Unveil Powerful Cell Culture Media Component ZAP-CHO
8. Changing climate likely to make super weed even more powerful
9. Powerful nutrient cocktail can put kids with Crohns into remission
10. Powerful new molecular GPS helps probe aging and disease processes
11. Innovative Document Security Technology Proves Powerful in Avoiding Counterfeit Products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... DUBAI , April 20, 2015 ... soars   Glenbeigh Records Management (GRM), ... contract with Dubai Islamic Bank. Having built up an impressive ... is now a leading player within the records management sector ... company expects to double is GCC staffbase and employ a ...
(Date:4/13/2015)... , April 13, 2015 ... Research, "Global Biometrics Market Forecast & Opportunities, 2020", the ... CAGR of around 14% till 2020. The biometrics ... large scale implementation and review of biometric management ... of new products with greater efficiency, are resulting ...
(Date:4/8/2015)... 2015  Infinisource, a leading provider of SaaS-based Human ... a leading supplier of biometric identification and security ... most advanced biometrically-enabled time clock, the companies announced ... is setting a bold, new standard for the ... small and mid-size employer. When connected to the ...
Breaking Biology News(10 mins):Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3
... Synaptics,(Nasdaq: SYNA ), a leading developer ... entertainment devices, today reported,financial results for the first ... reflect the expensing of non-cash share-based,compensation for all ... quarter of fiscal 2009 was $115.9 million, an,increase ...
... induce "synesthetic" experiences where one sense triggers the ... according to a new study in the journal ... for Psychological Society. The findings suggests that ... necessarily have extra connections in their brain; rather, their ...
... The Office of Dietary Supplements (ODS) at the National ... ninth issue of the Annual Bibliography of Significant Advances ... 2007 Bibliography include research supported by government, industry, and ... research covers a wide array of laboratory, human studies, ...
Cached Biology News:Synaptics Reports Record Results for First Quarter of Fiscal 2009 2Synaptics Reports Record Results for First Quarter of Fiscal 2009 3Synaptics Reports Record Results for First Quarter of Fiscal 2009 4Synaptics Reports Record Results for First Quarter of Fiscal 2009 5Synaptics Reports Record Results for First Quarter of Fiscal 2009 6Synaptics Reports Record Results for First Quarter of Fiscal 2009 7Synaptics Reports Record Results for First Quarter of Fiscal 2009 8Ben-Gurion University of the Negev researchers help find that hypnosis can induce synesthesia 2Annual Bibliography of Significant Advances in Dietary Supplement Research 2007 2
(Date:5/21/2015)... 21, 2015  CytRx Corporation (NASDAQ: CYTR ... in oncology, today announced positive updated results from ... for the treatment of unresectable glioblastoma multiforme (GBM), ... multisite trial is designed to investigate the preliminary ... tumors have progressed following prior treatment with surgery, ...
(Date:5/21/2015)... Veolia’s environmental monitoring technology division, ... distribution agreement with VWR to distribute TECTA™ B16, ... than 160 years of experience, VWR, a leading ... and production facilities, has cultivated a value proposition ... to enable science. Endetec’s TECTA™ B16, combines ...
(Date:5/20/2015)... 2015 This year has been one ... US Patented Pearl’s Premium Ultra Low Maintenance Lawn ... country that are coming out of record bad weather. ... of major global concerns related to water, health, and ... the alternative to the standard, water-wasting, chemical-treated standard lawn. ...
(Date:5/20/2015)... , May 20, 2015  Health eCareers, ... short-staffed healthcare organizations with job seekers looking for ... , a new mobile and online tool dedicated ... healthcare industry. SHIFT enables employers to ... tenens, travel nursing, per diem and other temporary ...
Breaking Biology Technology:CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 2CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 3CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 4CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 5CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 6CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 7Veolia’s TECTA™ B16 Instrument for E. Coli Detection is Offered Exclusively Through VWR 2Breakthrough 4th Generation Low Maintenance Lawn Seed Offers Solution to California Drought 2Health eCareers Launches SHIFT Mobile and Online Tool to Match Healthcare Employers with Temporary Job Seekers 2Health eCareers Launches SHIFT Mobile and Online Tool to Match Healthcare Employers with Temporary Job Seekers 3
... 2011 Pacific Shore Holdings, Inc. (previously Green Shores, Inc.), ... from the Financial Industry Regulatory Authority ("FINRA") for the change ... about the symbol change, as it takes us one step ... Markets. "Once we enter the Public Marketplace, we believe that ...
... IPSWICH, Mass., Feb. 14, 2011 New England Biolabs has ... ™ and One Taq Hot Start DNA Polymerases. Optimized ... DNA Polymerases, these new products offer robust amplification across a ... The 3´–5´ exonuclease activity of Deep Vent increases the fidelity ...
... Technology Catalysts International (TCI), leading global consultants to the ... in drug delivery have identified parenteral depots as key ... a different pathway for new drug development, and potential ... a crowded pharmaceutical field. In general, biopharmaceuticals ...
Cached Biology Technology:Pacific Shore Holdings, Inc. Receives Symbol Change Approval From FINRA 2New England Biolabs Introduces OneTaq™ DNA Polymerase, a Robust Solution for Routine and Difficult PCR 2Parenteral Depots Offer $8 Billion of Reformulation Opportunities and a Strong Competitive Edge in Crowded Pharmaceutical Space 2
Preadipocyte factor-1 [Pref-1, DLK-1], C-terminal...
Bag-1 (K-20)...
IC50: 35 ng/ml · Limit of detection: 8 ng/ml...
... PGE2-d4 contains 4 deuterium atoms at ... It is intended for use as an ... E2 (PGE2) by GC- or LC-mass spectrometry. ... products of arachidonic acid and one of ...
Biology Products: