Navigation Links
Powerful sequencing technology decodes DNA folding pattern
Date:4/11/2012

New York, NY, April 11, 2012 Chromosomes are strands of DNA that contain the blueprint of all living organisms. Humans have 23 pairs of chromosomes that instruct how genes are regulated during development of the human body. While scientists have developed an understanding of the one-dimensional structure of DNA, until today, little was known about how different parts of DNA are folded next to each other inside the nucleus.

Using a powerful DNA sequencing methodology, researchers at the Ludwig Institute for Cancer Research have now investigated the three-dimensional structure of DNA folds in the nucleus of a chromosome. The findings published in the April 11 issue of Nature provide scientists with a greater understanding about the basic principles of DNA folding and its role in gene regulation.

"In any biology textbook, when you look at a diagram of how genes are depicted, it is invariably a one-dimensional line. In reality, genes are arranged in such a way that two parts of the gene may be distal to each other linearly, but very close in 3-D," said Dr. Bing Ren, Member of the Ludwig Institute for Cancer Research and Professor of Cellular and Molecular Medicine at the University of California, San Diego. "With the knowledge of how DNA folds inside the nucleus, we now have a more complete picture of the regulatory process of genes. That is the primary reason we sought to tackle this problem." The spatial organization is intimately linked to its role in the body.

Ludwig researchers used a sequencing-based method called Hi-C to examine the 3-D structure of chromosomes. "With this technology, we were able to build a map of pair-wise interactions from each chromosome, and from that, extrapolate the basic folding pattern of the DNA. What we learned is that they fold into many local domains termed topological domains, which are on average one million base pairs in size. By way of comparison, the whole human genome is just over three
'/>"/>

Contact: Rachel Steinhardt
rsteinhardt@licr.org
212-450-1582
Ludwig Institute for Cancer Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Apelin hormone injections powerfully lower blood sugar
2. Powerful online tool for protein analysis provided pro bono by Stanford geneticist
3. Newly identified gene powerful predictor of colon cancer metastasis
4. Biologists learn structure, mechanism of powerful molecular motor in virus
5. Cancer Genomics Browser gives cancer researchers a powerful new tool
6. Collaboration leads to success: Most powerful computer of its kind in western N.Y. available worldwide
7. InVitria to Unveil Powerful Cell Culture Media Component ZAP-CHO
8. Changing climate likely to make super weed even more powerful
9. Powerful nutrient cocktail can put kids with Crohns into remission
10. Powerful new molecular GPS helps probe aging and disease processes
11. Innovative Document Security Technology Proves Powerful in Avoiding Counterfeit Products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... 2014  Leading identity analyst firm Acuity Market Intelligence ... world,s population will have a chip-based National eID card, ... . Asia , with its vast ... more than 60% of all National eID cards issued ... "The Global National eID Industry Report: 2014 ...
(Date:10/18/2014)... Berlin, 19th October 2014 Psychological stress and stress-related ... for aging-related diseases, but the molecular mechanisms ... mechanisms may contribute to the development of ... treatments for these devastating diseases. This work ... Neuropsychopharmacology congress in Berlin., Now an international ...
(Date:10/17/2014)... regarding Ebola is critical and pertinent for practicing physicians ... outbreak and epidemic. The Journal, Disaster Medicine and ... Ebola Virus and Public Health, to surround the public, ... critical societal moment. , On October 17, the ... . The primer was prepared by Dr. Eric Toner, ...
Breaking Biology News(10 mins):Half the World's Population Will Have Chip-Based National Electronic Identity (eID) Cards by 2018 2Researchers find why depression and aging linked to increased disease risk 2
... that has shown promise in skin disease and hemophilia might ... a new study by researchers at Stanford University School of ... in the Proceedings of the National Academy of Sciences the ... introduce a healthy copy of the gene dystrophin into mice ...
... the process that controls plant growth may help explain ... international team of scientists. , ,Researchers from Purdue ... the first time that proteins similar to multi-drug resistant ... cells, said Purdue plant cell biologist Angus Murphy. Because ...
... Although researchers over recent years have established a foothold ... by which it might contribute to aging and lifespan ... researchers studying p53 function in fruit flies show new ... a guardian against tumor formation, normal levels of p53 ...
Cached Biology News:Gene therapy for muscular dystrophy fixes frail muscle cells in animal model, Stanford study finds 2Gene therapy for muscular dystrophy fixes frail muscle cells in animal model, Stanford study finds 3Plant gene related to cancer treatment may foster new oncology drugs 2Plant gene related to cancer treatment may foster new oncology drugs 3New clues to the dark side of a key anti-tumor guardian 2
(Date:10/22/2014)... and HONG KONG , ... rare disease therapeutics enterprise, announced today that rare disease ... company as vice president, research. Dr. McKew brings more ... key leadership positions at the National Institutes of Health, ... acquisition by Wyeth). Dr. McKew will lead aTyr,s efforts to ...
(Date:10/20/2014)... Calif. , Oct. 20, 2014 ... that the Company has signed a Notice of ... Regenerative Medicine (CIRM), effective October 1, 2014.  The ... Development payments and the release of additional grant ... CIRM grant award for clinical development of Asterias, ...
(Date:10/20/2014)... PureTech , a science and ... problems, announced today the closing of a $55 ... Invesco Perpetual, a $120 Billion group of funds. ... existing pipeline forward and to advance new healthcare ... creativity to really go for the big ideas ...
(Date:10/19/2014)... October 19, 2014 The Latin American ... market in Latin America with analysis and forecast of ... 2013, and is expected to reach $2,366.8 million by ... 2018. , Browse through the TOC of the Latin ... of the in-depth analysis provided. It also provides a ...
Breaking Biology Technology:aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 4PureTech Announces Expansion with Oversubscribed $55M Funding Round 2PureTech Announces Expansion with Oversubscribed $55M Funding Round 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 4PureTech Announces Expansion with Oversubscribed $55M Funding Round 5PureTech Announces Expansion with Oversubscribed $55M Funding Round 6The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 3
... GAITHERSBURG, Md., Aug. 25 GenVec, Inc. (Nasdaq: ... 2 Small Business Innovation and Research (SBIR) grant from the National ... of Health (NIH) to support the development of GenVec,s vector production ... 2 0081205/DC50112LOGO ) , , ...
... WAYNE, Pa., Aug. 24 Encorium Group, Inc. (Nasdaq: ... (CRO) that provides design, development, and management capabilities for clinical ... pharmaceutical companies, today announced its financial results for the second ... As previously announced, on July 16, 2009 the Company sold ...
... , JACKSONVILLE, Fla., Aug. 24 In response ... to deploy social networking tools for their members or constituents, ... the Engageon Association Builder (EAB). The first launch was developed ... at www . lipid.org . ...
Cached Biology Technology:GenVec Receives an Approximately $2.5 Million Grant to Support Novel Cell Line Development 2Encorium Reports Second Quarter 2009 Financial Results 2Encorium Reports Second Quarter 2009 Financial Results 3Encorium Reports Second Quarter 2009 Financial Results 4Encorium Reports Second Quarter 2009 Financial Results 5Encorium Reports Second Quarter 2009 Financial Results 6Encorium Reports Second Quarter 2009 Financial Results 7Encorium Reports Second Quarter 2009 Financial Results 8Encorium Reports Second Quarter 2009 Financial Results 9Engageon Releases First Peer-to-Peer Medical Association Social Network 2
... S2 cells are used for heterologous protein ... (DES). The S2 cell line was derived ... hours old) Drosophila melanogaster embryos (1). ... room temperature without CO2 and is easily adapted ...
... PHD2000 syringe pump series combines Harvard Apparatuss best ... and a wide range of configuration options. A ... dimensions of syringes from all the major manufacturers. ... all the pertinent information from across the lab. ...
... For our novel expression vectors, we in-troduced ... dual controls: (i) at tran-scriptional level at the ... replication level by amplifying the plasmid copy number, ... is that it retains practically all of the ...
... This CLS number is a new ... product number. If showing no availability yet, ... (C6421) or contact customer service for assistance. ... Comp Dim: surface area 21 cm ...
Biology Products: