Navigation Links
Powerful online tool for protein analysis provided pro bono by Stanford geneticist
Date:12/1/2008

ecule, from the standpoint of its biological activity, than on other, less-critical regions of that protein," Sidow said. If a change interferes with a protein's function, the hapless creature harboring this variant dies out; if not, the creature is fruitful and multiplies, and the variant protein persists in modern species.

It's by no means obvious just from looking at a protein's linear amino-acid sequence which regions are the "business districts" of the protein, and which are the sleepier bedroom communities. However, ProPhylER shows biologists which parts of a protein are key to its activity by comparing numerous versions of the same protein from different species. This is especially useful for proteins about which nothing or little is known, which is still the majority of proteins encoded in the human genome.

Human geneticists, too, will benefit from ProPhylER (a play on words derived from the bulkier term "PROtein PHYLogenetics and Evolutionary Rates"). Each of us carries tens of thousands of protein variants (due to mutations that have persisted in the human gene pool), some fraction of which affect protein function. For researchers, it is notoriously difficult to measure experimentally how much a protein's function is impaired by a mutation. ProPhylER provides specific predictions, also based on evolutionary variation, of the impact of a mutation on the protein's function. A mutation in an amino acid that has changed a lot in evolution is much less likely to be bad than a mutation that affects an amino acid in which evolution has not tolerated any change. "This type of analysis will be key in the interpretation of your personal genome sequence, when not if that becomes commonplace," said Sidow.

After a user has searched for his or her protein of interest, the ProPhylER Web site displays data via two interfaces. The first displays all the evolutionary data graphically along the length of the protein. The second, called "Crystal P
'/>"/>

Contact: Bruce Goldman
goldmanb@stanford.edu
650-725-2106
Stanford University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Apelin hormone injections powerfully lower blood sugar
2. KAUST and IBM to build 1 of the fastest and most powerful supercomputers
3. Explorers marvel at Brittlestar City on seamount in powerful current swirling around Antarctica
4. Powerful yet reliable proteomics techniques are the focus of a new methods book
5. Gene discovery made easier with powerful new networking technique
6. There is powerful evidence of evolution in human DNA
7. Blood pressure drug telmisartan shows powerful activity against stroke
8. In the laboratory, green tea proves a powerful medicine against severe sepsis
9. Powerful integration of lipid metabolic profiling with gene expression analysis
10. Enzyme alerts cells powerful army to repair DNA damage
11. Smithsonian puts tropical eastern Pacific shore fishes online
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... NEW YORK , Dec. 23, 2014  Since its ... has helped thousands of people to eliminate the pain ... replacing the antiquated system with their own biometrics fused ... to remember usernames and passwords, Hoyos Labs , ... identity, announced today that it is offering the app ...
(Date:12/22/2014)... 22, 2014  NXT-ID, Inc. (NASDAQ: NXTD ... authentication company focused on the growing mobile commerce market, ... consultant, Apollo Robbins for the 2015 International ... Apollo Robbins will be at ... 2015, demonstrating some of his famous theft techniques to ...
(Date:12/22/2014)... DUBLIN , Dec. 22, 2014 /PRNewswire/ ... ) has announced the addition of the ... report to their offering. ... This insight provides an overview of the ... Watermarking aims to control and monitor piracy ...
Breaking Biology News(10 mins):1U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4The Global Watermarking and Fingerprinting Markets 2
... 2012 Cardium Therapeutics (NYSE Amex: CXM) today announced ... Gene & Cell Therapy (ASGCT) 15th Annual Meeting being ... in Philadelphia, PA. The new ... role in adenovector gene transfection (delivery) in mammalian hearts. ...
... a sort of giant living organism as the Gaia hypothesis ... may provide a key to answering this question. This key ... between ocean organisms, atmosphere, and land -- interactions that might ... -- first articulated by James Lovelock and Lynn Margulis in ...
... changes in air pollution were associated with changes in biomarkers ... well as measures of cardiovascular physiology in healthy young persons, ... JAMA, a theme issue on Global Health. ... (CVD), but the mechanisms by which air pollution leads to ...
Cached Biology News:Delivery of gene-therapy for heart disease boosted 100-fold; now in 100-patient trial 2UMD finding may hold key to Gaia hypothesis 2UMD finding may hold key to Gaia hypothesis 3Air pollution level changes in Beijing linked with biomarkers of cardiovascular disease 2Air pollution level changes in Beijing linked with biomarkers of cardiovascular disease 3Air pollution level changes in Beijing linked with biomarkers of cardiovascular disease 4
(Date:12/25/2014)... 2014 The report “Service ... Market by Product Type & Provider Type ... (2014-2019)” defines and segments the market with ... , Browse 152 market data tables, ... in-depth TOC on “Service Quality Management (SQM) ...
(Date:12/24/2014)... SILVER SPRING, Md. , Dec. 24, 2014 ... ) announced today that Medtronic, Inc. (NYSE: ... application to the U.S. Food and Drug Administration ... II implantable drug infusion system (including a ... Remodulin ® (treprostinil) Injection delivered intravenously to ...
(Date:12/24/2014)... and NEW YORK , Dec. 24, ... a biopharmaceutical company advancing patient care in critical areas, ... 3,500,000 shares of common stock, and warrants to purchase ... at an offering price of $4.00 per share and ... exercise price of $5.00, are exercisable immediately, and expire ...
(Date:12/24/2014)... 2014  Vermillion, Inc. (Nasdaq:   VRML), a ... today that the Company closed its previously announced ... Jack W. Schuler , Birchview Fund LLC ... million, before offering expenses.  The proceeds will be ... Under the terms of the private ...
Breaking Biology Technology:Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3
... Oct. 27 Precision Antibody(TM) has been ... the National Cancer Institute (NCI),s Clinical Proteomic Technologies for ... and standardizing the quality of monoclonal antibody reagents available ... the result of a third solicitation for contract proposals ...
... ... These products will not only provide antimicrobial protection, they are low in VOC,s (volatile ... additive chemistry is available in a wide range of RB Rubber products. , ... McMinnville, OR (PRWEB) October ...
... , NEW YORK, Oct. 26 ... research report is available in its ... Bioinformatics and Computational Biology: Bottlenecks and ... http://www.reportlinker.com/p0156561/Reportlinker-Adds-Bioinformatics-and-Computational-Biology-Bottlenecks-and-Options.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=prnewswire , The interdisciplinary ...
Cached Biology Technology:Precision Antibody Wins Contract to Develop 'Gold Standard' Antibodies as Part of National Cancer Institute's Clinical Proteomics Technologies for Cancer (CPTC) Initiative 2Precision Antibody Wins Contract to Develop 'Gold Standard' Antibodies as Part of National Cancer Institute's Clinical Proteomics Technologies for Cancer (CPTC) Initiative 3RB Rubber Introduces Environmentally Friendly Antimicrobial Rubber Flooring Products 2RB Rubber Introduces Environmentally Friendly Antimicrobial Rubber Flooring Products 3Reportlinker Adds Bioinformatics and Computational Biology: Bottlenecks and Options 2Reportlinker Adds Bioinformatics and Computational Biology: Bottlenecks and Options 3
... Polymerase is ideal for high-fidelity amplification ... such as cloning and mutagenesis. ... proprietary enzyme preparation containing recombinant DNA ... (3'Cut Site5' exonuclease) activity. Platinum ...
... PLAU N-term Antibody This antibody is generated ... synthetic peptide selected within aa 50~150 of ... in PBS with 0.09% (W/V) sodium azide. ... G column and eluted out with both ...
...
Human interferon-beta (IFN-beta). Recognizes amino acids 30-47 of IFN-beta. No cross-reactivity with Human IFN-alpha or IFN-gamma....
Biology Products: