Navigation Links
Powerful genome barcoding system reveals large-scale variation in human DNA
Date:5/31/2010

MADISON Genetic abnormalities are most often discussed in terms of differences so miniscule they are actually called "snips" changes in a single unit along the 3 billion that make up the entire string of human DNA.

"There's a whole world beyond SNPs single nucleotide polymorphisms and we've stepped into that world," says Brian Teague, a doctoral student in genetics at the University of Wisconsin-Madison. "There are much bigger changes in there."

Variation on the order of thousands to hundreds of thousands of DNA's smallest pieces large swaths varying in length or location or even showing up in reverse order appeared 4,205 times in a comparison of DNA from just four people, according to a study published May 31 in the Proceedings of the National Academy of Sciences.

Those structural differences popped into clear view through computer analysis of more than 500 linear feet of DNA molecules analyzed by the powerful genome mapping system developed over nearly two decades by David C. Schwartz, professor of chemistry and genetics at UW-Madison.

"We probably have the most comprehensive view of the human genome ever," Schwartz says. "And the variation we're seeing in the human genome is something we've known was there and important for many years, but we haven't been able to fully study it."

To get a better picture of those structural variations, Schwartz and his team developed the Optical Mapping System, a wholly new type of genome analysis that directly examines millions of individual DNA molecules.

Common systems for analyzing genomes typically chop long DNA molecules into fragments less than a couple thousand base pairs long and multiply them en masse, like a copy machine, to develop a chemical profile of each piece.

Reading such small sections without seeing their place in the larger picture of DNA leaves out critical understanding. To make matters worse, interesting parts of the human geno
'/>"/>

Contact: David C. Schwartz
dcschwartz@wisc.edu
608-265-0546
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Enzyme alerts cells powerful army to repair DNA damage
2. Powerful integration of lipid metabolic profiling with gene expression analysis
3. In the laboratory, green tea proves a powerful medicine against severe sepsis
4. Blood pressure drug telmisartan shows powerful activity against stroke
5. There is powerful evidence of evolution in human DNA
6. Gene discovery made easier with powerful new networking technique
7. Powerful yet reliable proteomics techniques are the focus of a new methods book
8. Explorers marvel at Brittlestar City on seamount in powerful current swirling around Antarctica
9. KAUST and IBM to build 1 of the fastest and most powerful supercomputers
10. Apelin hormone injections powerfully lower blood sugar
11. Powerful online tool for protein analysis provided pro bono by Stanford geneticist
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)...  In the 2014 fiscal year, irs.gov recorded over ... figure accounts for a fraction of the estimated losses ... exceeds $11 billion globally. The polygraph has traditionally been ... occurred. Investor Mark Saint Juste along with ... partnered to administer the test in a new ...
(Date:3/20/2015)... and Markets ( http://www.researchandmarkets.com/research/rswjb4/hand_geometry ) has announced the ... Report" report to their offering. This report ... The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... Annual estimates and forecasts are provided for the period ...
(Date:3/19/2015)... 19, 2015  NXT-ID, Inc. (NASDAQ: NXTD ) ... the growing mobile commerce market, announces its biometric payment technology, ... that aired this week on Washington DC,s ... In a segment "The Next Great Thing", host Laura ... to pay, and ,a really big breakthrough in mobile payment.,  ...
Breaking Biology News(10 mins):Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 2NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 3
... have wondered why ovarian cancer cells are so attracted ... hope that such an understanding could lead to better ... series of experiments suggest a two-step model of omental ... and lodge within immune cell-containing structures known as milky ...
... 2013 http://www.researchandmarkets.com/research/xmlpcb/siliconbased has ... Sensors - Global Strategic Business Report " report ... This report analyzes the worldwide markets ... Million by the following Types: Swipe Sensors and ...
... team led by William Fenical at Scripps Institution of ... chemical compound from an ocean microbe in a preliminary ... for new treatments for anthrax and other ailments such ... reported in the international edition of the German journal ...
Cached Biology News:Ovarian cancer metastases influenced by factors in target tissues 2Ovarian cancer metastases influenced by factors in target tissues 3Silicon-based Fingerprint Sensors - Global Strategic Business Report 2Silicon-based Fingerprint Sensors - Global Strategic Business Report 3Compound discovered at sea shows potency against anthrax 2
(Date:4/16/2015)... (PRWEB) April 16, 2015 Proove ... Buzz of BIO Contest for the 2015 ... (BIO), the 2015 BIO International Convention will take place ... Pennsylvania. During the Buzz of BIO contest, industry leaders ... see present at the conference. The community voting period ...
(Date:4/16/2015)... (PRWEB) April 16, 2015 ... at Charlotte (UNC Charlotte) spin-out company, announced today ... Cooper, Ph.D., M.D., as Chief Operating Officer (COO). ... of experience in developing clinical diagnostic and biotechnology ... infectious disease. , Cooper’s extensive career transcends the ...
(Date:4/16/2015)... ROCKVILLE, Md. , April 16, 2015 /PRNewswire/ ... "RegeneRx") today announced its U.S. joint venture with ... conduct a phase 3 clinical trial for the ... dose-response, confirmatory trial for dry eye syndrome (DES) ... ReGenTree,s preservative-free eye drops, RGN-259/GBT201, this year.  Each ...
(Date:4/16/2015)... , April 16, 2015  AnaptysBio, Inc., ... of therapeutic antibodies, today announced the advancement ... program into IND-enabling studies. The Company,s anti-IL-36R ... treatment for generalized pustular psoriasis (GPP), an ... medical need. ANB019 is wholly owned within AnaptysBio,s ...
Breaking Biology Technology:Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 2Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 3OncoTAb Names Dr. David L. Cooper as COO 2RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 2RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 3RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 4RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 5AnaptysBio Advances First-In-Class Anti-IL-36 Receptor Antibody Program To Treat Orphan Inflammatory Disease 2
... Inc. (Nasdaq: TSRX ) announced today that Jeffrey ... will participate in a panel discussion on antibiotic drug development ... to Kill Superbugs: Novel Antibiotics to Hit Drug Resistant Bacteria, ... 5th at the Westin Waterfront Hotel in Boston. ...
... (Nasdaq: OREX ), a biopharmaceutical company focused ... of its upcoming Contrave® (naltrexone sustained release (SR)/bupropion SR) ... of The Obesity Society. This meeting will be held ... October 10:  Embargo Lifts October 10 at 12:30 p.m. ...
... - OncoGenex Pharmaceuticals, Inc. (NASDAQ: OGXI ) announced ... Annual BIO Investor Forum on Wednesday, October 6 at 10:30 ... Live webcasts from this conference will be available ... at http://ir.oncogenex.com . Webcast replays will be available approximately ...
Cached Biology Technology:Orexigen® Therapeutics Announces Upcoming Data Presentations at the 28th Annual Scientific Meeting of The Obesity Society 2OncoGenex Pharmaceuticals to Present at the 9th Annual BIO Investor Forum 2
Form: Ready to use Applications: Western Blot, ELISA...
This kit only detects beta-galactosidase activity at pH 6 in cultured cells andtissue sections. Beta-galactosidase activity at pH 6 ispresent only in senescent cells, and is not found inpresenescent...
For the quantitative determination of cyclic AMP (cAMP) concentrations in cell culture supernates, serum, plasma, saliva, urine and cell lysates....
FRACTALKINE [Human] (Recombinant)...
Biology Products: