Navigation Links
Pourquie Lab demonstrates role of growth factor in vertebrae formation
Date:10/30/2007

The Stowers Institutes Pourqui Lab has demonstrated the role of fibroblast growth factor (FGF) in the embryonic process of somitogenesis, an event required for vertebrae formation, in a paper posted to the Web site of the journal Development. The paper will appear in the November print issue of the journal.

The Pourqui Lab has long studied the formation of vertebrae, and the lab team has made significant contributions to the currently accepted clock and wavefront explanation of somitogenesis. The theory suggests that a periodic mechanism the segmentation clock oscillator interacts with a molecular wavefront of differentiation, converts information from the clock into positional information, and allows for the formation of vertebrae precursors known as somites.

In this paper, the team successfully characterized and verified the proposed role of FGF signaling during somitogenesis using a mouse lacking the FGF receptor Fgfr1. They also published two important secondary findings related to FGF signaling: 1) FGF controls the clock, since the cyclic genes of all pathways (WNT, NOTCH, and FGF) eventually lose their dynamic expression; and 2) by pharmacological inhibition of FGF signaling, they identified a signaling hierarchy controlling clock oscillations downstream of FGF signaling.

These findings show that both signaling pathways implicated in setting the wavefront, FGF and WNT, are also necessary for the function of the segmentation clock, said Matthias Wahl, Ph.D., Postdoctoral Research Associate and first author on the paper. This understanding opens the door to exciting new projects. Thanks to the characterization of the Fgfr1 mouse mutant, we will be able to generate genetic crosses with null mutants for other signaling pathways involved in somitogenesis and characterize genetically the interplay between the signaling pathways.

A number of genetic diseases, including congenital scoliosis, result from problems in somitogenesis and segmentation during embryogenesis, said Olivier Pourqui, Ph.D., Investigator and senior author on the paper. We believe that any new insight into the process of somitogenesis will improve understanding of the disease process and may eventually lead to a treatment for these devastating diseases. We are excited to continue studying these pathways and their implications on somitogenesis.


'/>"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Related biology news :

1. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
2. MRSA study demonstrates need for frequent hand washing and environmental disinfection in health care settings
3. Sangamo BioSciences demonstrates its ZFP treatment protects cells from HIV infection
4. New research demonstrates bone-marrow derived stem cells can reverse genetic kidney disease
5. Xie Lab demonstrates the role of microRNA pathway
6. Growth in the sea comes down to a struggle for iron
7. Plants, animals share molecular growth mechanisms
8. U-M scientists find genes that control growth of common skin cancer
9. Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems
10. Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells
11. Researchers discover chemical compounds that affect plant growth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... 18, 2017 MedNet Solutions , ... the entire spectrum of clinical research, is proud ... year for the organization in terms of corporate ... eClinical products and services. The company,s exceptional achievements ... of iMedNet ™ ...
(Date:1/12/2017)... Jan. 12, 2017  New research undertaken by Fit ... the future.  1,000 participants were simply asked which office technology ... we may consider standard issue.  Insights on what will ... also gathered from futurists and industry leaders including Penelope ... Canton .  Some of these findings ...
(Date:1/11/2017)... Jan. 11, 2017  Michael Johnson, co-founder of Visikol Inc. a ... Inc., has been named to the elite "Forbes 30 Under 30" ... of 600 people in 20 fields nationwide to be recognized as ... 15,000 applicants were selected. ... He is currently a PhD candidate at Rutgers University. ...
Breaking Biology News(10 mins):
(Date:1/18/2017)... ... January 18, 2017 , ... Announced ... Manufacturing Innovation Institutes (MII). U.S. Secretary of Commerce Penny Pritzker has announced the ... the Department of Defense has announced the award of a new Advanced Regenerative ...
(Date:1/18/2017)... York, NY (PRWEB) , ... January 18, 2017 , ... Researchers from a new ... (PSA) do not fall low enough after prostate cancer treatment, this indicates there is still ... man’s risk of mortality. , “ The PSA test has always been an indicator of ...
(Date:1/18/2017)... IL (PRWEB) , ... January 18, 2017 , ... ... on January 24th, 2017, to sell research and genetic testing lab equipment from ... service in the Northwest and Northeast regions of the United States. This 1-day ...
(Date:1/18/2017)... Philadelphia, PA (PRWEB) , ... January 18, 2017 , ... ... million in tax credits by the Pennsylvania Department of Community and Economic Development in ... 36 companies are located in the University City Keystone Innovation Zone and represent the ...
Breaking Biology Technology: