Navigation Links
Pourquie Lab demonstrates role of growth factor in vertebrae formation
Date:10/30/2007

The Stowers Institutes Pourqui Lab has demonstrated the role of fibroblast growth factor (FGF) in the embryonic process of somitogenesis, an event required for vertebrae formation, in a paper posted to the Web site of the journal Development. The paper will appear in the November print issue of the journal.

The Pourqui Lab has long studied the formation of vertebrae, and the lab team has made significant contributions to the currently accepted clock and wavefront explanation of somitogenesis. The theory suggests that a periodic mechanism the segmentation clock oscillator interacts with a molecular wavefront of differentiation, converts information from the clock into positional information, and allows for the formation of vertebrae precursors known as somites.

In this paper, the team successfully characterized and verified the proposed role of FGF signaling during somitogenesis using a mouse lacking the FGF receptor Fgfr1. They also published two important secondary findings related to FGF signaling: 1) FGF controls the clock, since the cyclic genes of all pathways (WNT, NOTCH, and FGF) eventually lose their dynamic expression; and 2) by pharmacological inhibition of FGF signaling, they identified a signaling hierarchy controlling clock oscillations downstream of FGF signaling.

These findings show that both signaling pathways implicated in setting the wavefront, FGF and WNT, are also necessary for the function of the segmentation clock, said Matthias Wahl, Ph.D., Postdoctoral Research Associate and first author on the paper. This understanding opens the door to exciting new projects. Thanks to the characterization of the Fgfr1 mouse mutant, we will be able to generate genetic crosses with null mutants for other signaling pathways involved in somitogenesis and characterize genetically the interplay between the signaling pathways.

A number of genetic diseases, including congenital scoliosis, result from problems in somitogenesis and segmentation during embryogenesis, said Olivier Pourqui, Ph.D., Investigator and senior author on the paper. We believe that any new insight into the process of somitogenesis will improve understanding of the disease process and may eventually lead to a treatment for these devastating diseases. We are excited to continue studying these pathways and their implications on somitogenesis.


'/>"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Related biology news :

1. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
2. MRSA study demonstrates need for frequent hand washing and environmental disinfection in health care settings
3. Sangamo BioSciences demonstrates its ZFP treatment protects cells from HIV infection
4. New research demonstrates bone-marrow derived stem cells can reverse genetic kidney disease
5. Xie Lab demonstrates the role of microRNA pathway
6. Growth in the sea comes down to a struggle for iron
7. Plants, animals share molecular growth mechanisms
8. U-M scientists find genes that control growth of common skin cancer
9. Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems
10. Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells
11. Researchers discover chemical compounds that affect plant growth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/10/2016)... BELL, Pa. , March 10, 2016   Unisys ... U.S. Customs and Border Protection (CBP) is testing its ... San Diego to help identify certain ... States . The test, designed to help determine the ... pedestrian environment, began in February and will run until May ...
(Date:3/9/2016)... GARDENS, Fla. , March 9, 2016 /PRNewswire/ ... management authentication and enrollment solutions, today announced the ... DigitalPersona ® Altus multi-factor authentication platform. ... and InfoSec managers to step-up security where it,s ... Washington, DC . ...
(Date:3/3/2016)... March 3, 2016  2016FLEX, organized by FlexTech, ... highlighting advancements in flexible, hybrid and printed electronics. ... attendance - have gathered for short courses, technical ... of electronics. The Flex Conference celebrates its 15 ... companies, R&D organizations, and universities contributing to the ...
Breaking Biology News(10 mins):
(Date:5/19/2016)... ... May 19, 2016 , ... Anton Paar USA, located in Ashland, ... building is complete. The new structure adds a third office building to the current ... purchased 2.4 acres of land, along with office space adjacent to the previous ...
(Date:5/19/2016)... KS (PRWEB) , ... May 19, 2016 , ... ... contract research organization (CRO) has welcomed Abu Siddiqui as Director, Large Molecule & ... and executing biologics, vaccine and translational biomarker discovery studies for preclinical and clinical ...
(Date:5/18/2016)... ... 18, 2016 , ... Tech Coast Angels (TCA) today announced that ... at the annual ACA Summit last week in Philadelphia. , The award ... member angel groups. It is the highest honor available for an early-stage company to ...
(Date:5/18/2016)... ... 18, 2016 , ... STACS DNA Inc., the sample tracking software company, today ... assault kit processing to help them save time and reduce errors. , Sexual Assault ... be processed and victims informed of results. Due to a previous lack of tools, ...
Breaking Biology Technology: