Navigation Links
Pourquie Lab demonstrates role of growth factor in vertebrae formation
Date:10/30/2007

The Stowers Institutes Pourqui Lab has demonstrated the role of fibroblast growth factor (FGF) in the embryonic process of somitogenesis, an event required for vertebrae formation, in a paper posted to the Web site of the journal Development. The paper will appear in the November print issue of the journal.

The Pourqui Lab has long studied the formation of vertebrae, and the lab team has made significant contributions to the currently accepted clock and wavefront explanation of somitogenesis. The theory suggests that a periodic mechanism the segmentation clock oscillator interacts with a molecular wavefront of differentiation, converts information from the clock into positional information, and allows for the formation of vertebrae precursors known as somites.

In this paper, the team successfully characterized and verified the proposed role of FGF signaling during somitogenesis using a mouse lacking the FGF receptor Fgfr1. They also published two important secondary findings related to FGF signaling: 1) FGF controls the clock, since the cyclic genes of all pathways (WNT, NOTCH, and FGF) eventually lose their dynamic expression; and 2) by pharmacological inhibition of FGF signaling, they identified a signaling hierarchy controlling clock oscillations downstream of FGF signaling.

These findings show that both signaling pathways implicated in setting the wavefront, FGF and WNT, are also necessary for the function of the segmentation clock, said Matthias Wahl, Ph.D., Postdoctoral Research Associate and first author on the paper. This understanding opens the door to exciting new projects. Thanks to the characterization of the Fgfr1 mouse mutant, we will be able to generate genetic crosses with null mutants for other signaling pathways involved in somitogenesis and characterize genetically the interplay between the signaling pathways.

A number of genetic diseases, including congenital scoliosis, result from problems in somitogenesis and segmentation during embryogenesis, said Olivier Pourqui, Ph.D., Investigator and senior author on the paper. We believe that any new insight into the process of somitogenesis will improve understanding of the disease process and may eventually lead to a treatment for these devastating diseases. We are excited to continue studying these pathways and their implications on somitogenesis.


'/>"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Related biology news :

1. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
2. MRSA study demonstrates need for frequent hand washing and environmental disinfection in health care settings
3. Sangamo BioSciences demonstrates its ZFP treatment protects cells from HIV infection
4. New research demonstrates bone-marrow derived stem cells can reverse genetic kidney disease
5. Xie Lab demonstrates the role of microRNA pathway
6. Growth in the sea comes down to a struggle for iron
7. Plants, animals share molecular growth mechanisms
8. U-M scientists find genes that control growth of common skin cancer
9. Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems
10. Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells
11. Researchers discover chemical compounds that affect plant growth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/3/2020)... ... , ... Brilliant , the leading smart home control and lighting company, ... for purchase in the U.S., Canada, and Puerto Rico through ADI Global Distribution, a ... to being available for purchase through ADI’s Digital Branch , Brilliant products are ...
(Date:9/3/2020)... ... September 03, 2020 , ... Litmus Health ... extensive third-party assessment of the company’s security practices has been completed. The assessment ... regulations. The comprehensive evaluation reviewed Litmus’ processes and systems, assessing them to see ...
(Date:8/26/2020)... SHANGHAI (PRWEB) , ... August 24, 2020 , ... ... approaches for the treatment of chronic inflammatory and fibrotic diseases, today announced that ... Vice President of Drug Discovery. , Dr. Canan previously served as Executive Director ...
Breaking Biology News(10 mins):
(Date:9/3/2020)... ... September 03, 2020 , ... The ... speakers to present updates on their latest research and technology in the areas ... impact in clinical diagnostics and therapeutic development, as well as the evolving view ...
(Date:9/1/2020)... ... September 01, 2020 , ... Slone Partners , a ... the placement of Julianne Averill , CPA, as Chief Financial Officer at ... and implementing key business strategies to accelerate Alveo’s growth as the company advances ...
(Date:8/31/2020)... ... August 29, 2020 , ... DuPont ... capability in Wuxi, China. The new plant operation will provide the local animal ... technology. , “This facility will improve the flexibility of our offerings to ...
(Date:8/15/2020)... PORTLAND, Ore. (PRWEB) , ... August 13, 2020 , ... ... announced the creation of its Scientific Advisory Board (SAB) to research the medical ... medical cannabis can be enhanced when combined with terpenes. The board is focused on ...
Breaking Biology Technology: