Navigation Links
Pourquié lab links beta-catenin gradient to process of somite formation
Date:12/27/2007

The Stowers Institutes Pourqui Lab has demonstrated the importance of Beta-catenin, a key component of the Wnt-signaling pathway in the process of somite formation. The work has been published on the Web site of Nature Cell Biology and will appear in a future print issued. It was conducted using a novel real-time imaging technology.

The team analyzed the somite segmentation process that results in the formation of the vertebral column. This process is thought to be controlled by two components: a molecular oscillator (the segmentation clock), and the graded activity of several major signaling pathways (the gradient) in the presomitic mesoderm (PSM). The PSM is the middle layer of the three cell layers that form an early embryo. Wnt-signaling has been implicated in both these mechanisms, but precisely how was unclear until now.

In this work, the Pourqui team tested the importance of Beta-catenin, a protein that functions as the principal mediator of the Wnt-signaling pathway, in the process of somite formation. They showed that a newly identified Beta-catenin protein gradient in the PSM is critical in regulating mesoderm maturation. Real-time imaging experiments also demonstrated that, conversely, the segmentation clock is not caused by graded levels of Beta-catenin protein.

We were able to demonstrate that increasing Beta-catenin protein levels dramatically alters PSM maturation, said Alexander Aulehla, M.D., Senior Research Associate and first author on the paper. But, by using the real-time imaging technique in mouse embryos, we could show that increasing Beta-catenin also corresponded with ongoing, even ectopic, oscillations of the segmentation clock, which controls the rate of somite development.

This work offers novel insights into how the mechanisms of maturation and oscillation in the PSM are controlled and how they are interconnected, said Olivier Pourqui, Ph.D., Investigator and senior author on the paper. Additionally, this project has allowed us to achieve the longstanding goal of visualizing the segmentation clock in real-time using fluorescence-based imaging, which is sure to impact other important projects in our lab

Since joining the Stowers Institute in 2002, the Pourqui Lab has made a number of significant discoveries related to somite development. Somites eventually give rise to the vertebral column, which is malformed in people born with congenital scoliosis. It is believed that some cases of congenital scoliosis are caused by mutations related to the segmentation clock.


'/>"/>
Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Related biology news :

1. Study links cat disease to flame retardants in furniture and to pet food
2. Cholesterol metabolism links early- and late-onset Alzheimers disease
3. MIT links gene to cholesterol
4. Insulins brain impact links drugs and diabetes
5. Wireless Public Safety Solution From BIO-key(R) and DaProSystems Links Virginia Law Enforcement Agencies
6. Study links success of invasive Argentine ants to diet shifts
7. Thermochemical process converts poultry litter into bio-oil
8. New insight into the mechanisms of voltage sensing and transduction in biological processes
9. UCI researchers restore memory process in most common form of mental disability
10. ACT Ensures Integrity of Testing Process Through Deployment of BIO-keys(R) Biometric ID Technology
11. Engineered weathering process could mitigate global warming
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/9/2016)... , June 9, 2016  Perkotek an innovation leader in attendance control systems ... seamlessly log work hours, for employers to make sure the right employees are actually ... http://photos.prnewswire.com/prnh/20160609/377486LOGO ... ... ...
(Date:6/3/2016)... LONDON , June 3, 2016 /PRNewswire/ ... Transport Management) von Nepal ... ,Angebot und Lieferung hochsicherer geprägter Kennzeichen, einschließlich ... weltweit führend in der Produktion und Implementierung ... an der Ausschreibung im Januar teilgenommen, aber ...
(Date:6/2/2016)... 2016 Perimeter Surveillance & Detection ... Physical Infrastructure, Support & Other Service  The ... offers comprehensive analysis of the global Border Security ... revenues of $17.98 billion in 2016. Now: ... leader in software and hardware technologies for advanced video ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... DIEGO , June 24, 2016 ... more sensitively detects cancers susceptible to PARP inhibitors ... circulating tumor cells (CTCs). The new test has ... HRD-targeted therapeutics in multiple cancer types. ... targeting DNA damage response pathways, including PARP, ATM, ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced ... this eBook by providing practical tips, tools, and strategies for clinical researchers. , ...
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT ... Ontario biotechnology company, Propellon Therapeutics ... development and commercialization of a portfolio of first-in-class ... Epigenetic targets such as WDR5 represent an exciting ... significantly in precision medicine for cancer patients. Substantial ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, Inc. is pleased ... received AOAC Research Institute approval 061601. , “This is another AOAC-RI approval of ... Salter, Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods perform ...
Breaking Biology Technology: