Navigation Links
Pourquié lab links beta-catenin gradient to process of somite formation

The Stowers Institutes Pourqui Lab has demonstrated the importance of Beta-catenin, a key component of the Wnt-signaling pathway in the process of somite formation. The work has been published on the Web site of Nature Cell Biology and will appear in a future print issued. It was conducted using a novel real-time imaging technology.

The team analyzed the somite segmentation process that results in the formation of the vertebral column. This process is thought to be controlled by two components: a molecular oscillator (the segmentation clock), and the graded activity of several major signaling pathways (the gradient) in the presomitic mesoderm (PSM). The PSM is the middle layer of the three cell layers that form an early embryo. Wnt-signaling has been implicated in both these mechanisms, but precisely how was unclear until now.

In this work, the Pourqui team tested the importance of Beta-catenin, a protein that functions as the principal mediator of the Wnt-signaling pathway, in the process of somite formation. They showed that a newly identified Beta-catenin protein gradient in the PSM is critical in regulating mesoderm maturation. Real-time imaging experiments also demonstrated that, conversely, the segmentation clock is not caused by graded levels of Beta-catenin protein.

We were able to demonstrate that increasing Beta-catenin protein levels dramatically alters PSM maturation, said Alexander Aulehla, M.D., Senior Research Associate and first author on the paper. But, by using the real-time imaging technique in mouse embryos, we could show that increasing Beta-catenin also corresponded with ongoing, even ectopic, oscillations of the segmentation clock, which controls the rate of somite development.

This work offers novel insights into how the mechanisms of maturation and oscillation in the PSM are controlled and how they are interconnected, said Olivier Pourqui, Ph.D., Investigator and senior author on the paper. Additionally, this project has allowed us to achieve the longstanding goal of visualizing the segmentation clock in real-time using fluorescence-based imaging, which is sure to impact other important projects in our lab

Since joining the Stowers Institute in 2002, the Pourqui Lab has made a number of significant discoveries related to somite development. Somites eventually give rise to the vertebral column, which is malformed in people born with congenital scoliosis. It is believed that some cases of congenital scoliosis are caused by mutations related to the segmentation clock.

Contact: Marie Jennings
Stowers Institute for Medical Research

Related biology news :

1. Study links cat disease to flame retardants in furniture and to pet food
2. Cholesterol metabolism links early- and late-onset Alzheimers disease
3. MIT links gene to cholesterol
4. Insulins brain impact links drugs and diabetes
5. Wireless Public Safety Solution From BIO-key(R) and DaProSystems Links Virginia Law Enforcement Agencies
6. Study links success of invasive Argentine ants to diet shifts
7. Thermochemical process converts poultry litter into bio-oil
8. New insight into the mechanisms of voltage sensing and transduction in biological processes
9. UCI researchers restore memory process in most common form of mental disability
10. ACT Ensures Integrity of Testing Process Through Deployment of BIO-keys(R) Biometric ID Technology
11. Engineered weathering process could mitigate global warming
Post Your Comments:
(Date:6/23/2017)... N.Y. , June 23, 2017  IBM (NYSE: ... dairy research, today announced a new collaboration using next-generation ... chances that the global milk supply is impacted by ... Cornell University has become the newest academic institution to ... a food safety initiative that includes IBM Research, Mars, ...
(Date:5/6/2017)... , May 5, 2017 ... just announced a new breakthrough in biometric authentication ... exploits quantum mechanical properties to perform biometric authentication. These ... smart semiconductor material created by Ram Group and ... finance, entertainment, transportation, supply chains and security. Ram ...
(Date:4/13/2017)... 13, 2017 UBM,s Advanced Design and Manufacturing ... feature emerging and evolving technology through its 3D Printing ... run alongside the expo portion of the event and ... demonstrations focused on trending topics within 3D printing and ... manufacturing event will take place June 13-15, 2017 at the ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... Palo Alto, CA, USA (PRWEB) , ... October 11, 2017 , ... ... is set to take place on 7th and 8th June 2018 in San Francisco, ... and policy influencers as well as several distinguished CEOs, board directors and government officials ...
(Date:10/11/2017)... -- VMS BioMarketing, a leading provider of patient support solutions, has ... (CNE) network, which will launch this week. The VMS CNEs ... professionals to enhance the patient care experience by delivering peer-to-peer ... care professionals to help women who have been diagnosed and ... ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are ... 5.5 million people each year. Especially those living in larger cities are affected by ... in one of the most pollution-affected countries globally - decided to take action. , ...
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology today ... designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) ... able to cross the cell membrane and bind intracellular STAT3 and inhibit its ...
Breaking Biology Technology: