Navigation Links
Pourquié lab links beta-catenin gradient to process of somite formation
Date:12/27/2007

The Stowers Institutes Pourqui Lab has demonstrated the importance of Beta-catenin, a key component of the Wnt-signaling pathway in the process of somite formation. The work has been published on the Web site of Nature Cell Biology and will appear in a future print issued. It was conducted using a novel real-time imaging technology.

The team analyzed the somite segmentation process that results in the formation of the vertebral column. This process is thought to be controlled by two components: a molecular oscillator (the segmentation clock), and the graded activity of several major signaling pathways (the gradient) in the presomitic mesoderm (PSM). The PSM is the middle layer of the three cell layers that form an early embryo. Wnt-signaling has been implicated in both these mechanisms, but precisely how was unclear until now.

In this work, the Pourqui team tested the importance of Beta-catenin, a protein that functions as the principal mediator of the Wnt-signaling pathway, in the process of somite formation. They showed that a newly identified Beta-catenin protein gradient in the PSM is critical in regulating mesoderm maturation. Real-time imaging experiments also demonstrated that, conversely, the segmentation clock is not caused by graded levels of Beta-catenin protein.

We were able to demonstrate that increasing Beta-catenin protein levels dramatically alters PSM maturation, said Alexander Aulehla, M.D., Senior Research Associate and first author on the paper. But, by using the real-time imaging technique in mouse embryos, we could show that increasing Beta-catenin also corresponded with ongoing, even ectopic, oscillations of the segmentation clock, which controls the rate of somite development.

This work offers novel insights into how the mechanisms of maturation and oscillation in the PSM are controlled and how they are interconnected, said Olivier Pourqui, Ph.D., Investigator and senior author on the paper. Additionally, this project has allowed us to achieve the longstanding goal of visualizing the segmentation clock in real-time using fluorescence-based imaging, which is sure to impact other important projects in our lab

Since joining the Stowers Institute in 2002, the Pourqui Lab has made a number of significant discoveries related to somite development. Somites eventually give rise to the vertebral column, which is malformed in people born with congenital scoliosis. It is believed that some cases of congenital scoliosis are caused by mutations related to the segmentation clock.


'/>"/>
Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Related biology news :

1. Study links cat disease to flame retardants in furniture and to pet food
2. Cholesterol metabolism links early- and late-onset Alzheimers disease
3. MIT links gene to cholesterol
4. Insulins brain impact links drugs and diabetes
5. Wireless Public Safety Solution From BIO-key(R) and DaProSystems Links Virginia Law Enforcement Agencies
6. Study links success of invasive Argentine ants to diet shifts
7. Thermochemical process converts poultry litter into bio-oil
8. New insight into the mechanisms of voltage sensing and transduction in biological processes
9. UCI researchers restore memory process in most common form of mental disability
10. ACT Ensures Integrity of Testing Process Through Deployment of BIO-keys(R) Biometric ID Technology
11. Engineered weathering process could mitigate global warming
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2016)... YORK , May 16, 2016   EyeLock ... solutions, today announced the opening of an IoT Center ... to strengthen and expand the development of embedded iris ... an unprecedented level of convenience and security with unmatched ... authenticate one,s identity aside from DNA. EyeLock,s platform uses ...
(Date:5/3/2016)... 3, 2016  Neurotechnology, a provider of high-precision ... Automated Biometric Identification System (ABIS) , a complete ... MegaMatcher ABIS can process multiple complex biometric transactions ... of fingerprint, face or iris biometrics. It leverages ... and MegaMatcher Accelerator , which have been ...
(Date:4/26/2016)... India and LONDON ... Infosys Finacle, part of EdgeVerve Systems, a product ... and Onegini today announced a partnership to integrate ... solutions.      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ... to provide their customers enhanced security to access ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June, 23, 2016  The Biodesign Challenge ... envision new ways to harness living systems and biotechnology, ... Art (MoMA) in New York City ... 130 participating students, showcased projects at MoMA,s Celeste Bartos ... Paola Antonelli , MoMA,s senior curator of architecture and ...
(Date:6/23/2016)... ... ... STACS DNA Inc., the sample tracking software company, today announced that Dr. ... STACS DNA as a Field Application Specialist. , “I am thrilled that Dr. ... STACS DNA. “In further expanding our capacity as a scientific integrator, Hays brings a ...
(Date:6/23/2016)... BEACH, Calif. , June 23, 2016  Blueprint ... new biological discoveries to the medical community, has closed ... co-founder Matthew Nunez . "We have ... us with the capital we need to meet our ... will essentially provide us the runway to complete validation ...
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the only ... Center and will showcase its product’s latest features from June 26 to June ... scientific poster on Disrupting Clinical Trials in The Cloud during the conference. ...
Breaking Biology Technology: