Navigation Links
Potential treatment for deadly E. coli disease
Date:6/7/2011

A potential life-saving treatment for severe E. coli food poisoning outbreaks developed more than a decade ago hasn't gone forward into clinical trials because of lack of commercial interest.

University of Adelaide researchers produced a "designer" probiotic bacterium which binds and neutralises the toxin produced by E. coli, which causes life-threatening attack on the kidneys and blood vessels.

The team of scientists Dr Adrienne Paton, Associate Professor Renato Morona and Professor James Paton showed that mice infected with a highly virulent strain of E. coli were completely protected by the probiotic bacterium.

The research was published in the prestigious journal Nature Medicine in 2000 and generated ongoing interest from the scientific and medical community but the commercial sector hasn't taken up its development for progress into clinical trials in humans.

"Severe E. coli food poisoning outbreaks such as that currently occurring in Europe are becoming increasingly common," said Professor Paton, Director, Research Centre for Infectious Diseases at the University of Adelaide.

"They have the potential to cause widespread disease and many patients develop life-threatening complications including kidney failure.

"The probiotic bacterium could be produced cheaply on a large scale. However, in spite of on-going attention from the scientific and medical community, there has been a lack of interest from the commercial sector in taking this product forward into clinical trials.

"If this had been done, and the probiotic had been proven to be safe and efficacious in humans, it could have been deployed during the current European outbreak. This would undoubtedly have saved lives, as well as millions of dollars in current and future health care costs."

The researchers engineered a harmless bacterium to mimic binding receptors for the potentially fatal Shiga toxin on its surface.

Professor Paton said after diagnosis of E. coli infection there was a window of opportunity for therapeutic intervention before kidneys started to fail. Antibiotics are not used because they can increase the amount of toxin released in the gut.


'/>"/>

Contact: Professor James Paton
james.paton@adelaide.edu.au
61-414-732-967
University of Adelaide
Source:Eurekalert

Related biology news :

1. Estimating landfill gas potential
2. CDC assesses potential human exposure to prion diseases
3. Scientists find new class of compounds with great potential for research and drug development
4. Liquid smoke from rice shows potential health benefits
5. CHOP partners with Vascular Magnetics, Inc. to pursue commercial potential of blood vessel research
6. Discovery demonstrates potential MS therapy could kill brain cells
7. GW researchers reveal 18 novel subtype-dependent genetic variants for autism spectrum disorders and identify potential genetic markers for diagnostic screening
8. Satellite tracking of sea turtles reveals potential threat posed by manmade chemicals
9. Viral replicase points to potential cancer therapy
10. School energy audits find millions in potential energy savings
11. A diabetes drug, sitagliptin, also has a potential to prevent diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2017)... Feb 10, 2017 Research and ... "Personalized Medicine - Scientific and Commercial Aspects" to ... ... Diagnosis is integrated with therapy for selection of treatment as ... detection and prevention of disease in modern medicine. Biochip/microarray technologies ...
(Date:2/8/2017)... Feb. 7, 2017 The biometrics market ... the confluence of organizations, desires to better authenticate ... systems (password and challenge questions), biometrics is quickly ... systems. The market is driven by use cases, ... consumer and enterprise uses cases, with consumer-facing use ...
(Date:2/6/2017)... 2017 According to Acuity Market Intelligence, ... authorities to continue to embrace biometric and digital ... Automated Border Control (ABC) eGates and 1436 Automated ... than 163 ports of entry across the globe. ... a combined CAGR of 37%. APC Kiosks reached ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... USA, and CARDIFF, UK (PRWEB) , ... February ... ... international society for optics and photonics , have been named Fellows of the ... significant scientific and technical contributions in the multidisciplinary fields of optics, photonics, and ...
(Date:2/22/2017)... , Feb. 22, 2017 Scientists propose ... inflammation and organ damage in Gaucher and maybe other ... risks and lower costs than current therapies. ... Hospital Medical Center , which also included investigators from ... , report their data Feb. 22. The study was ...
(Date:2/22/2017)... Dublin - Research and Markets ... (Bio-Pesticide) Market-By Type, By Application, By End User, By Region, By ... ... Protection Market is forecasted to grow at a CAGR of 11.33% ... biological crop protection market is driven by the surging demand for ...
(Date:2/22/2017)... DIEGO , Feb. 22, 2017  Creative ... expansion of its translational research program using its ... of laboratory facilities in San Diego.  The Company ... BioLabs facility, a biotechnology incubator sponsored by the ... In November 2016, the Company obtained an ...
Breaking Biology Technology: