Navigation Links
Potential therapy for congenital muscular dystrophy
Date:12/29/2008

Reno, Nevada Current research suggests laminin, a protein that helps cells stick together, may lead to enhanced muscle repair in muscular dystrophy. The related report by Rooney et al, "Laminin-111 restores regenerative capacity in a mouse model for alpha 7 integrin congenital myopathy," appears in the January 2009 issue of The American Journal of Pathology.

Muscular dystrophy is a group of inherited genetic diseases that cause progressive muscle weakness. In one type of muscular dystrophy, patients with mutations in the adhesion molecule alpha 7 integrin experience delayed developmental milestones and impaired mobility. There is currently no treatment or cure for alpha 7 integrin congenital myopathy.

Interactions of alpha 7 integrin with laminin, an extracellular protein found surrounding muscle fibers, promote muscle cell health and survival. Alpha 7 integrin has also been implicated in muscle repair. To determine if alpha 7 integrin is critical for muscle repair, researchers led by Dr. Dean Burkin at The University of Nevada School of Medicine examined the response to muscle damage in alpha 7 integrin-deficient mice. They found that alpha 7 integrin-deficient muscle exhibited defective muscular regeneration. Injection of laminin-111, however, restored muscle repair and regeneration.

The data from Rooney et al "indicate a critical role for the alpha7beta1 integrin and laminin in muscle repair and suggest direct muscle injections of laminin may serve as an exciting novel therapy for patients with alpha 7 integrin congenital myopathy and other muscle diseases." Dr. Burkin's group is "currently investigating the potential of this technology to treat Duchenne and other forms of muscular dystrophy. This work opens a whole new modality in therapeutics, of injecting extracellular matrix proteins to treat genetic diseases."


'/>"/>

Contact: Angela Colmone
acolmone@asip.org
301-634-7953
American Journal of Pathology
Source:Eurekalert

Page: 1

Related biology news :

1. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
2. Neuronal conduction of excitation without action potentials based on ceramide production
3. To maximize biofuel potential, researchers look for sorghums sweet spot
4. Joslin researchers uncover potential role of leptin in diabetes
5. Chemistry turns killer gas into potential cure
6. Researchers examine worlds potential to produce biodiesel
7. New inhibitor has potential as cancer drug
8. Potential new therapeutic molecular target to fight cancer
9. WCS study finds potential to double tiger numbers in South Asia
10. Childrens Hospital studying drug with the potential to prevent/delay onset of type 1 diabetes
11. Great potential to improve collection, recycling of Europes electronic waste, says UN report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Inc. (NASDAQ: NXTD and NXTDW) a biometric authentication company ... of the Wocket™ smart wallet at CES 2015 in Las ... one of the "11 Hot Products at CES" in a review published ... Far" by Newseveryday.com and "The top 10 gadgets from CES 2015" by ...
(Date:1/22/2015)... 21, 2015  Analyst Report Issued by Small Cap IR. In ... that planet-wide, transactions at merchants on the leading payment cards ... of credit, debit, and prepaid cards reached 6.54 billion.  Eight ... fraudulent card usage in 2012, and credit and debit card ...
(Date:1/22/2015)... , Jan. 22, 2015 Research and Markets ... addition of the "Global Wearable Technologies Market ... Share, Overview, Trends and Forecast 2014-2020" report ... Technologies are smart devices that can be worn ...
Breaking Biology News(10 mins):CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2
... RELEASE "Snow flea antifreeze protein" could help ... Society Scientists in Illinois and Pennsylvania are ... protein that enables billions of Canadian snow fleas to ... have practical uses in extending the storage life of ...
... transplants involve the use of stem cells from another ... major concern of the potential for acute graft-versus-host disease ... by the grafted cells against the recipient, resulting in ... are no definitive markers for predicting the development of ...
... remarkable way to protect their unborn pups. Because the ... and reactivate the ovulatory cycle, pregnant mice prevent the ... Researchers from the European Molecular Biology Laboratory (EMBL) in ... ability. A surge of the chemical signal dopamine in ...
Cached Biology News:American Chemical Society's Weekly PressPac -- July 16, 2008 2American Chemical Society's Weekly PressPac -- July 16, 2008 3American Chemical Society's Weekly PressPac -- July 16, 2008 4American Chemical Society's Weekly PressPac -- July 16, 2008 5American Chemical Society's Weekly PressPac -- July 16, 2008 6American Chemical Society's Weekly PressPac -- July 16, 2008 7American Chemical Society's Weekly PressPac -- July 16, 2008 8American Chemical Society's Weekly PressPac -- July 16, 2008 9Predicting acute GVHD by gene expression could improve liver stem cell transplant outcomes 2Pregnant mice block out unwelcome admirers to protect their pups 2
(Date:1/22/2015)... January 22, 2015 Shimadzu Scientific ... UV-1280 multipurpose UV-visible spectrophotometer. Offering wavelength scanning from ... is ideal for applications in a variety of ... , The user-friendly UV-1280 enables intuitive operation, while ...
(Date:1/22/2015)... Cambridge Semantics, the leading provider of smart data ... was a record-breaking year across the board for the company. ... Data Platform and our Smart Data solutions, our customers were ... which led to record growth for the company in 2014,” ...
(Date:1/22/2015)... 22, 2015 Pipette.com has added the ... their comprehensive portfolio of Eppendorf products. , The Eppendorf ... a Centrifuge 5424/5424 R and receive the following:, ... Research plus or Eppendorf Reference 2 , ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Selexis SA, ... mammalian Research Cell Banks (RCBs) used for drug discovery ... Cell Banks will include Next-Generation Sequencing (NGS) ... architecture de-risks biologic manufacturing by ensuring the integrity of ...
Breaking Biology Technology:Shimadzu’s New Monitored Single-Beam UV-Vis Spectrophotometer Offers Comprehensive Measurement Options in a Compact Body 2Cambridge Semantics Announces Record Results for 2014 2Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2
... Consumers cutting "experimental luxuries" such as expensive spa and anti-aging treatments ... hiring someone else to pamper them, they pamper themselves by re-creating ... a new spa facial line, meets this growing demand for high ... ...
... Plastics are everywhere in our modern world, largely due ... but lightweight and easily workable. One of their most ... than break when put under stress - is also ... "plastic flow", allows many plastics to change shape to ...
... BioInformatics, LLC,( http://www.gene2drug.com ) -- the leading market ... -- announces the publication of its latest,report, "The ... the,original social media study published jointly in 2007 ... and marketing agency,-- this report explores the impact ...
Cached Biology Technology:ZhenSpa.com provides Spa Enthusiasts Affordable Alternatives for Expensive Spa Treatments 2ZhenSpa.com provides Spa Enthusiasts Affordable Alternatives for Expensive Spa Treatments 3ZhenSpa.com provides Spa Enthusiasts Affordable Alternatives for Expensive Spa Treatments 4Fast molecular rearrangements hold key to plastic's toughness 2Fast molecular rearrangements hold key to plastic's toughness 3BioInformatics, LLC Studies Effective Strategies for Scientific Publishing in a Web 2.0 World 2BioInformatics, LLC Studies Effective Strategies for Scientific Publishing in a Web 2.0 World 3
Human MFRP MAb (Clone 291218)...
Human RELT/TNFRSF19L Affinity Purified Polyclonal Ab...
... The NOS assay kit measures NOS activity ... to citrulline. This assay is simple, sensitive, ... be used with both crude and purified ... and reagents for 50 total reactions. Radiolabeled ...
SNARE associated protein snapin, clone MGC:2717...
Biology Products: