Navigation Links
Potential new target for multiple sclerosis therapy
Date:3/28/2008

Researchers demonstrate both genetic and pharmaceutical evidence for the role of a protein called collagenase-2 in the development of multiple sclerosis (MS), providing a potential new way to combat this debilitating disease.

Collagenase-2 is a member of a protein family called matrix metalloproteinases (MMPs, collagenase-2 is MMP8), a large group of enzymes that break down collagen and other components of the body's connective tissue. MMPs have been implicated in contributing to MS by degrading the tissue that maintains the blood-brain barrier, thus allowing unwanted cells to invade and break down nerves. In fact, MMPs are found in elevated amounts in the blood and spinal fluid of diseased individuals.

Using a mouse model of MS, Carlos Lopez-Otin and colleagues performed two analyses on MMP8 to determine how relevant this protein is to the disease. First, they developed mutant mice deficient in the gene for MMP8 and found that these mice had a fewer invading cells in the brain, fewer damaged nerves, and a general improvement in their clinical profile.

They also gave diseased mice a drug that blocked MMP8 activity and found that this, too, could reduce the severity of disease symptoms. Taken together, these promising findings provide the first causal evidence for MMP8 in the development of MS, and offer a new therapeutic target.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1

Related biology news :

1. Changes in ocean conditions in Sargasso Sea potential cause for decline in eel fishery
2. Unexplored microbes hold incredible potential for science and industry
3. Environmental epigenetics has potential for preventing and treating disease
4. Monkey malaria widespread in humans and potentially fatal
5. Device prevents potential errors in childrens medications
6. Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal
7. New report finds great potential for Swedish medical technology
8. Great potential to improve collection, recycling of Europes electronic waste, says UN report
9. Childrens Hospital studying drug with the potential to prevent/delay onset of type 1 diabetes
10. WCS study finds potential to double tiger numbers in South Asia
11. Potential new therapeutic molecular target to fight cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2015)... ANGELES , July 27, 2015   ... evidence- and experience-based clinical improvement solutions, today announced ... solution is now available on Android smartphones and ... inpatient and post-care organizations can use ZynxCarebook to ... same patient,s condition, streamline care transitions to other ...
(Date:7/21/2015)... -- Today, ZTE announced its Android smartphone Axon, featuring ... revenues in 2015 that relate to sales of FPC1025 for this ... 2,200 MSEK for 2015. Jörgen Lantto, CEO of FPC, ... China and we are proud that ... Axon , its first ...
(Date:7/20/2015)... , July 20, 2015  Acuity Market ... Report: The Convergence of Commerce and Privacy" forecasts ... mobile biometric apps will be downloaded to smart ... The mobile biometrics market is projected to generate ... revenue during the seven-year forecast period.    ...
Breaking Biology News(10 mins):Zynx Health Adds Android Device Support to ZynxCarebook Solution 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 3FPC's Touch Fingerprint Sensor FPC1025 in ZTE's Smartphone Axon 2Biometrics on Smart Mobile Devices to Redefine Digital Identity with 12.9 Billion Biometric App Downloads between 2014 and 2020 2
... an unlikely new target: molecules. Scientists at the National ... of molecular data similar to Facebook,s recently debuted graph ... to find all their New York-living, beer-drinking buddies in ... rapidly sift through enormous chemical and biological data sets ...
... July 18, 2013 -- Scientists at Wake Forest Baptist Medical ... effect of impacts to the head incurred by football players. ... capture players, exposure to the risk of concussion over the ... magnitude of all impacts, said senior author of the study ...
... Health Summit held at the Mayflower Renaissance hotel in Washington ... to scientists, writers and researchers looking to learn and discuss ... links mushrooms to today,s and future health issues. ... world,s top scientists, researchers and nutrition experts who will provide ...
Cached Biology News:Facebook for molecules 2Facebook for molecules 3Scientists develop new way to measure cumulative effect of head hits in football 2Scientists develop new way to measure cumulative effect of head hits in football 3
(Date:7/30/2015)... 2015 AACC welcomed thousands of medical ... Annual Meeting & Clinical Lab Expo in ... meeting showcased revolutionary advancements in clinical testing technology ... providers to diagnose patients quickly and accurately and ... As of Wednesday, July 29, more ...
(Date:7/30/2015)... , July 30, 2015 ... by Product (Software, Molecular Modeling, PB/PK, PKPD, Trial Design, ... & Development, Preclinical, Clinical Trial), by End Users - ... Market is expected to reach USD 2,107.99 million by ... CAGR of 15.29%. Browse more than ...
(Date:7/30/2015)... -- With over 60,000 customers across the globe, ISN improves the efficiency and effectiveness of ... than 60,000 safe and reliable contractors in over 80 countries. ... ... Over 60,000 Worldwide Customers In More ... Headquartered in Dallas, TX , ISN has additional offices ...
(Date:7/30/2015)... ... 2015 , ... As part of its 2015 growth plan and as a follow up to ... business units, Whitehouse Laboratories is pleased to announce that it has begun construction on a ... Excellence and will be strictly dedicated to basic USP 51, USP 61, and USP 62 ...
Breaking Biology Technology:Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 2Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 3Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 4Biosimulation Market Worth 2,107.99 Million USD by 2020 2Biosimulation Market Worth 2,107.99 Million USD by 2020 3Biosimulation Market Worth 2,107.99 Million USD by 2020 4ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3Whitehouse Labs Formally Announces Plans to Open a Microbiological Laboratory 2
... Feb. 7, 2011 Tengion, Inc. (Nasdaq: TNGN ... Nichtberger, M.D., President and Chief Executive Officer of Tengion, will ... Conference on Monday, February 14, 2011, at 2:00 p.m. EST. ... "IPO Window-Creaking Open or Wide Open?" the following day on ...
... Cmed Technology , ... a roundtable and give a presentation about electronic data ... for Clinical Ops Executives ( SCOPE ) conference at ... http://photos.prnewswire.com/prnh/20100707/NY31446LOGO) As part of SCOPE,s two-day "Electronic ...
... Berkeley, have found a way to grow nanolasers directly onto ... new class of faster, more efficient microprocessors, as well as ... They describe their work in a paper to be ... journal Nature Photonics . "Our results impact ...
Cached Biology Technology:Tengion to Present at the 13th Annual BIO CEO & Investor Conference and the Leerink Swann 'Hot Topics in Therapeutics' Roundtable Conference 2Cmed Technology to Host Roundtable, Give Presentation About EDC Pain Points at Summit for Clinical Ops Executives (SCOPE) 2Cmed Technology to Host Roundtable, Give Presentation About EDC Pain Points at Summit for Clinical Ops Executives (SCOPE) 3Engineers grow nanolasers on silicon, pave way for on-chip photonics 2Engineers grow nanolasers on silicon, pave way for on-chip photonics 3
... Kit, 500 reactions. Prepare circular DNA ... h.Generate microgram quantities of template DNA ... amplified DNA directly for cycle sequencing ... M13 liquid cultures, colonies, plaques, or ...
...
Request Info...
Spaced cover glasses to promote effective hybridization...
Biology Products: