Navigation Links
Potential new target for multiple sclerosis therapy
Date:3/28/2008

Researchers demonstrate both genetic and pharmaceutical evidence for the role of a protein called collagenase-2 in the development of multiple sclerosis (MS), providing a potential new way to combat this debilitating disease.

Collagenase-2 is a member of a protein family called matrix metalloproteinases (MMPs, collagenase-2 is MMP8), a large group of enzymes that break down collagen and other components of the body's connective tissue. MMPs have been implicated in contributing to MS by degrading the tissue that maintains the blood-brain barrier, thus allowing unwanted cells to invade and break down nerves. In fact, MMPs are found in elevated amounts in the blood and spinal fluid of diseased individuals.

Using a mouse model of MS, Carlos Lopez-Otin and colleagues performed two analyses on MMP8 to determine how relevant this protein is to the disease. First, they developed mutant mice deficient in the gene for MMP8 and found that these mice had a fewer invading cells in the brain, fewer damaged nerves, and a general improvement in their clinical profile.

They also gave diseased mice a drug that blocked MMP8 activity and found that this, too, could reduce the severity of disease symptoms. Taken together, these promising findings provide the first causal evidence for MMP8 in the development of MS, and offer a new therapeutic target.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1

Related biology news :

1. Changes in ocean conditions in Sargasso Sea potential cause for decline in eel fishery
2. Unexplored microbes hold incredible potential for science and industry
3. Environmental epigenetics has potential for preventing and treating disease
4. Monkey malaria widespread in humans and potentially fatal
5. Device prevents potential errors in childrens medications
6. Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal
7. New report finds great potential for Swedish medical technology
8. Great potential to improve collection, recycling of Europes electronic waste, says UN report
9. Childrens Hospital studying drug with the potential to prevent/delay onset of type 1 diabetes
10. WCS study finds potential to double tiger numbers in South Asia
11. Potential new therapeutic molecular target to fight cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ITHACA, N.Y. , June 23, 2017 /PRNewswire/ ... leader in dairy research, today announced a new collaboration ... reduce the chances that the global milk supply is ... dairy project, Cornell University has become the newest academic ... Supply Chain, a food safety initiative that includes IBM ...
(Date:5/23/2017)... , May 23, 2017  Hunova, the first robotic gym for the ... been officially launched in Genoa, Italy . The first ... and the USA . The technology was developed ... market by the IIT spin-off Movendo Technology thanks to a 10 million ... News Release, please click: ...
(Date:5/16/2017)... , May 16, 2017   Bridge Patient ... organizations, and MD EMR Systems , an ... partner for GE, have established a partnership to ... product and the GE Centricity™ products, including Centricity ... These new integrations will allow ...
Breaking Biology News(10 mins):
(Date:8/11/2017)... Md. , Aug. 11, 2017 /PRNewswire/ ... a New York Times article regarding the ... billion, according to Kalorama Information.  The article, ... App for That"  used information from ... Patient Monitoring & Telemedicine Market  (Sleep, Diabetes, ...
(Date:8/10/2017)... ... August 09, 2017 , ... ... the agriculture industry reach its ideal customers with the right message. Their effective, ... “As a Midwest company, we realize how crucial the agriculture industry is,” said ...
(Date:8/10/2017)... ... 2017 , ... Okyanos Center for Regenerative Medicine has announced its First Annual ... Freeport, Grand Bahama on September 27, 2017. This daytime event is free to attend, ... Ministry of Health’s National Stem Cell Ethics Committee (NSCEC) and regulations laid out in ...
(Date:8/10/2017)... ... August 10, 2017 , ... ... news outlet had initiated coverage on Next Group Holdings, Inc. and see's significant ... markets geared toward those that cannot engage in traditional banking services. According to ...
Breaking Biology Technology: