Navigation Links
Potential new heart attack biomarker uncovered
Date:12/10/2009

Though they remain a leading killer, heart attacks can be effectively treated provided they can be rapidly diagnosed following initial onset of symptoms. In a study appearing in this month's Molecular and Cellular Proteomics, researchers have identified cardiac myosin-binding protein C (cMyBP-C) as a potential new diagnostic biomarker for heart attacks, one that may be particularly valuable for mild attacks in which traditional diagnostic proteins may not be abundant enough.

Currently, one of the gold-standards for diagnosis of heart attacks, or acute myocardial infarctions, is scanning for the presence of the proteins troponin I and troponin T, as they are produced specifically in the heart and are almost completely absent in the blood in healthy individuals.

However, even troponins are not ideal markers, since they are released somewhat slowly following a heart attack (peaking around 18 hours post-infarction) and remain in the blood for up to 10 days afterwards, hindering the diagnosis of any secondary heart attacks.

In the quest for better biomarkers, a group of researchers at King's College London performed a proteomic analysis of all the proteins released by mouse hearts following induced heart attacks. They identified 320 proteins not released by normal hearts, including all the currently employed biomarkers.

Only a handful of these proteins were specific to the heart, but among those, one very promising lead was cMyBP-C; within 5 minutes following a heart attack it became nearly 20 fold more abundant than before, one of the highest increases of all 320 identified proteins. In fact, cMyBP-C was abundant following even minor heart attacks, suggesting it could be very useful in such instances.

The researchers are now continuing their investigation and examining the time course of cMyBP-C release following heart attacks and its persistence in the blood of mice, to further determine this protein's poten
'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Potential cancer drug may offer new hope for asthma patients
2. New research provides insights into potential ecological costs and cobenefits of REDD
3. Interactions with aerosols boost warming potential of some gases
4. LX211 highlighted as potential disease modifying therapy for non-infectious uveitis
5. Heat forms potentially harmful substance in high-fructose corn syrup
6. Iowa State University researcher uncovers potential key to curing tuberculosis
7. Mechanism for potential Friedreichs ataxia drug uncovered
8. The vasculature emerges as a potential therapeutic target in treating ADPKD liver cysts
9. National new biology initiative offers potential for remarkable and far-reaching benefits
10. Fear of insurance rejection deters potentially life saving genetic tests for bowel cancer
11. Time to tap climate change-combating potential of the worlds ecosystems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2015)... , April 13, 2015 ... Research, "Global Biometrics Market Forecast & Opportunities, 2020", the ... CAGR of around 14% till 2020. The biometrics ... large scale implementation and review of biometric management ... of new products with greater efficiency, are resulting ...
(Date:4/10/2015)... 10, 2015 Research and Markets ... "Security Competitive Profiles - NEC" report to ... NEC will continue to supply a range of ... with a company focus on the development of a ... Winning opportunities in the Asia-Pacific ...
(Date:4/8/2015)... N.C. , April 8, 2015  Infinisource, ... solutions and services, and Morpho, a leading supplier ... partnership to produce the market,s most advanced biometrically-enabled ... Infinisource,s iSolved NXG time clock is setting a ... and labor data for the small and mid-size ...
Breaking Biology News(10 mins):Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2NEC Security Competitive Profile 2015 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3
... Deamer began studying the origin of life in the early ... had a major influence on scientific understanding of how life ... (UC Press, June 2011), Deamer presents a personal history of ... and accessible overview of research into life,s beginnings. ...
... of the 2010 Nobel Prize in Chemistry, will be ... Chemistry and Engineering Conference, June 21-23, in Washington, D.C. ... Hilton Hotel, just two blocks north of the White ... around the world, is sponsored by the American Chemical ...
... 2011) New research suggests an effective recovery drink ... Grabbing lowfat chocolate milk after a tough workout helped ... advantage, according to three new studies presented at the ... Journal of Strength and Conditioning Research this ...
Cached Biology News:Biochemist David Deamer explores how life began in new book, 'First Life' 2Nobel Laureate to speak at American Chemical Society green chemistry conference 2New research: Post-exercise recovery advantages of lowfat chocolate milk 2
(Date:5/5/2015)... , May 5, 2015  Blueprint Medicines (NASDAQ: ... its initial public offering of 9,367,708 shares of ... $18.00 per share, including shares of common stock ... of their option to purchase additional shares. The ... Blueprint Medicines were approximately $168.6 million, before underwriting discounts ...
(Date:5/5/2015)... 2015 VetStem Biopharma, proudly announces ... Jeffrey Schaffer, DVM, as Director of Veterinary Professional ... of experience in the veterinary regenerative medicine field ... our veterinarian lead organization”. Dr. Alexis Nahama, ... will be responsible for all technical activities in ...
(Date:5/5/2015)... Israel , May 5, 2015  Tikcro ... Company was approved to continue trading on OTCQB  ... OTCQB Marketplace allows for a continuous ... broker-dealers. Investors can have real-time quotes and market ... The OTCQB Marketplace includes U.S. and ...
(Date:5/5/2015)... NEW YORK , May 5, 2015 /PRNewswire/ ... today announced that Andrew Gengos , President and ... on May 7, 2015. DATE:  Thursday, May ... LINK:  http://VirtualInvestorConferences.com > click the ... will be a live, interactive online event where ...
Breaking Biology Technology:Blueprint Medicines Announces Closing of Initial Public Offering 2Leading Regenerative Veterinary Medicine Company, VetStem Biopharma announces the addition of Dr Jeffrey Schaffer as the Director of Veterinary Professional Services. 2Tikcro Technologies Announces Approval to Continue Trading on OTCQB 2ImmunoCellular Therapeutics to Webcast Live at VirtualInvestorConferences.com on May 7 2
... 11 Schering-Plough,Corporation (NYSE: SGP ) today announced ... of a New Drug Application (NDA) for ZEGERID(R),(omeprazole/sodium bicarbonate) ... a branded over-the-counter (OTC) product to treat frequent,heartburn., ... license agreement with,Santarus, Inc. of San Diego, Calif., which ...
... analysis affordable and accessible to all researchers, ... today that Harvard Medical School and the University ... Program. Each University,purchased access to whole genome human ... Consortium and distributed by Open Biosystems., (Logo: ...
... China,Bionanometer Industries Corporation (Pink Sheets: CBIU), a ... signed an agreement to,establish long-term strategic cooperative ... Guangzhou LGLY Advertising LTD is China,s top ... and is well-known for its core senior ...
Cached Biology Technology:Schering-Plough Announces Filing of U.S. Application for OTC ZEGERID(R) 2Schering-Plough Announces Filing of U.S. Application for OTC ZEGERID(R) 3Open Biosystems' Open Access RNAi Program Adopted by Harvard Medical School and University of North Carolina 2CBIU Signs Agreement with LGLY Advertising LTD 2