Navigation Links
Potential new eye tumor treatment discovered
Date:8/4/2011

Baltimore, MD New research from a team including several Carnegie scientists demonstrates that a specific small segment of RNA could play a key role in the growth of a type of malignant childhood eye tumor called retinoblastoma. The tumor is associated with mutations of a protein called Rb, or retinoblastoma protein. Dysfunctional Rb is also involved with other types of cancers, including lung, brain, breast and bone. Their work, which will be the cover story of the August 15th issue of Genes & Development, could result in a new therapeutic target for treating this rare form of cancer and potentially other cancers as well.

MicroRNAs are a short, single strands of genetic material that bind to longer strands of messenger RNA--which is the courier that brings the genetic code from the DNA in the nucleus to the cell's ribosome, where it is translated into protein. This binding activity allows microRNAs to silence the expression of select genes in a targeted manner. Abnormal versions of microRNAs have been implicated in the growth of several types of cancer.

The paper from Carnegie's Karina Conkrite, Maggie Sundby and David MacPherson--as well as authors from other institutionsfocuses on a cluster of microRNAs called miR-17~92. Recent research has shown that aberrant versions of this cluster are involved in preventing pre-cancerous cells from dying and allowing them to proliferate into tumors. Previous work has shown that miR-17~92 can be involved in the survival of lymphoma and leukemia cells by reducing the levels of a tumor-suppressing protein called PTEN.

The team's new research shows that miR-17~92 can also be involved in retinoblastoma, although it does not act in the same way, via the PTEN protein, as it does in other types of cancers. Rather, miR-17~92 acts to help cells that lack the tumor-suppressing Rb protein to proliferate.

First the team demonstrated that miR-17~92 is expressed in higher-than-usual quantiti
'/>"/>

Contact: David MacPherson
macpherson@ciwemb.edu
410-246-3084
Carnegie Institution
Source:Eurekalert

Page: 1 2

Related biology news :

1. Dissecting the genomes of crop plants to improve breeding potential
2. Researchers find potential key for unlocking biomass energy
3. Neural stem progenitor cell transplantation’s potential to aid spinal cord injury tested
4. Scientists devise way to sort brain cells for potential transplants
5. BUSM study identifies new potential approaches to treat myelofibrosis
6. Potential impact of cinnamon on multiple sclerosis studied
7. UF review of resveratrol studies confirms potential health boost
8. U-M researchers find potential new way to fight sepsis
9. Researchers discover potential cause of chronic painful skin
10. Adjuvant combo shows potential for universal influenza vaccine
11. Potential treatment for deadly E. coli disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/6/2015)... Germany , August 6, 2015 ... Instruments (SMI) shows the world,s first Eye ... on Epson,s Moverio BT-200 see-through head mounted display and ... solution, unprecedented quality and efficiency is brought to personalized ... For the first time, professionals and researchers can integrate ...
(Date:8/5/2015)... , Aug. 5, 2015 The biosensors ... growth in applications, penetration into newer sectors, and development ... The global biosensors space has seen the entry of ... market so far. (Photo - http://photos.prnewswire.com/prnh/20150805/255570 ... Sullivan, Analysis of the Global Biosensors Market ...
(Date:7/31/2015)... 2015 Den 10. internationale konference om Genomik ... 22. - 25. oktober i Shenzhen ... fødselsdag i år. Siden starten i 2006 er ICB ... ,omik,-feltet, og er en af de mest dynamiske, entusiastiske ... på nylige gennembrud og fremskridt inden for ,omik,-forskning, som ...
Breaking Biology News(10 mins):SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 3Innovative Biosensors Incite Use in Non-Traditional Applications 2Innovative Biosensors Incite Use in Non-Traditional Applications 3Innovative Biosensors Incite Use in Non-Traditional Applications 4Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2
... researchers from the National University of Singapore and the ... carotenoids to decreased hip fracture risk in elderly, lean ... In the study, the researchers examined the association between ... range of BMI in elderly Chinese men and women ...
... Favorable results have led to crizotinib gaining approval for ... cancer (NSCLC) in Japan, the United States, Canada, and ... identification of an effective therapy for ALK-positive NSCLC places ... find patients with this subtype of lung cancer. A ...
... 2012 A fast growing, flesh-eating fungus killed 5 ... according to two new studies based on genomic sequencing ... U.S. Centers for Disease Control and Prevention (CDC). ... the fungus Apophysomyces , according to the studies, ...
Cached Biology News:Study shows immunohistochemistry is reliable screening tool for ALK rearrangement 2Fungus responsible for 5 deaths in the wake of massive tornado 2Fungus responsible for 5 deaths in the wake of massive tornado 3
(Date:8/28/2015)... Brooklyn, NY (PRWEB) , ... August 28, 2015 , ... Since the initial launch of ... with their quirky humor and excellent customer service. Images such as the Fonz in ... website to add some flavor to the humdrum spectroscopy field. , FireflySci is ...
(Date:8/27/2015)... 27, 2015 /PRNewswire/ - Portage Biotech Inc. ("Portage") ... Biohaven Pharmaceutical Holding Company Limited (Biohaven), announced today ... study of BHV-0223, a glutamate modulating agent. Biohaven ... and recently obtained clearance from the U.S. Food ... testing. Portage holds 54% equity interest in Biohaven, ...
(Date:8/27/2015)... , Aug. 27, 2015 HUYA Bioscience ... meeting of the Japan Society of HTLV-1, held this ... Auditorium. The purpose of the Society is to promote ... the development of medical technology and research related to ... welfare. "HUYA is proud to support this ...
(Date:8/27/2015)... N.C. , Aug. 27, 2015 ... decision by FedEx, UPS and The US Postal ... biological specimens classified as ,select agents, by the ... history of handling these sensitive shipments. ... global transportation regulations, trained and certified personnel to ...
Breaking Biology Technology:Cuvette Manufacturer FireflySci Launches Back to School Deals with Complimentary Shipping On All Orders 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 4HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 2HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 3HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 4Marken Ensures Safe Transportation Of Select Agents And Toxins 2
... thought of as,a technology used only for computer ... technology are now being used for the,serious business ... Computing (BOINC), one of the leading distributed computing,platforms ... tap the massively parallel,processing power of NVIDIA GPUs ...
... Calif., Dec. 17 Senetek PLC,(OTC Bulletin Board: SNKTY), ... that target the science of healthy aging, today,announced that ... proposed at the Annual General Meeting of Shareholders held ... "We are pleased with the results of the ...
... 17 In a recent customer satisfaction,survey of over ... was voted by its customers as the "Top Of ... and pathologists who,subscribe to ADVANCE chose bioMerieux over other ... technical support," "reliable,instruments," and "quick response time." , ...
Cached Biology Technology:NVIDIA CUDA Technology Dramatically Advances the Pace of Scientific Research 2NVIDIA CUDA Technology Dramatically Advances the Pace of Scientific Research 3NVIDIA CUDA Technology Dramatically Advances the Pace of Scientific Research 4NVIDIA CUDA Technology Dramatically Advances the Pace of Scientific Research 5NVIDIA CUDA Technology Dramatically Advances the Pace of Scientific Research 6Senetek PLC Announces 2008 Annual General Meeting Voting Results 2Laboratory Customers Name bioMerieux 'Top Of Class' for Microbiology 2
...
...
... to CRF The antibody ... CRF sequence that it was ... are found in the paraventricular ... in colchicine treated 4% FA ...
...
Biology Products: