Navigation Links
Potential new eye tumor treatment discovered
Date:8/4/2011

Baltimore, MD New research from a team including several Carnegie scientists demonstrates that a specific small segment of RNA could play a key role in the growth of a type of malignant childhood eye tumor called retinoblastoma. The tumor is associated with mutations of a protein called Rb, or retinoblastoma protein. Dysfunctional Rb is also involved with other types of cancers, including lung, brain, breast and bone. Their work, which will be the cover story of the August 15th issue of Genes & Development, could result in a new therapeutic target for treating this rare form of cancer and potentially other cancers as well.

MicroRNAs are a short, single strands of genetic material that bind to longer strands of messenger RNA--which is the courier that brings the genetic code from the DNA in the nucleus to the cell's ribosome, where it is translated into protein. This binding activity allows microRNAs to silence the expression of select genes in a targeted manner. Abnormal versions of microRNAs have been implicated in the growth of several types of cancer.

The paper from Carnegie's Karina Conkrite, Maggie Sundby and David MacPherson--as well as authors from other institutionsfocuses on a cluster of microRNAs called miR-17~92. Recent research has shown that aberrant versions of this cluster are involved in preventing pre-cancerous cells from dying and allowing them to proliferate into tumors. Previous work has shown that miR-17~92 can be involved in the survival of lymphoma and leukemia cells by reducing the levels of a tumor-suppressing protein called PTEN.

The team's new research shows that miR-17~92 can also be involved in retinoblastoma, although it does not act in the same way, via the PTEN protein, as it does in other types of cancers. Rather, miR-17~92 acts to help cells that lack the tumor-suppressing Rb protein to proliferate.

First the team demonstrated that miR-17~92 is expressed in higher-than-usual quantiti
'/>"/>

Contact: David MacPherson
macpherson@ciwemb.edu
410-246-3084
Carnegie Institution
Source:Eurekalert

Page: 1 2

Related biology news :

1. Dissecting the genomes of crop plants to improve breeding potential
2. Researchers find potential key for unlocking biomass energy
3. Neural stem progenitor cell transplantation’s potential to aid spinal cord injury tested
4. Scientists devise way to sort brain cells for potential transplants
5. BUSM study identifies new potential approaches to treat myelofibrosis
6. Potential impact of cinnamon on multiple sclerosis studied
7. UF review of resveratrol studies confirms potential health boost
8. U-M researchers find potential new way to fight sepsis
9. Researchers discover potential cause of chronic painful skin
10. Adjuvant combo shows potential for universal influenza vaccine
11. Potential treatment for deadly E. coli disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... on September 13, 2014. The fire is human-caused and ... 2,300 acres in size and is mostly being fueled ... calm Monday night due to higher humidity. Yesterday ... beginning to construct a fireline on the West and North ... on the fire: , 7 20-person Crews, 4 Hot Shot ...
(Date:9/16/2014)... viruses that make us sick can take up residence ... sneeze, cough or other troublesome symptom, according to new ... Louis. , On average, healthy individuals carry about ... report online in BioMed Central Biology . The ... diversity of viruses in healthy people. , The ...
(Date:9/16/2014)... doom for the dinosaurs 66 million years ago decimated ... greater extent than their deciduous peers, according to a ... in the journal PLOS Biology . , ... of fossilized leaves of angiosperms flowering plants ... the ecology of a diverse plant community thriving during ...
Breaking Biology News(10 mins):Healthy humans make nice homes for viruses 2Healthy humans make nice homes for viruses 3Meteorite that doomed dinosaurs remade forests 2Meteorite that doomed dinosaurs remade forests 3Meteorite that doomed dinosaurs remade forests 4
... researchers, Eric Hoffman, PhD, of Childrens Research Institute ... relatively short order, medicines next innovation--individualized molecular therapies--will ... dystrophies, and other disorders. In the ... Medicine, Dr. Hoffman posits that the results of ...
... living in the United States are suffering from some ... in Africa, Asia, and Latin America, says the Editor-in-Chief ... entitled Poverty and Neglected Diseases in the Other America, ... Vaccine Institute) says that there is evidence that the ...
... examined, Hispanic women were found to have the highest prevalence ... Asian Americans having the lowest prevalence (0.5 percent), according to ... Mutations in the tumor suppressor gene BRCA1 confer high ... age 70 years has been estimated at 65 percent for ...
Cached Biology News:New clinical trial results show how personalized medicine will alter treatment of genetic disorders 2Poor Americans in the United States suffer hidden burden of parasitic and other neglected diseases 2Varying prevalence among ethnic groups of gene mutation that increases risk of breast cancer 2Varying prevalence among ethnic groups of gene mutation that increases risk of breast cancer 3
(Date:9/17/2014)... Escape Alert, LLC . filed international patents for an ... if their pet has escaped and enable them to track their ... pet’s body. This is the first implantable microchip with GPS. ... for many years, they are passive until read by scanners, do ... location or alert the owner that the pet has escaped. ...
(Date:9/17/2014)... NASA’s MESSENGER has just celebrated its 10 year ... have one of its latch valves, V27200-818, operating onboard ... investigation of the planet Mercury. It is only the ... provided a vast amount of information and images of ... utilize solenoids that also include permanent magnets to maintain ...
(Date:9/17/2014)... The Alliance for Clinical Research ... collaborative building a global system to enhance safety, ... Phase 3 of its Site Accreditation and Standards ... Kalali, Vice-President, Global Head, Neuroscience Center of Excellence ... Quality Integration (CQI) Consulting will lead the effort ...
(Date:9/16/2014)... 2014 This report analyzes the worldwide markets for ... Hardware, and Biocontent. The report provides separate comprehensive analytics for ... , Europe , Asia-Pacific ... of World. Annual estimates and forecasts are provided for the ... provided for these markets. Market data and analytics are derived ...
Breaking Biology Technology:Implantable Microchip for Pets with GPS Tracking - Patent Filed by Escape Alert, LLC. 2Implantable Microchip for Pets with GPS Tracking - Patent Filed by Escape Alert, LLC. 3Global Standards Initiative for Clinical Research Sites Advances 2Global Standards Initiative for Clinical Research Sites Advances 3Global Standards Initiative for Clinical Research Sites Advances 4Global Bioinformatics Industry 2Global Bioinformatics Industry 3Global Bioinformatics Industry 4Global Bioinformatics Industry 5Global Bioinformatics Industry 6Global Bioinformatics Industry 7Global Bioinformatics Industry 8Global Bioinformatics Industry 9Global Bioinformatics Industry 10Global Bioinformatics Industry 11Global Bioinformatics Industry 12Global Bioinformatics Industry 13Global Bioinformatics Industry 14Global Bioinformatics Industry 15Global Bioinformatics Industry 16Global Bioinformatics Industry 17Global Bioinformatics Industry 18Global Bioinformatics Industry 19Global Bioinformatics Industry 20Global Bioinformatics Industry 21Global Bioinformatics Industry 22Global Bioinformatics Industry 23
... ... costs by partnering with a highly specialized medical tubing manufacturer , ... (PRWEB) March 10, 2010 -- There’s a ... medical tubing supplier. Unless certain steps are taken to ensure that designs and ...
... husband and wife research team has found a way to ... injuries faster and more simply than current methods. And they,ve ... car wreck, bomb blast or disease leaves too little cover. ... and mechanical & aerospace engineering at Case Western Reserve University, ...
... ... ... ... ...
Cached Biology Technology:Medical Device Designers Avoid the Pitfalls of Outsourcing Medical Tubing 2Medical Device Designers Avoid the Pitfalls of Outsourcing Medical Tubing 3Cleveland researchers use natural and artificial sheaths to mend traumatic bone loss 2Cleveland researchers use natural and artificial sheaths to mend traumatic bone loss 3Abbott Enhances Pharmaceutical Pipeline with Acquisition of Facet Biotech 2Abbott Enhances Pharmaceutical Pipeline with Acquisition of Facet Biotech 3Abbott Enhances Pharmaceutical Pipeline with Acquisition of Facet Biotech 4Abbott Enhances Pharmaceutical Pipeline with Acquisition of Facet Biotech 5Abbott Enhances Pharmaceutical Pipeline with Acquisition of Facet Biotech 6Abbott Enhances Pharmaceutical Pipeline with Acquisition of Facet Biotech 7Abbott Enhances Pharmaceutical Pipeline with Acquisition of Facet Biotech 8Abbott Enhances Pharmaceutical Pipeline with Acquisition of Facet Biotech 9Abbott Enhances Pharmaceutical Pipeline with Acquisition of Facet Biotech 10
... The Label IT siRNA Tracker Intracellular ... to directly label and deliver siRNA, of ... manner, for in vitro tracking experiments. Subcellular ... expression can be monitored following introduction of ...
... This CLS number is a ... easily match Cornings product number. ... please order under the old ... customer service for assistance. ID ...
... through the extracellular matrix (ECM) is an ... cells initiate invasion by adhering to and ... Proteolytic enzymes, such as MMP collagenases, dissolve ... membrane) surrounding the blood vessels to allow ...
... Cell Invasion Assay is designed to determine ... as a significant barrier to invasion or ... in a convenient, high-throughput, 96-well format. The ... all types of adherent cells such as ...
Biology Products: