Navigation Links
Potential new approach to regenerating skeletal muscle tissue
Date:6/1/2012

An innovative strategy for regenerating skeletal muscle tissue using cells derived from the amniotic fluid is outlined in new research published by scientists at the UCL Institute of Child Health.

The paper shows that damaged muscle tissues can be treated with cells derived from the fluids which surround the fetus during development, leading to satisfactory regeneration and muscle activity. The treatment resulted in longer survival in mice affected by a muscle variant of spinal muscular atrophy. This is the first time that regeneration of diseased muscle tissue has been obtained using cells derived from amniotic fluid.

The research appears in the journal Stem Cells, is authored by Dr Paolo de Coppi (UCL Institute of Child Health and surgeon at Great Ormond Street Hospital) and colleagues in Paris and Padova, and represents an impressive development in the growing field of regenerative medicine.

Muscle derived stem cells are presently considered the best source for muscle regeneration. However they cannot be used to treat muscular dystrophies because the stem cells themselves are affected in individuals with these conditions. Due to this challenge, other cell sources have been explored but so far no definitive treatment has been successful.

De Coppi's team has demonstrated that intravenous transplantation of amniotic fluid stem (AFS) cells enhances the muscle strength and improves the survival rate of the affected animals. This is the first study to demonstrate the functional and stable integration of AFS cells into skeletal muscle, highlighting their value as a cell source for the treatment of muscular dystrophies.

However, the research is still at a relatively early stage as the work has only been carried out in animal models.

Dr Coppi said: "Spinal muscular atrophy is a genetic disease affecting one in 6,000 births. It is currently incurable and in its most severe form children with the condition may not survive long into childhood. Children with a less severe form face the prospect of progressive muscle wasting, loss of mobility and motor function. There is an urgent need for improved treatments.

"We are excited by this potential new approach for regenerating skeletal muscle tissue, but much more research is needed. We now need to perform more in-depth studies with human AFS cells in mouse models to see if it is viable to use cells derived from the amniotic fluid to treat diseases affecting skeletal muscle tissue."


'/>"/>

Contact: David Weston
d.weston@ucl.ac.uk
44-203-108-3844
University College London
Source:Eurekalert

Related biology news :

1. Nuisance seaweed found to produce compounds with biomedical potential
2. Folic acid food enrichment potentially protective against childhood cancers
3. Gene therapy for hearing loss: Potential and limitations
4. Beehive extract shows potential as prostate cancer treatment
5. Researchers find potential dark side to diets high in beta-carotene
6. Gallbladder shown as potential stem cell source for regenerative liver and metabolic disease
7. Researchers report potential for a moderate New England red tide in 2012
8. Interventional radiology: Potential breakthrough to treat mens enlarged prostate
9. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
10. Epigenetic signatures direct the repair potential of reprogrammed cells
11. Researchers find safer way to use common but potentially dangerous medication
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... AVIV, Israel , December 7, 2016 ... with the expansion of its patent portfolio, which grew to over 40 ... , , ... by its recently filed patent entitled " System, Device, and ... covers technology that enables device makers to forego costly hardware components needed ...
(Date:12/6/2016)... Dec. 6, 2016 Valencell , the leading ... has seen a third consecutive year of triple digit ... in 2016 with a 360 percent increase in companies ... increase was driven by sales of its wrist and ... in its technology for hearables for fitness and healthcare ...
(Date:12/2/2016)... AUSTIN, Texas , Dec. 1, 2016 /PRNewswire/ ... provider, today announced BioLock , an electrocardiogram ... and health monitoring, a key IoT asset. The ... embedded into a vehicle,s steering wheel and mobile ... a simple touch. As vehicle technology ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... report analyzes the worldwide markets for Biostimulants in US$ by ... Extract Based, and Others. The report also analyzes the Global ... Crops, and Others. The report provides separate comprehensive analytics for ... , Europe , Asia-Pacific ... of World. Annual estimates and forecasts are provided for the ...
(Date:12/8/2016)... Dec. 8, 2016  Biotheranostics today announced that ... of the Breast Cancer Index (BCI) in identifying ... are most at-risk for disease recurrence and might ... from three studies advancing the understanding of the ... tumor biology and inform decisions related to patient ...
(Date:12/8/2016)... 2016 Oxford Gene ... seine Palette an anpassbaren SureSeq™ NGS-Panels mit dem ... das ein schnelles und kostengünstiges Studium der Varianten ... eine Erkennung von Einzel-Nukleotid-Variationen (Single Nucleotide Variation, SNV) ... kleinen Panel und ermöglicht eine individuelle Anpassung durch ...
(Date:12/8/2016)... Francisco, CA (PRWEB) , ... December 08, 2016 ... ... Oculus as finalists in the World Technology Awards. uBiome is one of just ... received across all categories. , In addition to uBiome, companies nominated as finalists ...
Breaking Biology Technology: