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Potential new HIV drug may help patients not responding to treatment
Date:3/31/2009

lthough they do not exclude this possibility. They are now keen to carry out further research to explore how D-1mT is working.

"The effect D-1mT seemed to have on viral load was really encouraging but it was a surprise to us - we didn't expect D-1mT to work only in macaques that were already being treated with ART. It seems that D-1mT synergises with ART and we would really like to find out how this works," said Dr Boasso.

In healthy people, the IDO enzyme controls allergic reactions and autoimmune diseases and it also stops the foetus from being rejected in pregnancy. As D-1mT blocks IDO, the researchers say that its effects may need to be tested in SIV-infected macaques over a longer time, to determine if taking the drug could increase the risk of these conditions.

D-1mT is currently in Phase I clinical trials to test its safety and potential efficacy as a treatment for cancer, which should indicate whether the drug is suitable for treating human patients. The researchers hope that if D-1mT proves safe in the initial trials for cancer and shows further promise for treating HIV, trials for using D-1mT as a treatment for HIV could begin as early as 5 years from now.


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Contact: Lucy Goodchild
lucy.goodchild@imperial.ac.uk
44-020-759-46702
Imperial College London
Source:Eurekalert

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