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Potential lung cancer vaccine shows renewed promise
Date:3/20/2014

increased interferon gamma levels and boosted the T-cell response to MUC1-expressing cancer cells. When administered by themselves, both tecemotide and cisplatin reduced the number of lung tumors. However, combining these therapies enhanced their impact, suggesting that tecemotide may increase cisplatin's anticancer activity.

Though radiation therapy did reduce the number of lymphocytes, it did not appear to hamper the immune response. In addition, interferon levels actually increased several hours after radiation treatments.

"Radiation may actually be helpful by exposing targets for the vaccine," said DeGregorio.

While this study revives hope for tecemotide as a potential NSCLC therapy, there are still questions to be answered. Researchers need to further refine these therapies to determine which protocols provide the best survival benefits. In addition, tecemotide can only be effective if it does not exhaust the immune system in the process. Still, the research provides a ray of hope for patients with few options.

"We believe this vaccine could be coupled with standard treatments to create a maintenance therapy," said DeGregorio. "If we can help patients with a life expectancy of 18 to 20 months increase that to 30 months or more, with a high quality of life, that's a big benefit."


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Contact: Dorsey Griffith
dorsey.griffith@ucdmc.ucdavis.edu
916-734-9118
University of California - Davis Health System
Source:Eurekalert

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