Navigation Links
Potential drug molecule shows enhanced anti-HIV activity
Date:8/9/2012

Researchers from Munich and Naples have shown that minimal modification of a synthetic peptide with anti-HIV activity results in a new compound with more than two orders of magnitude higher binding affinity to the chemokine receptor CXCR4 and greatly improved anti-HIV activity. This could be a step toward the design of new, more effective drugs against AIDS, inflammatory diseases, and some forms of cancer.

Different strains of HIV-1 use either the chemokine receptor CCR5 or CXCR4 for entry into immune cells. While drugs that block usage of CCR5 by the virus are already available for anti-HIV therapy, no drugs have been approved that prevent the virus from using the CXCR4 receptor. Because the new cyclic peptide may be used to block CXCR4, it is a promising new drug candidate to block HIV-1 infections.

An international, interdisciplinary team including researchers in pharmaceutical radiochemistry and chemistry at the Technische Universitt Mnchen (TUM), a group of molecular modelers at the University of Naples, and virologists at the Helmholtz Zentrum Mnchen reported the results in Angewandte Chemie International Edition. This work was initiated by the radiochemists and organic chemists at TUM, who realized that their approach to modifying peptides as high-affinity CXCR4 ligands for imaging of cancers also has the potential to open a whole new area of drug research.

The researchers used a smart trick to augment both the binding affinity and the anti-HIV activity of an already known lead structure: They shifted one of the important side chains from the carbon to a neighboring nitrogen, thus fixing the skeleton of the molecule to present its binding groups in an improved orientation.

The cyclic structure of the peptide, with one unnatural D-amino acid (the mirror image of the natural amino acid tyrosine) and one so-called "peptoid" structure, makes the compound stable against enzymatic degradation and thus suitable fo
'/>"/>

Contact: Patrick Regan
regan@zv.tum.de
49-089-289-10515
Technische Universitaet Muenchen
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Epigenetic signatures direct the repair potential of reprogrammed cells
2. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
3. Interventional radiology: Potential breakthrough to treat mens enlarged prostate
4. Researchers report potential for a moderate New England red tide in 2012
5. Gallbladder shown as potential stem cell source for regenerative liver and metabolic disease
6. Researchers find potential dark side to diets high in beta-carotene
7. Beehive extract shows potential as prostate cancer treatment
8. Gene therapy for hearing loss: Potential and limitations
9. Folic acid food enrichment potentially protective against childhood cancers
10. Nuisance seaweed found to produce compounds with biomedical potential
11. Potential new approach to regenerating skeletal muscle tissue
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Potential drug molecule shows enhanced anti-HIV activity
(Date:8/20/2014)... and salty aroma of sunscreen and seawater signals a ... reporting that the idyllic beach vacation comes with an ... and into the sea, they can become toxic to ... main course for many other marine animals. Their study ... Technology . , Antonio Tovar-Sanchez and David Snchez-Quiles point ...
(Date:8/20/2014)... could one day be made out of cocoa, rice ... reporting. The novel process they developed and their results, ... and plastic waste problems, appear in the ACS journal ... and colleagues at the Italian Institute of Technology point ... its production reached 288 million tons worldwide, but its ...
(Date:8/20/2014)... grows to about 4,000 members, it triggers an important ... a special type of comb used for rearing male ... Department of Neurobiology and Behaviour at Cornell University, led ... of honeybee colonies. The results are published in Springer,s ... , Reproduction isn,t always a honeybee colony,s top ...
Breaking Biology News(10 mins):Worker bees 'know' when to invest in their reproductive future 2
... , MADISON - The continued growth of cropland ... agricultural landscapes in the Midwest. A Great Lakes ... simplification is associated with increased crop pest abundance ... by perennial bioenergy crops. While the relationship ...
... LEXINGTON, Ky. − A team of researchers led by ... is making a connection from prehistoric times to the ... create a replacement for oil and coal shale deposits. ... the earth,s energy supply. Tom Niehaus, completing his ...
... Health care laws to protect patients, privacy make ... and test the safety and usability of medical products ... a result, usability errors and hazards may be overlooked, ... issue of Ergonomics in Design, human factors/ergonomics ...
Cached Biology News:Landscape change leads to increased insecticide use in the Midwest 2University of Kentucky-led research could be path to new energy sources 2
(Date:8/20/2014)... JOSE, Calif. , Aug. 20, 2014 /PRNewswire-iReach/ ... highlights the transformative collaboration between the school,s bioengineering ... As part of the Intel® Software Academic Program, ... computer sciences and the human body.  ... The study exhibits the work of Dr. ...
(Date:8/19/2014)... (PRWEB) August 19, 2014 Shimadzu ... chromatography systems, Prominence-i and Nexera-i, adding to the ... Combining excellent functionality, an intuitive operating environment, and ... a more efficient workflow for conventional to ultra-high-speed ... innovative, intuitive and intelligent design so users can ...
(Date:8/19/2014)... CA (PRWEB) August 19, 2014 Robin ... Parkinson’s disease can take on an individual. Symptoms ... decreased facial expression, problems swallowing and severe depression. ... the dying off of dopamine producing neurons of the ... from a disease that slowly and progressively gets worse, ...
(Date:8/19/2014)... , Aug. 19, 2014   Synthetic Biologics, ... developing novel anti-infective biologic and drug programs targeting ... announced today that its novel C. difficile ... 54 th Interscience Conference on Antimicrobial Agents ... Washington D.C. Synthetic Biologics, ...
Breaking Biology Technology:Intel and University of San Diego Bioengineering Department Release Case Study on Health Sciences Research 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 3As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 2As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 3Synthetic Biologics Announces Late-Breaking Poster Presentation for C. difficile Program at 54th ICAAC 2Synthetic Biologics Announces Late-Breaking Poster Presentation for C. difficile Program at 54th ICAAC 3Synthetic Biologics Announces Late-Breaking Poster Presentation for C. difficile Program at 54th ICAAC 4
... Amylin Pharmaceuticals, Inc. (Nasdaq: AMLN ) will be ... on Tuesday, June 9, 2009 at 10:45 a.m. ET / ... and chief executive officer of Amylin Pharmaceuticals, will provide a corporate ... be webcast, and a recording will be made available following the ...
... Ala., June 3 EGEN, Inc. (EGEN), a biopharmaceutical company ... Khursheed Anwer, Ph.D., has been promoted to President and Chief ... who has retired from the position of President and Chief ... on scientific and business affairs and retain his position on ...
... ... free availability of online free tutorial suites on the UCSC Genome Browser. , ... (PRWEB) June 3, 2009 -- University of ... UCSC Genome Browser , a powerful and popular freely available web-based tool for mining ...
Cached Biology Technology:EGEN, Inc. Announces the Promotion of Khursheed Anwer, Ph.D., to President and Chief Scientific Officer 2New and Expanded Free Tutorials on UCSC Genome Browser Now Available 2New and Expanded Free Tutorials on UCSC Genome Browser Now Available 3
... time to just 15 minutes! The name ... can be drawn between this exciting new laboratory ... foods. Instant meals consumed by astronauts, explorers ... are reconstituted by adding water. The Instant ...
Request Info...
Candida (IgG) -Ab EIA Sample Size: 5 l...
... MOISTURE. AVOID FREEZE/THAW CYCLES. This kit allows ... vitro by DNA affinity-mediated capture of ... In this assay, mono- and oligonucleosomes are ... 3 (H3) biotin-labeled antibody then binds to ...
Biology Products: