Navigation Links
Potential anti-cancer treatment method wins Kaye Award
Date:12/19/2011

Jerusalem -- A strategy for inhibiting a protein that is associated with the spread of cancer has won for a Hebrew University of Jerusalem Ph.D. student in chemistry one of this year's Kaye Innovation Awards at the university.

The innovation developed by Yftah Tal-Gan, a student of Prof. Chaim Gilon and Prof. Alexander Levitzki at the Institute of Chemistry, focuses on the inhibition of Protein Kinase B (PKB, also called Akt). Since the activation of PKB is associated with cancer, selective inhibition of this protein becomes a promising strategy for targeted cancer therapy.

Tal-Gan's method is based on mimicking the interaction of PKB with other proteins with which it comes into contact. This he accomplished through the use of peptides. Since peptides are built from the same amino acid building blocks as proteins, the peptides can thus be used as protein "mimics." Peptides, however, lack important pharmacological properties, such as stability.

Through chemical engineering, Tal-Gan managed to convert an active peptide inhibitor of PKB, named PTR6154, into a stable peptide "mimic" (peptidomimetic) that combines biological activity with favorable pharmacological properties.

The peptide could be used as a potential anti-cancer treatment that would operate through inhibiting PKB from performing its role of inducing cancer cell survival and cell division. The outcome is that the cancer cells would become susceptible to death signals and therefore die (unlike untreated cancer cells that are not susceptible to death signals and therefore do not die). The peptidomimetic could also potentially be combined with specific anti-cancer drugs, thus further enhancing the efficacy of the treatment method.


'/>"/>
Contact: Jerry Barach
jerryb@savion.huji.ac.il
972-258-82904
The Hebrew University of Jerusalem
Source:Eurekalert  

Page: 1

Related biology news :

1. UI researchers find potentially toxic substance present in Chicago air
2. Scientists from Granada find a potential treatment to prevent diabetes and obesity
3. FSU researchers discovery leads to $1.5 million grant, potential new treatment of liver fibrosis
4. Simple chemical procedure augments therapeutic potential of stem cells
5. Chemist to donate potential pharmaceutical royalties to Madagascar
6. Duke study pinpoints potential green collar job growth in US
7. Researchers recreate SARS virus, open door for potential defenses against future strains
8. First trial in patients with a potential treatment of the incurable ALS muscle disease
9. Epilepsy drug shows potential for Alzheimers treatment
10. In just 5 years, gene discovery to clinical trial of potential treatment
11. UC Davis team refines cancer treatments to reduce potential nerve damage
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Potential anti-cancer treatment method wins Kaye  Award
(Date:6/2/2016)...   The Weather Company , an IBM Business (NYSE: ... capability in which consumers will be able to interact with ... via voice or text and receive relevant information about the ... Marketers have long sought an advertising solution that can create ... relevant and valuable; and can scale across millions of interactions ...
(Date:5/16/2016)... May 16, 2016   EyeLock LLC , a ... the opening of an IoT Center of Excellence in ... expand the development of embedded iris biometric applications. ... of convenience and security with unmatched biometric accuracy, making ... aside from DNA. EyeLock,s platform uses video technology to ...
(Date:4/28/2016)... First quarter 2016:   , ... the first quarter of 2015 The gross margin was ... 18.8) and the operating margin was 40% (-13) Earnings ... flow from operations was SEK 249.9 M (21.2) , ... SEK 7,000-8,500 M. The operating margin for 2016 is ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... June 27, 2016  Global demand for enzymes ... through 2020 to $7.2 billion.  This market includes ... cleaning products, biofuel production, animal feed, and other ... and biocatalysts). Food and beverages will remain the ... increasing consumption of products containing enzymes in developing ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... medical technologies, services and solutions to the healthcare market. The company's primary focus ... distribution, manufacturing, sales and marketing strategies that are necessary to help companies efficiently ...
(Date:6/24/2016)... DIEGO , June 24, 2016 ... more sensitively detects cancers susceptible to PARP inhibitors ... circulating tumor cells (CTCs). The new test has ... HRD-targeted therapeutics in multiple cancer types. ... targeting DNA damage response pathways, including PARP, ATM, ...
(Date:6/23/2016)... 23, 2016   Boston Biomedical , an ... designed to target cancer stemness pathways, announced that ... Orphan Drug Designation from the U.S. Food and ... cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin is ... inhibit cancer stemness pathways by targeting STAT3, and ...
Breaking Biology Technology: