Navigation Links
Potential anti-cancer treatment method wins Kaye Award
Date:12/19/2011

Jerusalem -- A strategy for inhibiting a protein that is associated with the spread of cancer has won for a Hebrew University of Jerusalem Ph.D. student in chemistry one of this year's Kaye Innovation Awards at the university.

The innovation developed by Yftah Tal-Gan, a student of Prof. Chaim Gilon and Prof. Alexander Levitzki at the Institute of Chemistry, focuses on the inhibition of Protein Kinase B (PKB, also called Akt). Since the activation of PKB is associated with cancer, selective inhibition of this protein becomes a promising strategy for targeted cancer therapy.

Tal-Gan's method is based on mimicking the interaction of PKB with other proteins with which it comes into contact. This he accomplished through the use of peptides. Since peptides are built from the same amino acid building blocks as proteins, the peptides can thus be used as protein "mimics." Peptides, however, lack important pharmacological properties, such as stability.

Through chemical engineering, Tal-Gan managed to convert an active peptide inhibitor of PKB, named PTR6154, into a stable peptide "mimic" (peptidomimetic) that combines biological activity with favorable pharmacological properties.

The peptide could be used as a potential anti-cancer treatment that would operate through inhibiting PKB from performing its role of inducing cancer cell survival and cell division. The outcome is that the cancer cells would become susceptible to death signals and therefore die (unlike untreated cancer cells that are not susceptible to death signals and therefore do not die). The peptidomimetic could also potentially be combined with specific anti-cancer drugs, thus further enhancing the efficacy of the treatment method.


'/>"/>
Contact: Jerry Barach
jerryb@savion.huji.ac.il
972-258-82904
The Hebrew University of Jerusalem
Source:Eurekalert  

Page: 1

Related biology news :

1. UI researchers find potentially toxic substance present in Chicago air
2. Scientists from Granada find a potential treatment to prevent diabetes and obesity
3. FSU researchers discovery leads to $1.5 million grant, potential new treatment of liver fibrosis
4. Simple chemical procedure augments therapeutic potential of stem cells
5. Chemist to donate potential pharmaceutical royalties to Madagascar
6. Duke study pinpoints potential green collar job growth in US
7. Researchers recreate SARS virus, open door for potential defenses against future strains
8. First trial in patients with a potential treatment of the incurable ALS muscle disease
9. Epilepsy drug shows potential for Alzheimers treatment
10. In just 5 years, gene discovery to clinical trial of potential treatment
11. UC Davis team refines cancer treatments to reduce potential nerve damage
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Potential anti-cancer treatment method wins Kaye  Award
(Date:4/26/2016)... , April 27, 2016 ... the  "Global Multi-modal Biometrics Market 2016-2020"  report to ... ) , The analysts forecast the ... CAGR of 15.49% during the period 2016-2020.  ... number of sectors such as the healthcare, BFSI, ...
(Date:4/15/2016)... 15, 2016  A new partnership announced today ... underwriting decisions in a fraction of the time ... and high-value life insurance policies to consumers without ... With Force Diagnostics, rapid testing (A1C, Cotinine and ... (blood pressure, weight, pulse, BMI, and activity data) ...
(Date:4/14/2016)... , April 14, 2016 ... and Malware Detection, today announced the appointment of ... the new role. Goldwerger,s leadership appointment comes ... the heels of the deployment of its platform at ... behavioral biometric technology, which discerns unique cognitive and physiological ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... Brooklyn, NY (PRWEB) , ... June 24, 2016 , ... ... 15mm, machines such as the Cary 5000 and the 6000i models are higher end ... height is the height of the spectrophotometer’s light beam from the bottom of the ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... pleased to announce the launch of their brand, UP4™ Probiotics, into Target stores ... 35 years, is proud to add Target to its list of well-respected retailers. ...
(Date:6/23/2016)... A person commits a crime, and the detective ... the criminal down. An outbreak of foodborne illness ... (FDA) uses DNA evidence to track down the bacteria that ... It,s not. The FDA has increasingly used a complex, cutting-edge ... illnesses. Put as simply as possible, whole genome sequencing is ...
(Date:6/23/2016)... MONICA, Calif. , June 23, 2016  The Prostate Cancer Foundation ... pioneer increasingly precise treatments and faster cures for prostate cancer. Members of the ... institutions across 15 countries. Read More About the Class ... ... ...
Breaking Biology Technology: