Navigation Links
Potent spider toxin 'electrocutes' German, not American, cockroaches
Date:7/11/2014

e of sodium causes an electrical signal to be sent down the nerve, eventually reaching the spinal cord and brain so the body can react.

"Sodium channels are the fastest ion channels in the human body and are needed to experience nearly every sensation, so mutations in them can lead to severe disorders of the nerves, muscles and heart," Bosmans says. That makes them a critical target for scientific study.

To understand the channels better, Bosmans and his team insert the protein's gene into frog eggs, which are large and easy to study. They can then use electrodes to monitor the flow of sodium into the cells. Adding spider toxins that interfere with the function of the channels sheds light on the channels' activity, since different toxins inhibit different parts of the protein, causing different effects. In addition to testing human sodium channels, the team sometimes works with sodium channels from insects.

Because his laboratory recently acquired the gene for the German cockroach sodium channel, Bosmans' team tested Dc1a on the protein and saw a startling increase in the channels' activity. "Sodium poured into the cells. In a bug, that would cause massive seizures, much like being electrocuted," says Bosmans. "Luckily, the toxin doesn't act on human sodium channels."

Curious about the difference between the two cockroach species' channels, they first identified the region of the channel that the toxin targets, but it turned out to be exactly the same in the two bugs. Digging deeper, they found a region nearby that differed by just two amino acids, the basic building blocks of the proteins. When mutations were made in the German version so that its amino acids were the same as the American version's, the German cockroach sodium channel reacted like the American one.

The team's next step is to test the toxin on other insect species to determine its full range. Now that they know how important this region of sodium chann
'/>"/>

Contact: Catherine Kolf
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Epigenetic signatures direct the repair potential of reprogrammed cells
2. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
3. Interventional radiology: Potential breakthrough to treat mens enlarged prostate
4. Researchers report potential for a moderate New England red tide in 2012
5. Gallbladder shown as potential stem cell source for regenerative liver and metabolic disease
6. Researchers find potential dark side to diets high in beta-carotene
7. Beehive extract shows potential as prostate cancer treatment
8. Gene therapy for hearing loss: Potential and limitations
9. Folic acid food enrichment potentially protective against childhood cancers
10. Nuisance seaweed found to produce compounds with biomedical potential
11. Potential new approach to regenerating skeletal muscle tissue
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Potent spider toxin 'electrocutes' German, not American, cockroaches
(Date:7/21/2015)... , July 21, 2015 Passwords ... as seen in the recent U.S. Office of ... solution to the infosec conundrum, but developers and ... stored. To address this dilemma, Biometrics-as-a-Service provider HYPR ... Biometric Tokenization SDK for third party integration. ...
(Date:7/13/2015)... Conn. , Jul. 13, 2015 NXT-ID, ... "Company"), a biometric authentication company focused on the ... has filed provisional patent 62/188684 for ... achieves another new convenient and secure method to ... new, innovative payment methods, introduced with its groundbreaking ...
(Date:7/9/2015)... , July 9, 2015  Unchained Labs ... announcing its acquisition of Avid Nano. Avid Nano ... scattering (DLS) systems.    Also today, ... fastest and easiest to use protein sizing system. ... measures a protein,s hydrodynamic size, size distribution, aggregation ...
Breaking Biology News(10 mins):HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4Unchained Labs just can't get enough, acquires Avid Nano, rocks out the new pUNk! 2
... and the stages of development for the last major set ... natural killer (NK) cells, one of the body's front-line defenses ... four discrete stages. They also found that this happens in ... , Key discoveries made decades ago in animals and humans ...
... University, Sweden has shown in a new study, published in ... on a male collared flycatcher's forehead reflects how well the ... white spot is also attractive to female birds searching for ... explain why individuals of a species differ in appearance and ...
... common ear infections will be the focus of ground-breaking ... , The research will aim to understand why some ... heal at all) by identifying which genes are responsible ... drum. , According to the World Health Organisation, almost ...
Cached Biology News:Front-line immune cells mature in four stages, study shows 2Attractive birds more immune against bird flu 2World first research to speed up cure for ear infections 2
(Date:7/30/2015)... Dallas, Texas (PRWEB) , ... July 30, 2015 , ... ... professional and in-depth study on the current state of the global Propanol market with ... are Sinopec, CNPC, BASF, Eastman, Dow, Carboclor, Mitsui Chemicals, Oxea, ISU Chemical, Sanofi, Royal ...
(Date:7/30/2015)... 60,000 customers across the globe, ISN improves the efficiency and effectiveness of contractor management ... safe and reliable contractors in over 80 countries. ... ... Over 60,000 Worldwide Customers In More Than 80 ... Headquartered in Dallas, TX , ISN has additional offices in ...
(Date:7/30/2015)... ... July 30, 2015 , ... ... fluid applications and designed for continuous operation up to 1500 bar. The sanitary ... safety, efficiency, and preventing toxic contamination. , The Pony™ NS2006L homogenizer is an ...
(Date:7/29/2015)... / Japan (Q2 2015: +14% CER / 20% ... high-single-digit growth in China , as well as solid contributions ... Europe / Middle East / ... showed gains in Germany , Turkey ... CER / 49% of sales) grew 11%, excluding U.S. HPV sales, on demand ...
Breaking Biology Technology:Global Propanol Market Technical Data and Manufacturing Analysis 2020 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 3ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3GEA Announces the Pony™ NS2006L… a Self-contained, High Pressure Lab Homogenizer for Product Development Ensuring Maximum Efficiency and Safety 2QIAGEN Reports Results for Second Quarter and First Half of 2015 2QIAGEN Reports Results for Second Quarter and First Half of 2015 3QIAGEN Reports Results for Second Quarter and First Half of 2015 4QIAGEN Reports Results for Second Quarter and First Half of 2015 5QIAGEN Reports Results for Second Quarter and First Half of 2015 6QIAGEN Reports Results for Second Quarter and First Half of 2015 7QIAGEN Reports Results for Second Quarter and First Half of 2015 8QIAGEN Reports Results for Second Quarter and First Half of 2015 9QIAGEN Reports Results for Second Quarter and First Half of 2015 10
... April 30 /PRNewswire/ - ImmunoVaccine Technologies Inc. (IVT),a ... a,novel depot vaccine delivery system used to increase ... additional patents to protect the,DepoVax(TM) concept., "The ... highly effective with a single dose," remarked Marc ...
... Single Molecule Fluorescence and ... Nanoscale Measurement Techniques -, ... nanoscale whole genome imaging platforms for genetic,diagnostics, personalized medicine ... Paul R. Selvin, Ph.D., to its,Scientific Advisory Board (SAB). ...
... Systems Fuel Faster Time to Discovery for ... Causes and Cures of Disease, BOSTON, April 30 ... seek to accelerate sequencing,genomes of varied arrays of organisms from ... and cures of diseases that plague mankind,breakthrough technology from SGI ...
Cached Biology Technology:ImmunoVaccine Technologies Patents DepoVax(TM) Vaccine Platform 2BioNanomatrix Announces Appointment of Paul R. Selvin to Its Scientific Advisory Board 2BioNanomatrix Announces Appointment of Paul R. Selvin to Its Scientific Advisory Board 3SGI Breakthrough Technology Empowers Genome Center Research Around the World 2SGI Breakthrough Technology Empowers Genome Center Research Around the World 3SGI Breakthrough Technology Empowers Genome Center Research Around the World 4SGI Breakthrough Technology Empowers Genome Center Research Around the World 5
...
SDS-OutT Precipitation Reagent...
... Removal , , Removes ... cross-reactivity with other proteins , Simple, just ... Economical new surface technology, not based on ... with protein analysis. SurfactAway offers a simple ...
... provides high speed and excellent temperature uniformity. ... TGradient Thermocycler can be run without any ... silver block for 48 or 96 wells. ... or in-situ applications are available. The High ...
Biology Products: