Navigation Links
Potatoes may hold key to Alzheimer's treatment
Date:8/15/2008

A virus that commonly infects potatoes bears a striking resemblance to one of the key proteins implicated in Alzheimer's disease (AD), and researchers have used that to develop antibodies that may slow or prevent the onset of AD.

Studies in mice have demonstrated that vaccinations with the amyloid beta protein (believed to be a major AD contributor) to produce A antibodies can slow disease progression and improve cognitive function, possibly by promoting the destruction of amyloid plaques. Some early human trials have likewise been promising, but had to be halted due to the risk of autoimmune encephalitis.

One way to make Alzheimer's vaccinations safer would be to use a closely-related, but not human, protein as the vaccine, much like cowpox virus is used for smallpox immunizations.

In the August 15 Journal of Biological Chemistry, Robert Friedland and colleagues used this concept on an amyloid-like protein found in potato virus (PVY). They injected PVY into mice followed by monthly boosters for four months. The researchers found that the mice produced strong levels of antibodies that could attach to amyloid beta protein both in both solution and in tissue samples of Alzheimer's patients. And although the levels were lower, mice also developed A antibodies if given injections of PVY-infected potato leaf as opposed to purified PVY.

Friedland and colleagues note that potato virus is a fairly common infection that poses no risk to humans (many people have probably eaten PVY infected potatoes). While tests of PVY antibodies will ultimately determine how useful they can be, they may be a promising lead to treating this debilitating disease.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert  

Page: 1

Related biology news :

1. Drought tolerance in potatoes
2. Paradigm shift in Alzheimerss research: new treatments
3. Blood pressure response to daily stress provides clues for better hypertension treatment
4. Genes newly explained effect on height may change tumor disorder treatment
5. Songbirds may hold key to advances in treatment of brain degeneration
6. Treatment corrects severe insulin imbalance in animal studies
7. Video released of rapid Alzheimers improvement after new immune-based treatment
8. Fertility treatment in developing countries; a cycle of IVF for less than $200
9. New treatment approach promising for lymphoma patients in the developing world
10. Treatment delays result in poor outcomes for men with breast cancer
11. Counting tumor cells in blood predicts treatment benefit in prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Potatoes may hold key to Alzheimer's treatment
(Date:8/21/2014)... they are the ultimate source of all organic matter ... on algae, too, to suck up climate-warming carbon dioxide ... of the ocean. Now, by using a combination of ... that viruses infecting those algae are driving the life-and-death ... stays essentially the same, and this has important implications ...
(Date:8/21/2014)... that has implications for life in other extreme environments, ... system, LSU Associate Professor of Biological Sciences Brent Christner ... or NSF, this week published a paper confirming that ... 800 meters (2600 feet) beneath the surface of the ... that more than 400 subglacial lakes and numerous rivers ...
(Date:8/21/2014)... international standards process, will be available soon and will ... published in the OnlineFirst version of Nutrition in ... of the American Society for Parenteral and Enteral Nutrition ... of misconnection that can be harmful and even fatal ... join medical devices, components, and accessories to deliver fluids ...
Breaking Biology News(10 mins):Viruses take down massive algal blooms, with big implications for climate 2800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 2800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 3800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 4New feeding tube connectors will improve patient safety 2
... cities is often an overlooked resource. Years of manufacturing or ... scare residents away from using the land. As the local ... desire to grow food in cities with the fear that ... 10:35 am, Kristen McIvor of the Pierce Conservation District will ...
... STATION Dr. Xiuren Zhang, a biochemist and ... has been awarded almost $1.3 million from the National ... and plant stem cells, which ultimately could help breed ... science foundation,s CAREER program, which is given in "support ...
... Microbial fuel cells, chemical sensors for your iPhone, ... faster-charging batteries, safer nuclear power, and new crime scene ... on the science of materials, interfaces, and processing. Detailed ... AVS 60th International Symposium & Exhibition will take place ...
Cached Biology News:Fostering community gardens in an area with historic soil contamination 2AgriLife researcher Xiuren Zhang receives National Science Foundation CAREER grant 2AVS science symposium in Long Beach Oct. 27 -- Nov. 2 2
(Date:8/21/2014)... 2014 Pursuit Solutions ( http://www.pursuit-solutions.com ... and services for Life Sciences sales and marketing ... of New Commercial Sales Models” by Peter Robinson, ... The article examines some innovative models used to ... tested in the pharmaceutical market. Robinson grades the ...
(Date:8/21/2014)... Gallus BioPharmaceuticals , LLC, ... manufacturing organization (CMO) announced today that it has ... company focused on the development of innovative approaches ... anti-prostate specific membrane antigen (PSMA) monoclonal antibody used ... the agreement the antibody will be produced in ...
(Date:8/21/2014)... August 21, 2014 On Wednesday of last ... to use Redox Signaling molecules, became available for purchase in ... , "The way that RENU 28 works is, if you ... down of the rate of cellular renewal within your body. ... increasing of that rate of cellular renewal. What RENU 28 ...
(Date:8/20/2014)... licensed to biotechnology firms has revealed early bottlenecks ... roadblocks, the researchers suggest that better communication of ... lead to faster commercialization down the road. , ... in university laboratories and licensed to biotechnology firms. ... have a high failure rate. But a new ...
Breaking Biology Technology:Pursuit's Peter Robinson Publishes "Grading Pharma's Use of New Commercial Sales Models" 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 3RENU 28 Skin Care Now Available in Australia and New Zealand 2Early bottlenecks in developing biopharmaceutical products delay commercialization 2Early bottlenecks in developing biopharmaceutical products delay commercialization 3
... Two physicists from The University of Manchester who discovered ... for their work. , Professor Andre Geim FRS and ... Nanotechnology have been awarded the prestigious Europhysics Prize for ... reveal its remarkable electronic properties. , Graphene is a ...
... Inc.,(Nasdaq: MEDX ) announced today that it is ... at 9:10 a.m. Eastern Time on,Thursday, September 4, 2008. ... in the Investor Relations section of the Medarex website ... will be available,following the event., About Medarex, ...
... presentations included Resverlogix data, TSX Exchange Symbol: ... Corp.,("Resverlogix" or the "Company") (TSX:RVX) is pleased to ... pertaining to its lead compound,RVX-208, at the European ... titled "RVX-208 a novel small molecule that increases,apolipoprotein ...
Cached Biology Technology:Graphene pioneers follow in Nobel footsteps 2Medarex to Present at the Thomas Weisel Partners Healthcare Conference 2ApoA-I Data Presented at European Society of Cardiology Congress 2
Goat polyclonal to Ephrin B2 ( Abpromise for all tested applications). entrezGeneID: 1948 SwissProtID: P52799...
Pronase Reagent...
Mouse monoclonal [7E10] to C Peptide ( Abpromise for all tested applications). entrezGeneID: 3630 SwissProtID: P01308...
p38 MAP Kinase gamma Antibody Shipping Temperature: HOT Storage Temperature: -20C...
Biology Products: