Navigation Links
Posttraumatic stress disorder treatment: Genetic predictor of response to exposure therapy
Date:6/11/2013

Philadelphia, PA, June 11, 2013 There is growing evidence that a gene variant that reduces the plasticity of the nervous system also modulates responses to treatments for mood and anxiety disorders. In this case, patients with posttraumatic stress disorder, or PTSD, with a less functional variant of the gene coding for brain-derived neurotrophic factor (BDNF), responded less well to exposure therapy.

This gene has been implicated previously in treatment response. Basic science studies have convincingly shown that BDNF levels are an important modifier of the therapeutic effects of antidepressants in animal models. Other researchers have made similar findings in a small group of depressed patients treated with the rapid-acting antidepressant ketamine. Low BDNF plasma levels also have been linked to poorer effects of cognitive rehabilitation in schizophrenia. BDNF infused directly into the infralimbic prefrontal cortex in rats was found to extinguish conditioned fear, and BDNF levels were found to modulate the amount of fear extinction.

"Findings are accumulating to suggest that BDNF is an important modifier of the responses to a number of clinical interventions, presumably because BDNF is such an important regulator of neuroplasticity, i.e., the ability of the brain to adapt," said Dr. John Krystal, Editor of Biological Psychiatry.

In this study, researchers from Australia and Puerto Rico teamed up to investigate the influence of the BDNF Val66Met genotype on response to exposure therapy in patients with PTSD. They recruited 55 patients, all of whom participated in an 8-week exposure-based cognitive behavior therapy program.

Exposure therapy is currently the most effective treatment for PTSD, although it does not work for everyone. This type of therapy is delivered over multiple one-on-one sessions with a trained therapist, with a goal of reducing patients' fear and anxiety.

They found that patients with the Me
'/>"/>

Contact: Rhiannon Bugno
Biol.Psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

Page: 1 2

Related biology news :

1. Stress hormones: Good or bad for posttraumatic stress disorder risk?
2. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
3. Some corals like it hot: Heat stress may help coral reefs survive climate change
4. Lizard moms may prepare their babies for a stressful world
5. Researcher awarded $1 million for stress-associated disease and aging research
6. Low-income moms under stress may overfeed infants
7. Study offers new insights into the effects of stress on pregnancy
8. NUS-led research team discovers how bacteria sense salt stress
9. LSUHSC research finds treating stress prevented new MS brain lesions
10. Red hair is a sign of oxidative stress in wild boars, but gray is a-ok
11. Bend or stretch? How stressful is hyperflexion of horses necks?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/12/2015)... 12, 2015 Beta Systems ... and access management (IAM) solution for a fixed ... Beta System,s new IAM package, customers benefit from ... from multiple IAM implementations across different industries. The ... well as any necessary services and consulting. It ...
(Date:3/10/2015)... Colo. , March 10, 2015 ... Flight "Personalized Medicine in Human Space ... and Thomas J. Goodwin , Ph.D. was recently ... of the past two years. Specifically, "Personalized ... most downloaded scientific papers published in 2013 and 2014 ...
(Date:3/3/2015)... FOREST, Calif. , March 3, 2015 ... the leading provider of advanced cryogenic logistics ... markets including immunotherapies, stem cells, cell lines, ... and reproductive medicine, today announced the expansion ... Cancer Research Centers, ("Fred Hutch") Clinical ...
Breaking Biology News(10 mins):Beta Systems Fast Forward IAM Available Now: a Standardized IAM Package at a Fixed Price 2"Personalized Medicine in Human Space Flight" Listed Among Most Influential Papers of 2013 and 2014 2Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 2Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 3
... is emerging for how important it is for pregnant women ... every day seem to have children who are less likely ... study from the Sahlgrenska Academy at the University of ... with Linkping University, which is conducting a population study called ...
... awarded $6.27 million to develop an interactive software system ... home. The funding, which covers a two-year period, includes ... Projects Agency-Energy (ARPA-E), About $1.28 million in matching grants ... Energy Commission. The Stanford team will focus on ...
... Origin of Species 150 years ago, he deliberately avoided the ... mention of the ,Creator, in the last paragraph of the ... commit on the matter. An international team, led by Juli ... idea and shows that the British naturalist did explain in ...
Cached Biology News:Vegetables can protect unborn child against diabetes 2Stanford researchers awarded $6.27 million to study energy efficiency and human behavior 2Charles Darwin really did have advanced ideas about the origin of life 2
(Date:4/1/2015)... NJ (PRWEB) April 01, 2015 Earlier ... BioNJ, a vibrant life sciences industry association that represents ... 400 members. , Jonathan Parker, AJO’s Vice President ... Gala Dinner in February, an event that attracted over ... highlights, Don Wright, a 73 year old cancer survivor ...
(Date:3/31/2015)... 2015 CytoSorbents Corporation (NASDAQ CM: CTSO), ... to treat critically-ill and cardiac surgery patients in ... reports financial results for the fiscal year ending ... product revenues were a record $3.1M, an increase ... revenues of $0.8M Highlights for the Year Ending ...
(Date:3/31/2015)... Richmond, KY (PRWEB) March 31, 2015 ... top 50 schools for online bachelor’s of criminal ... committed to connecting people to inspiring ideas and ... in an e-mail to the University. We are ... Kentucky University.” , This is the site’s ...
(Date:3/31/2015)... , March 31, 2015  Sonoa Health, a health ... , has developed a world-first consumer health portal, Health&, ... prescriptions, wearable devices and more. Today, the ... as its CEO, who brings to the table more ... which has included working closely with the biggest names ...
Breaking Biology Technology:HR Consulting Firm, A.J. O'Connor Associates Joins BioNJ – The Vibrant 400 Member Strong Life Sciences Industry Association - and Attends its Annual Dinner 2CytoSorbents Reports Record 2014 Revenue 2CytoSorbents Reports Record 2014 Revenue 3CytoSorbents Reports Record 2014 Revenue 4CytoSorbents Reports Record 2014 Revenue 5CytoSorbents Reports Record 2014 Revenue 6CytoSorbents Reports Record 2014 Revenue 7CytoSorbents Reports Record 2014 Revenue 8CytoSorbents Reports Record 2014 Revenue 9CytoSorbents Reports Record 2014 Revenue 10CytoSorbents Reports Record 2014 Revenue 11EKU Ranked in Top 50 Among Online Criminal Justice Degrees 2Investment Banker Appointed CEO of Australian Health Tech Start-Up 2Investment Banker Appointed CEO of Australian Health Tech Start-Up 3
... Technology, Inc. announced today that Jim Bullock has been ... company.  Before joining Zyga Technology, Jim was President and ... Boston Scientific.  Prior to Atritech, Jim was President and ... St. Jude Medical.  (Logo: http://photos.prnewswire.com/prnh/20110118/CG30384LOGO ...
... BEIJING, January 16, 2012 Elsevier, ... information products and services, announced today that its ... management, NursingChina , is now available online. ... online reference product available in China, featuring skills ...
... in a wide variety of applications from food ... applications. Thermal analysis is routinely used to analyze ... to use nanostructured materials has made bulk techniques ... force microscope-based technique called nanoscale thermal analysis (nanoTA) ...
Cached Biology Technology:Zyga Technology, Inc. Announces the Appointment of Jim Bullock as President and CEO 2Elsevier Launches Bilingual International Nursing Skill Training and Management Platform: NursingChina.com 2Elsevier Launches Bilingual International Nursing Skill Training and Management Platform: NursingChina.com 3Magnetic actuation enables nanoscale thermal analysis 2
... Hypothetical protein FLJ20644, likely ortholog of ... Protein Accession #: NP_060387.1 gi ... Definition: chromosome 14 open reading frame ... gene g4-1 [Homo sapiens] Locus ...
1/4" to 1/8" Adapter for Reflectance Probe Holder...
ACAT-1 (H-125)...
Mouse monoclonal [B314.1 (MAC 387)] to Macrophage L1 protein Calprotectin (rating: ****) ( Abpromise for all tested applications)....
Biology Products: