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Possible treatment target found for main cause of severe liver disease in kids
Date:11/8/2011

ne, which points to how immune system dendritic cells trigger the initial immune response in a mouse model of biliary atresia.

The September study reported that dendritic cells which process and transmit signals from the surfaces of tissues to recruit other immune system components activated natural killer cells in the immune system. This activation set off a cascade of hyperactive immune response in the newborn mice, worsening the disease.

Researchers were able to disable the process be depleting or blocking the signaling activity of plasmacytoid dendritic cells and Interleukin 15. This prevented injury of the bile ducts and shut down the disease process. Bezerra cautioned that more research is needed before determining whether blocking this process may have therapeutic benefit in humans.
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Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

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